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Factors Affecting Vaccine Protection

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Questions and Answers

Which factor is NOT significant in planning immunization programs?

Vaccine schedule

Prior antigen exposure

Vaccine price (correct)

Age of vaccination

What type of immune response is induced by live attenuated virus vaccines?

B cells, CD4 T cells, and CD8 T cells (correct)

Monoclonal antibody response

Only B cell response

Only CD4 T cell response

Which of the following diseases currently has effective vaccines developed?

Ebola

HIV-1

Foot and mouth disease (correct)

Hepatitis C

Which aspect of vaccine dose is established during early clinical development?

<p>Optimal safety and immunogenicity (A)</p> Signup and view all the answers

What is a primary advantage of live attenuated virus vaccines?

<p>They replicate and increase virus antigen in the body (C)</p> Signup and view all the answers

Flashcards

Factors affecting vaccine protection

The level of protection provided by vaccines can be influenced by various factors, including age, prior exposure to the virus, and the vaccination schedule.

Live attenuated vaccine

A live attenuated vaccine contains a weakened version of a virus that can still replicate in the body but doesn't cause disease.

Advantages of live attenuated vaccines

Live attenuated vaccines have several advantages over other types, including generating a broader immune response involving B cells, CD4 and CD8 T cells, and a continuous supply of viral antigen as the weakened virus replicates.

Diseases prevented by live attenuated vaccines

Live attenuated vaccines are effective against various diseases, including polio, rubella, and rabies.

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Limitations of live attenuated vaccines

Despite their success, live attenuated vaccines have not been developed against many other viruses, including HIV-1, hepatitis C, Ebola, and herpes simplex.

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Study Notes

Factors Affecting Vaccine Protection

Vaccine protection is influenced by genetics, environment, age, maternal antibodies, prior exposure to antigens, vaccine schedule, and dose.
Age at vaccination and schedule are crucial for immunization programs, although other factors aren't readily adjustable.
Vaccine dose is determined during early clinical trials based on safety and immunogenicity.

Live Attenuated Virus Vaccines

Live attenuated vaccines use a mutated, less harmful form of a virus.
These vaccines offer more advantages compared to other types.
Replication of the virus within the body provides increasing amounts of viral antigen.
A diverse immune response is stimulated, including B cells, CD4 T cells, and CD8 T cells.
Effective live attenuated vaccines exist for several viral diseases (polio, rubella, rabies, foot-and-mouth disease).
Development of effective vaccines for other viruses, including HIV-1, hepatitis C, Ebola, and herpes simplex viruses, remains challenging.

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Description

Explore the various factors that influence vaccine efficacy, including genetics, age, and vaccine schedules. This quiz also covers the concept of live attenuated vaccines and their role in stimulating the immune response. Test your knowledge on these critical aspects of immunization!