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Questions and Answers
What is drug absorption?
What is drug absorption?
The process of the movement of a drug from the site of administration into the extracellular compartment of the body.
What is the most common mechanism of absorption?
What is the most common mechanism of absorption?
Passive non-ionic diffusion.
What factors influence drug absorption?
What factors influence drug absorption?
Molecular size, shape, degree of ionization, and lipid solubility.
What is disintegration?
What is disintegration?
Which types of SDFs are exempt from disintegration requirements according to USP guidelines?
Which types of SDFs are exempt from disintegration requirements according to USP guidelines?
What is dissolution?
What is dissolution?
How is solubility determined in pharmaceutical development?
How is solubility determined in pharmaceutical development?
What is the relationship between dissolution and absorption?
What is the relationship between dissolution and absorption?
What is the purpose of the Disintegration Apparatus 5?
What is the purpose of the Disintegration Apparatus 5?
What are the factors affecting oral drug absorption?
What are the factors affecting oral drug absorption?
What are the official guidelines for disintegration of most SDFs according to USP?
What are the official guidelines for disintegration of most SDFs according to USP?
Where can the USP disintegration diagram be found?
Where can the USP disintegration diagram be found?
What are the factors affecting oral drug absorption?
What are the factors affecting oral drug absorption?
What are the dosage forms discussed?
What are the dosage forms discussed?
What is drug absorption?
What is drug absorption?
What is the difference between controlled-release and immediate release products?
What is the difference between controlled-release and immediate release products?
How do the plasma concentration time-curves differ between controlled-release and immediate release products?
How do the plasma concentration time-curves differ between controlled-release and immediate release products?
What are drug bioavailability and bioequivalence?
What are drug bioavailability and bioequivalence?
How do drug bioavailability and bioequivalence differ?
How do drug bioavailability and bioequivalence differ?
What are the three indices of bioavailability?
What are the three indices of bioavailability?
What is the Biopharmaceutics Classification System (BCS)?
What is the Biopharmaceutics Classification System (BCS)?
What are the factors considered in the Biopharmaceutics Classification System (BCS)?
What are the factors considered in the Biopharmaceutics Classification System (BCS)?
What is the purpose of dissolution testing?
What is the purpose of dissolution testing?
What is the rate-limiting step for low water soluble (hydrophobic) drugs?
What is the rate-limiting step for low water soluble (hydrophobic) drugs?
Drug absorption is the process of the movement of drug from the site of administration into the extracellular compartment of the body. GI tract is an important factor in oral ______.
Drug absorption is the process of the movement of drug from the site of administration into the extracellular compartment of the body. GI tract is an important factor in oral ______.
Passive non-ionic diffusion is the most common mechanism of ______.
Passive non-ionic diffusion is the most common mechanism of ______.
Absorption is influenced by 4 factors 1. ______ 2. ______ 3. ______ 4. lipid solubility.
Absorption is influenced by 4 factors 1. ______ 2. ______ 3. ______ 4. lipid solubility.
Disintegration is required for oral solid dosage forms (SDFs) to allow drug ______.
Disintegration is required for oral solid dosage forms (SDFs) to allow drug ______.
Permeability is an ______ measurement of absorption.
Permeability is an ______ measurement of absorption.
Disintegration guidelines apply to most SDFs with the exception of ______, chewable tablets, and modified release DFs.
Disintegration guidelines apply to most SDFs with the exception of ______, chewable tablets, and modified release DFs.
Rate-Limiting Steps in Drug Absorption - Slowest step = the ______ step
Rate-Limiting Steps in Drug Absorption - Slowest step = the ______ step
Dissolution is the process where the drug ______ in a solvent.
Dissolution is the process where the drug ______ in a solvent.
Generally, tablet ______ is the fastest step.
Generally, tablet ______ is the fastest step.
For pharmaceutical development, ______ is determined by dissolving a known quantity of a drug in 250mL buffer (pH 1.0-8.0).
For pharmaceutical development, ______ is determined by dissolving a known quantity of a drug in 250mL buffer (pH 1.0-8.0).
Dissolution is often the ______ step for low water soluble (hydrophobic) drugs.
Dissolution is often the ______ step for low water soluble (hydrophobic) drugs.
Rate of dissolution is often directly related to the rate of ______.
Rate of dissolution is often directly related to the rate of ______.
Permeability is often the ______ step for high water soluble (hydrophilic) drugs.
Permeability is often the ______ step for high water soluble (hydrophilic) drugs.
The factors affecting oral drug absorption include ______, disintegration, dissolution and solubility.
The factors affecting oral drug absorption include ______, disintegration, dissolution and solubility.
Solutions are already ______ so dissolution is not a rate limiting step
Solutions are already ______ so dissolution is not a rate limiting step
The factors affecting oral drug absorption also include disintegration, ______ and solubility.
The factors affecting oral drug absorption also include disintegration, ______ and solubility.
Drug particles are ______ in a vehicle
Drug particles are ______ in a vehicle
The official guidelines for disintegration of most SDFs according to USP can be found in ______.
The official guidelines for disintegration of most SDFs according to USP can be found in ______.
Efficient dosage form distinguished by a shell that holds the drug formulation. Shell must release the drug particles before absorption can take place. Can be formulated as controlled-release to alter absorption kinetics. Must first break into granules/large pieces and then into drug particles. Can be formulated as ______ to alter absorption kinetics.
Efficient dosage form distinguished by a shell that holds the drug formulation. Shell must release the drug particles before absorption can take place. Can be formulated as controlled-release to alter absorption kinetics. Must first break into granules/large pieces and then into drug particles. Can be formulated as ______ to alter absorption kinetics.
The Disintegration Apparatus 5 is used to test the ______ of oral solid dosage forms.
The Disintegration Apparatus 5 is used to test the ______ of oral solid dosage forms.
For oral products, bioavailability depends on the drugs ______ and absorption
For oral products, bioavailability depends on the drugs ______ and absorption
Can be altered by the drugs stability in gastric fluids, formulation components, and first-pass effect (hepatic metabolism).
Can be altered by the drugs stability in gastric fluids, formulation components, and first-pass effect (hepatic metabolism).
Used to describe the bioavailability of same drug in two different formulations. Important for comparing generic products with the name-brand product. Testing typically involves in vivo human PK studies to evaluate the rate and extent of ______.
Used to describe the bioavailability of same drug in two different formulations. Important for comparing generic products with the name-brand product. Testing typically involves in vivo human PK studies to evaluate the rate and extent of ______.
Biopharmaceutics Classification System (BCS) – ______ – Permeability
Biopharmaceutics Classification System (BCS) – ______ – Permeability
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