8 Questions
Which physiological factor can modify the action of drugs in newborns?
Gastric acidity
What factor is used to calculate the body surface area for prescribing drug dosage?
Height and weight
Why is the drug dosage decreased for newborns?
Inadequate gastric acidity
Which physiological factor is particularly relevant for prescribing drug dosage in children?
Body surface area
What deficiency in newborns can affect the action of certain drugs like Chloramphenicol?
Liver microsomal enzymes (glucuronyl transferase)
Which physiological change in the geriatric age group requires special consideration for drug therapy?
Reduced renal function
What adverse effect may antihistaminics cause in children?
Hyperactivity
What potential effect may corticosteroids have on growth and development in children?
Retardation
Study Notes
Physiological Factors Affecting Drug Action
- Immaturity of hepatic enzyme system: a physiological factor that can modify the action of drugs in newborns
- Body surface area: the factor used to calculate drug dosage for prescribing
- Reduced hepatic metabolism: the reason for decreasing drug dosage in newborns
Newborns and Drug Action
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency: a deficiency in newborns that can affect the action of certain drugs like Chloramphenicol
Geriatric Age Group and Drug Therapy
- Age-related decline in renal function: a physiological change that requires special consideration for drug therapy in the geriatric age group
Adverse Effects of Drugs in Children
- Antihistaminics: may cause antisocial behavior in children
- Corticosteroids: may have a potential effect on growth and development in children
Test your knowledge of factors that modify the action of drugs with this quiz. Explore physiological, pathological, genetic, and environmental factors, as well as drug interactions. Topics include age, sex, pregnancy, plasma protein binding, body weight, lactation, food, and allergies. Perfect for students of pharmacology and related fields.
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