Podcast
Questions and Answers
Which ligand is expressed on the surface of effector CD8+ cells and TH1 cells to exert cytotoxic effects?
Which ligand is expressed on the surface of effector CD8+ cells and TH1 cells to exert cytotoxic effects?
- CD80 Ligand
- CD28 Ligand
- Fas Ligand (correct)
- CD40 Ligand
What is the role of CD40 Ligand in T cell activation?
What is the role of CD40 Ligand in T cell activation?
- Promote differentiation into TH2 cells
- Activate B cells and innate immune cells (correct)
- Exert cytotoxic effect
- Induce proliferation of T cells
Which ligand binds Fas on the surface of infected or stressed cells in the periphery?
Which ligand binds Fas on the surface of infected or stressed cells in the periphery?
- TNF Ligand
- Fas Ligand (correct)
- CD40 Ligand
- CD28 Ligand
What provides Signal 3 for CD8+ T cell activation into Cytotoxic T lymphocytes (CTL)?
What provides Signal 3 for CD8+ T cell activation into Cytotoxic T lymphocytes (CTL)?
In T cell activation, what role does the interaction between CD28 and B7 play?
In T cell activation, what role does the interaction between CD28 and B7 play?
Which type of T cells don't express CD40 Ligand ?
Which type of T cells don't express CD40 Ligand ?
What is a key part of licensing for both CD4+ and CD8+ T cells?
What is a key part of licensing for both CD4+ and CD8+ T cells?
Which process occurs in a simultaneous fashion during CD8+ T cell activation?
Which process occurs in a simultaneous fashion during CD8+ T cell activation?
What leads to increased expression of costimulatory molecules like CD80 and CD86 on APCs?
What leads to increased expression of costimulatory molecules like CD80 and CD86 on APCs?
Which molecule helps in directing the immune response upon CTL activation?
Which molecule helps in directing the immune response upon CTL activation?
What is the first step in CTL-mediated killing of infected cells?
What is the first step in CTL-mediated killing of infected cells?
Which molecule is responsible for inducing apoptosis in infected cells during Fas-FasL mediated killing?
Which molecule is responsible for inducing apoptosis in infected cells during Fas-FasL mediated killing?
What triggers the release of granules by CTLs during granule-mediated killing?
What triggers the release of granules by CTLs during granule-mediated killing?
Which process involves reorganizing the cytoskeleton and cytoplasmic contents by CTLs?
Which process involves reorganizing the cytoskeleton and cytoplasmic contents by CTLs?
What is a critical action that APCs must take to present antigen to both CD4+ and CD8+ T cells?
What is a critical action that APCs must take to present antigen to both CD4+ and CD8+ T cells?
What is an essential requirement for CD8+ T cell activation to occur?
What is an essential requirement for CD8+ T cell activation to occur?
What is the main function of Perforin in CTLs?
What is the main function of Perforin in CTLs?
Which proteins are found in the granules of CTLs?
Which proteins are found in the granules of CTLs?
What is the consequence of Granzyme B entering the cytoplasm of the target cell?
What is the consequence of Granzyme B entering the cytoplasm of the target cell?
Which pathway converges on caspase-3 activation, ultimately leading to apoptosis?
Which pathway converges on caspase-3 activation, ultimately leading to apoptosis?
What is the function of CTLs in recognizing infected or tumor cells?
What is the function of CTLs in recognizing infected or tumor cells?
How do CD8+ T cells induce apoptosis in infected target cells?
How do CD8+ T cells induce apoptosis in infected target cells?
What is a classic sign of apoptosis observed in the text after 40 minutes of CTL interaction with a target cell?
What is a classic sign of apoptosis observed in the text after 40 minutes of CTL interaction with a target cell?
What is the role of Granules in CTLs during effector responses?
What is the role of Granules in CTLs during effector responses?
What happens when TCR on CTL binds pMHC?
What happens when TCR on CTL binds pMHC?
How are Fas Ligand and CD40 Ligand classified based on their location in the cell?
How are Fas Ligand and CD40 Ligand classified based on their location in the cell?
Which cells express Fas Ligand on their surface to exert cytotoxic effects?
Which cells express Fas Ligand on their surface to exert cytotoxic effects?
Which ligand binds to CD40 on B cells and innate immune cells for activation?
Which ligand binds to CD40 on B cells and innate immune cells for activation?
What type of cells require more co-stimulation through B7/CD28 interaction?
What type of cells require more co-stimulation through B7/CD28 interaction?
How do CD8+ T cells recognize and kill infected/tumour cells?
How do CD8+ T cells recognize and kill infected/tumour cells?
What is the main source of Signal 3 for CD8+ T cell activation into Cytotoxic T lymphocytes (CTL)?
What is the main source of Signal 3 for CD8+ T cell activation into Cytotoxic T lymphocytes (CTL)?
In most cases, how are CD8+ cells activated to become cytotoxic effector cells?
In most cases, how are CD8+ cells activated to become cytotoxic effector cells?
What is a rare but possible way for CD8+ cells to be activated without the help of CD4 effector T cells?
What is a rare but possible way for CD8+ cells to be activated without the help of CD4 effector T cells?
How do majority of CD8+ cells obtain the necessary activation signals for proliferation and differentiation into CTL formation?
How do majority of CD8+ cells obtain the necessary activation signals for proliferation and differentiation into CTL formation?
Flashcards are hidden until you start studying
