Extent of Sexually Transmitted Diseases

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Questions and Answers

Which of the following medications can be used to treat chlamydial infection?

  • Tinidazole 500 mg orally twice daily for 5 days
  • Erythromycin 500 mg orally four times a day (correct)
  • Cefixime 400 mg orally single dose (correct)
  • Metronidazole 500 mg orally three times a day

Quinolones are safe to use in pregnancy.

False (B)

What type of discharge is typically associated with trichomoniasis?

greenish frothy discharge

Partner management requires treating the current partner if there is no __________ after initial treatment.

<p>improvement</p> Signup and view all the answers

Which treatment is recommended for candidiasis during the first trimester of pregnancy?

<p>Local Clotrimazole treatment (D)</p> Signup and view all the answers

Match the types of vaginal discharge with their corresponding cause:

<p>Trichomoniasis = Greenish frothy discharge Candidiasis = Curdy white discharge Bacterial vaginosis = Adherent discharge Mixed infections = Atypical discharge</p> Signup and view all the answers

Bimanual pelvic examination is not necessary for assessing pelvic inflammatory disease.

<p>False (B)</p> Signup and view all the answers

What is the follow-up period after chlamydial infection treatment?

<p>7 days</p> Signup and view all the answers

What is the recommended treatment for male urethral discharge?

<p>Tab.Cefixime 400 mg orally, single dose + Tab Azithromycin 1 gram orally, single dose (B)</p> Signup and view all the answers

Syphilis testing is mandatory for all patients diagnosed with male urethral discharge.

<p>False (B)</p> Signup and view all the answers

What condition should be treated if symptoms of urethral discharge persist after initial treatment?

<p>T.vaginalis</p> Signup and view all the answers

In pregnant patients, it is recommended to use __________ to cover gonococcal infections.

<p>cephalosporins</p> Signup and view all the answers

Match the following syndromes with their descriptions:

<p>Male urethritis = Inflammation of the male urethra Salpingitis = Inflammation of the fallopian tubes Proctitis = Inflammation of the rectum Acquired Immuno Deficiency Syndrome (AIDS) = A serious disease affecting the immune system</p> Signup and view all the answers

What is one of the common syndromes associated with STDs in women?

<p>Vaginitis (A)</p> Signup and view all the answers

Syndromic management is more cost-effective than lab-based diagnosis.

<p>True (A)</p> Signup and view all the answers

What should be provided to partners of patients diagnosed with urethral discharge?

<p>Condoms</p> Signup and view all the answers

What should be administered to pregnant women with a positive RPR?

<p>Consider syphilis unless treated (A)</p> Signup and view all the answers

Pregnant women with a penicillin allergy should receive penicillin as treatment.

<p>False (B)</p> Signup and view all the answers

What treatment should be given to neonates following delivery if the mother had syphilis?

<p>The neonate should be treated according to guidelines.</p> Signup and view all the answers

Pregnant women with herpetic lesions at the onset of labor should be delivered by __________.

<p>cesarean section</p> Signup and view all the answers

In the case of a complicated gonococcal infection, what will Gram's stain examination show?

<p>Gram-negative intracellular diplococci (B)</p> Signup and view all the answers

Women without symptoms can deliver __________.

<p>vaginally</p> Signup and view all the answers

Match the treatment options with the corresponding conditions:

<p>Doxycycline = Contraindicated in pregnancy Erythromycin base = Safe in pregnancy Erythromycin estolate = Contraindicated due to hepatotoxicity Amoxicillin = Can be used in pregnancy</p> Signup and view all the answers

What is the recommended oral medication for pregnant women with a first episode of genital herpes?

<p>Acyclovir</p> Signup and view all the answers

What is the common treatment for Donovanosis?

<p>Azithromycin and doxycycline (D)</p> Signup and view all the answers

Genital herpes can be completely cured with antiviral medications.

<p>False (B)</p> Signup and view all the answers

Which virus is responsible for causing genital herpes?

<p>HSV-2</p> Signup and view all the answers

Human Papillomavirus (HPV) is linked to ________ cancer.

<p>cervical</p> Signup and view all the answers

Match the following conditions with their characteristics:

<p>Donovanosis = Painless papule that ruptures into granulomatous lesion Genital Herpes = Papular lesions that progress to blisters and ulcers HPV = Causes ano-genital warts Syphilis = Causes genital ulcers and is treated separately from gonococcal infection</p> Signup and view all the answers

Which of the following is primarily associated with genital herpes?

