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Questions and Answers
Which factor is NOT significant in planning immunization programs?
Which factor is NOT significant in planning immunization programs?
- Vaccine schedule
- Prior antigen exposure
- Vaccine price (correct)
- Age of vaccination
What type of immune response is induced by live attenuated virus vaccines?
What type of immune response is induced by live attenuated virus vaccines?
- B cells, CD4 T cells, and CD8 T cells (correct)
- Monoclonal antibody response
- Only B cell response
- Only CD4 T cell response
Which of the following diseases currently has effective vaccines developed?
Which of the following diseases currently has effective vaccines developed?
- Ebola
- HIV-1
- Foot and mouth disease (correct)
- Hepatitis C
Which aspect of vaccine dose is established during early clinical development?
Which aspect of vaccine dose is established during early clinical development?
What is a primary advantage of live attenuated virus vaccines?
What is a primary advantage of live attenuated virus vaccines?
Flashcards
Factors affecting vaccine protection
Factors affecting vaccine protection
The level of protection provided by vaccines can be influenced by various factors, including age, prior exposure to the virus, and the vaccination schedule.
Live attenuated vaccine
Live attenuated vaccine
A live attenuated vaccine contains a weakened version of a virus that can still replicate in the body but doesn't cause disease.
Advantages of live attenuated vaccines
Advantages of live attenuated vaccines
Live attenuated vaccines have several advantages over other types, including generating a broader immune response involving B cells, CD4 and CD8 T cells, and a continuous supply of viral antigen as the weakened virus replicates.
Diseases prevented by live attenuated vaccines
Diseases prevented by live attenuated vaccines
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Limitations of live attenuated vaccines
Limitations of live attenuated vaccines
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Study Notes
Factors Affecting Vaccine Protection
- Vaccine protection is influenced by genetics, environment, age, maternal antibodies, prior exposure to antigens, vaccine schedule, and dose.
- Age at vaccination and schedule are crucial for immunization programs, although other factors aren't readily adjustable.
- Vaccine dose is determined during early clinical trials based on safety and immunogenicity.
Live Attenuated Virus Vaccines
- Live attenuated vaccines use a mutated, less harmful form of a virus.
- These vaccines offer more advantages compared to other types.
- Replication of the virus within the body provides increasing amounts of viral antigen.
- A diverse immune response is stimulated, including B cells, CD4 T cells, and CD8 T cells.
- Effective live attenuated vaccines exist for several viral diseases (polio, rubella, rabies, foot-and-mouth disease).
- Development of effective vaccines for other viruses, including HIV-1, hepatitis C, Ebola, and herpes simplex viruses, remains challenging.
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