Extracellular Matrix Quiz

A specialized extracellular matrix (ECM) layer separating epithelial tissue from connective tissue. It's composed of key proteins like laminin, type IV collagen, nidogen, and perlecan.

Acts as a selective filter for molecules and cells, allowing only specific substances to pass through. Also provides a scaffold for tissue regeneration.

A dynamic structure that surrounds cells in tissues, constantly adapting and changing to meet the needs of the cells.

ECM provides a supportive network for maintaining the organization of synapses during neuromuscular junction regeneration.

Major components of the ECM include proteins like collagen and elastin, and polysaccharides such as glycosaminoglycans (GAGs) and proteoglycans.

Collagen, a key protein in ECM, forms strong fibers that provide structural support and strength to tissues.

GAGs and proteoglycans, found in ECM, are highly hydrated molecules that attract and hold water, providing cushioning and lubrication to tissues.

Fibronectin, an ECM protein, promotes cell adhesion and migration, facilitating cell-to-cell and cell-to-ECM interactions.

Amino acids that stabilize the helix structure of collagen. They are found in collagen, a key protein in the extracellular matrix.

A type of collagen that forms organized fibers, providing strength and structure to tissues. It is found in bones, skin, and tendons.

A type of collagen that creates a network-like structure, providing support and flexibility. It is found in the basal lamina, a key layer of the ECM.

Complex sugars that are part of the ECM. They attract and hold water, providing cushioning and lubrication.

A specialized type of collagen that helps stabilize another type of collagen in cartilage. It demonstrates how different collagen types can work together.

Proteins that bind cells to the ECM. Integrins are a key type of adhesion protein, aiding cell-ECM interaction.

A specific type of adhesion protein that is a transmembrane receptor, facilitating connections between the ECM and intracellular cytoskeleton.

The jelly-like substance that fills spaces between cells, providing hydration and resistance to compression.

A type of structural protein that forms a mesh-like network, providing strength and flexibility to the ECM.

Highly flexible fibrous protein found in the ECM, providing elasticity and resilience.

Large, complex molecules composed of a protein core attached to long chains of sugar molecules called glycosaminoglycans (GAGs), providing hydration and support within the ECM.

Provides structural support and tensile strength to tissues, like ligaments and tendons. Think of it as the 'steel rods' of your body.

A complex network of molecules outside cells, providing structural support, regulating cell behavior, and acting as a communication hub.

A type of glycosaminoglycan (GAG) found in the ECM. It forms elastic networks, providing cushioning and facilitating cell migration.

Fibrous protein that gives tissues like skin and blood vessels their elasticity, allowing them to stretch and recoil.

The ability of a material to return to its original shape after being deformed. Important for tissues like skin and arteries.

Amino acid that makes up a significant portion of collagen molecules. Its small size allows for tight packing of collagen fibers.

A protein present in the ECM that helps cells attach and migrate. It plays a role in tissue repair and development.

A triple helix structure formed by three polypeptide alpha chains. Provides strength and tensile strength to tissues.

A type of collagen that interacts with other collagens to form larger structures, contributing to the strength and flexibility of tissues.

A large, complex molecule found in cartilage, which resists compression due to its highly hydrated structure. It consists of a core protein with numerous attached glycosaminoglycans (GAGs).

Simple, non-sulfated glycosaminoglycan (GAG) involved in tissue repair. It attracts water and creates a 'space' for cell migration and healing.

A proteoglycan that regulates the assembly of collagen fibrils. It acts as a 'guide' for collagen fibers, ensuring proper alignment and strength.

Sulfated glycosaminoglycans (GAGs) found in cartilage, they contribute to the tissue's resilience and ability to withstand stress.

Proteoglycans that are embedded in cell membranes, they play a role in cell signaling and adhesion.

Strongly hydrated gel-like structures that resist compression. They consist of a core protein with numerous attached glycosaminoglycans (GAGs).