<p>Herpes simplex viruses (D)</p> Signup and view all the answers

Individuals from higher socio-economic groups have a lower risk of STD infections.

<p>True (A)</p> Signup and view all the answers

What is the primary cause of Donovanosis?

<p>Calymmatobacterium granulomatis</p> Signup and view all the answers

Higher STD rates are observed among individuals aged ______.

<p>20-24</p> Signup and view all the answers

Which factor does NOT contribute to an increase in STDs in developing countries?

<p>Increased marital stability (A)</p> Signup and view all the answers

Match the following STDs with their causative agents:

<p>Genital herpes = Herpes simplex viruses Vaginitis = Candida albicans Genital and anal warts = Human papillomaviruses AIDS = Human immunodeficiency virus (HIV)</p> Signup and view all the answers

Prostitution has no significant influence on the spread of STDs.

<p>False (B)</p> Signup and view all the answers

What demographic group experiences the highest morbidity rates for STDs?

<p>Men</p> Signup and view all the answers

Which of the following is a mild or moderate treatment for PID in women without a tubo-ovarian abscess?

<p>Tab.Cefixime and Tab.Metronidazole (A)</p> Signup and view all the answers

Doxycycline is considered safe for use in pregnant women.

<p>False (B)</p> Signup and view all the answers

What is the recommended dosage of Ibuprofen for managing pain in patients with PID?

<p>400 mg orally, three times per day for 3-5 days</p> Signup and view all the answers

The use of ________ should be advised during the treatment of PID to prevent gastritis.

<p>Ranitidine</p> Signup and view all the answers

Which of the following symptoms is NOT typically associated with lower abdominal pain in females?

<p>Nausea (D)</p> Signup and view all the answers

Match the following tests with their purpose:

<p>Wet smear examination = Diagnosis of PID Gram stain = Testing for gonorrhea Urine pregnancy test = Ruling out ectopic pregnancy Complete blood count = Assesses overall health and detects infections</p> Signup and view all the answers

What is the required protocol for treating male partners of women diagnosed with PID?

<p>Treat for urethral discharge and advise sexual abstinence.</p> Signup and view all the answers

Intrauterine devices should be left in place during PID treatment.

<p>False (B)</p> Signup and view all the answers

Flashcards

Donovanosis

A sexually transmitted infection (STI) characterized by painless sores that develop into granulomatous lesions.

Genital Herpes

An STI caused by HSV-2, presenting as blisters, sores, and recurrent outbreaks.

HPV (Human Papillomavirus)

Common STI causing genital warts and linked to cervical cancer.

Syndromic Approach to STDs

A method of diagnosing STIs based on similar symptoms instead of focusing on a specific organism.

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Genital Ulcers

Sores in the genital area, commonly caused by syphilis, chancroid, and genital herpes, treated separately from gonorrhea.

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HPV Treatment

Treatment for HPV generally focuses on large visible lesions, as subclinical infections often clear up on their own.

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STD Treatment

Treatment of STDs requires considering similar clinical manifestations or syndromes, then isolating the specific causative organism.

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Neonatal Conjunctivitis

Inflammation of the conjunctiva in newborns, often sexually transmitted.

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Donovanosis

A sexually transmitted infection caused by Calymmatobacterium granulomatis characterized by granulomas.

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Genital Herpes

Sexually transmitted infection caused by Herpes simplex viruses.

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Acute and Chronic Hepatitis

Liver inflammation, potentially caused by Hepatitis B virus.

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Genital and Anal Warts

Sexually transmitted infections caused by Human papillomaviruses (HPV).

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AIDS

Acquired Immunodeficiency Syndrome, the final stage of HIV infection.

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Genital Molluscum Contagiosum

Sexually transmitted skin infection characterized by small, flesh-colored bumps.

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Vaginitis

Inflammation of the vagina, potentially caused by Candida albicans or Trichomonas vaginalis.

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Highest STD Rates Age Group

20-24 year olds, followed by 25-29 and 15-19.

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STD Morbidity

Higher in men overall, more serious in women, particularly during fetal development and for newborns.

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Socioeconomic STD Risk

Individuals from lower socioeconomic groups are at a higher risk.

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Relationship Status and STD Risk

Single, divorced, and separated individuals have higher STD rates than married couples.

