18 Questions
What factor permits cross-linking of fibrin into polymers to stabilize the fibrin clot?
Platelets
Which natural anticoagulant inhibits factors IIa, Xa, and other coagulation factors?
Antithrombin III
What is the role of Ca ions in the coagulation cascade?
Activate most phases except the first 2 steps in the intrinsic pathway
Which autocrine-paracrine mediator inhibits platelet activation?
Nitric oxide
What is the fate of a blood clot once formed?
Stabilizes and is prevented from further extension
Which factor prevents clot extension once formed by inhibiting the extrinsic Tenase complex?
Tissue-Factor Pathway Inhibitor (TFPI)
What is the role of platelets in the hemostatic mechanism?
Equip themselves with repulsion forces to prevent sticking to the endothelium
In the hemostatic mechanism, what is the role of vitamin K?
Promote clot formation by activating clotting factors
How does calcium contribute to the hemostatic mechanism?
Facilitates the conversion of plasminogen into plasmin to digest fibrin clots
What is the fate of a blood clot?
Undergoes digestion and lysis by plasmin
Which factor prevents activation of clotting factors by not allowing them to come in contact with tissue factor (TF)?
Optimal blood flow speed
What is the function of natural anticoagulants like anti-thrombin lll and heparin in preventing coagulation?
Antagonize coagulation
What is the role of anticoagulant agents in the hemostatic mechanism?
Inhibit coagulation to prevent clot formation
Which of the following is an indirect inhibitor of thrombin formation in the hemostatic mechanism?
Activating anti-thrombin III
How does tissue plasminogen activator (t-PA) contribute to hemostasis?
Induces fibrinolysis by activating plasminogen
What is the fate of a blood clot in the hemostatic mechanism?
Undergoes lysis or forms connective tissue
How do anticoagulant agents contribute to preventing emboli from dislodging?
Inhibit coagulation steps like thrombin formation
What is the role of vitamin K in the hemostatic mechanism?
Blocks coagulative profile of Vit K-dependent factors
Explore the various factors that work together to maintain blood in a fluid, un-clotted state in healthy blood vessels. Learn how these factors prevent unnecessary clot formation and thrombosis, which can lead to blockages in blood supply.
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