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Factors preventing blood clotting in healthy vessels

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Factors preventing blood clotting in healthy vessels

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Questions and Answers

What factor permits cross-linking of fibrin into polymers to stabilize the fibrin clot?

Antithrombin III

Vitamin K

Protein C

Platelets (correct)

Which natural anticoagulant inhibits factors IIa, Xa, and other coagulation factors?

Protein S

Heparin

Antithrombin III (correct)

Protein C

What is the role of Ca ions in the coagulation cascade?

Promote vasodilation

Inhibit platelet activation

Inhibit anticoagulants

Activate most phases except the first 2 steps in the intrinsic pathway (correct)

Which autocrine-paracrine mediator inhibits platelet activation?

Nitric oxide Signup and view all the answers

What is the fate of a blood clot once formed?

Stabilizes and is prevented from further extension Signup and view all the answers

Which factor prevents clot extension once formed by inhibiting the extrinsic Tenase complex?

Tissue-Factor Pathway Inhibitor (TFPI) Signup and view all the answers

What is the role of platelets in the hemostatic mechanism?

Equip themselves with repulsion forces to prevent sticking to the endothelium Signup and view all the answers

In the hemostatic mechanism, what is the role of vitamin K?

Promote clot formation by activating clotting factors Signup and view all the answers

How does calcium contribute to the hemostatic mechanism?

Facilitates the conversion of plasminogen into plasmin to digest fibrin clots Signup and view all the answers

What is the fate of a blood clot?

Undergoes digestion and lysis by plasmin Signup and view all the answers

Which factor prevents activation of clotting factors by not allowing them to come in contact with tissue factor (TF)?

Optimal blood flow speed Signup and view all the answers

What is the function of natural anticoagulants like anti-thrombin lll and heparin in preventing coagulation?

Antagonize coagulation Signup and view all the answers

What is the role of anticoagulant agents in the hemostatic mechanism?

Inhibit coagulation to prevent clot formation Signup and view all the answers

Which of the following is an indirect inhibitor of thrombin formation in the hemostatic mechanism?

Activating anti-thrombin III Signup and view all the answers

How does tissue plasminogen activator (t-PA) contribute to hemostasis?

Induces fibrinolysis by activating plasminogen Signup and view all the answers

What is the fate of a blood clot in the hemostatic mechanism?

Undergoes lysis or forms connective tissue Signup and view all the answers

How do anticoagulant agents contribute to preventing emboli from dislodging?

Inhibit coagulation steps like thrombin formation Signup and view all the answers

What is the role of vitamin K in the hemostatic mechanism?

Blocks coagulative profile of Vit K-dependent factors Signup and view all the answers