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STD Increase in Developing Countries

Increased population, young people, rural-urban migration, women's education lead to higher STD risks.

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STD Factors: Prostitution

Significant factor in STD transmission.

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STD Factors: Broken Homes

Promiscuity often linked to broken homes.

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STD Factors: Sexual Disharmony

Strained relationships in married couples lead to increased risk.

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STD Factors: Easy Money

Prostitution is common in poverty-stricken regions.

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STD Factors: Emotional Immaturity

A key factor in acquiring STDs.

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STD Factors: Urbanization/Industrialization

Increased risk due to long hours, isolation, social mobility, casual encounters.

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STD Factors: Social Disruption

Disasters, wars, and unrest increase vulnerability to STDs.

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STD Factors: International Travel

Contributes to the spread of resistant STDs.

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Syndromic Management of STDs

Diagnosing STIs based on similar symptoms, not specific organisms, for easier, more accessible diagnosis.

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Male Urethral Discharge

A symptom group used in syndromic management of STDs in males involving a discharge from the urethra.

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Treatment for Urethral Discharge

Single-dose Cefixime and Azithromycin are typical treatments under supervision, using syndromic management.

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Partner Management

Treating sexual partners of someone with an STD, even asymptomatic, to prevent further spread.

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Pregnancy and STDs

In pregnant individuals with STDs, cephalosporins are prioritized to treat gonococcal infections.

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Cost-Effectiveness

Syndromic management is more cost-effective than lab tests for STDs due to accessibility and quicker treatment.

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Accessibility

Syndromic management makes STD diagnosis and treatment easier and more available because of no need of lab facilities.

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Return Visit

Patients should return 7 days after treatment to ensure symptoms are resolved; or refer if necessary.

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Persistence of Symptoms

If symptoms don't clear after initial treatment, further investigation or different treatment may be required.

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Chlamydial Infection Treatment

Treat with erythromycin 500mg orally four times per day for 7 days or amoxicillin 500mg orally three times per day for 7 days

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Quinolone Contraindication

Quinolones should not be used during pregnancy

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Follow-up Schedule

Return visit scheduled 7 days after initial treatment

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Treatment Failure Assessment

Evaluate if the treatment was effective and identify reasons for symptom persistence

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Vaginal Discharge Confirmation

Clinician confirms the presence of vaginal discharge

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Menstrual History Importance

Assess menstrual history to rule out pregnancy during vaginal discharge assessment

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Vaginitis Discharge Types

Different types of vaginitis present with varying discharge colors (e.g. greenish frothy, curdy white, adherent)

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Cervicitis Symptoms

Cervicitis may include cervical erosions, ulcers, and mucopurulent discharge

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Pelvic Inflammatory Disease (PID) Assessment

Bimanual pelvic exam to screen for PID, a severe infection

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Secnidazole Dosage (Vaginitis)

2g orally, single dose, for vaginitis treatment

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Fluconazole Dosage (Candidiasis)

150mg orally, single dose, for yeast infection treatment

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Partner Management

Treating the sexual partner if symptoms are present or there is no improvement after initial treatment, advising on safe sex practices

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Pregnancy Treatment Modifications

Treatment strategies adjusted during pregnancy (e.g. using topical medications over oral ones for first trimester BV or Trich.)

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Lower abdominal pain in females

Pain in the lower abdomen, potentially a sign of an infection like Pelvic Inflammatory Disease (PID).

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Fever with lower abdominal pain

High body temperature along with pain in the lower abdomen, often a sign of infection.

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Vaginal discharge

Fluid or mucus that is released from the vagina; abnormal amount or appearance could be a symptom.

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Menstrual irregularities

Changes in the typical menstrual cycle; can be a symptom of a medical condition.

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Dysmenorrhea

Painful menstruation, often described as cramping.

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Dyspareunia

Painful sexual intercourse.

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Dysuria

Painful urination.

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Low backache

Pain in the lower back.

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IUD

Intrauterine device, a type of birth control.

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Per speculum examination

Examination of the vagina and cervix using a speculum.

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Per abdominal examination

Examination of the lower abdomen for tenderness or guarding.

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Pelvic examination

Examination of the pelvic organs for tenderness.

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Urine pregnancy test

A test to detect pregnancy hormones in urine.

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Wet smear examination

Microscopic examination of vaginal discharge.

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Syphilis in Pregnancy

Pregnant women with a positive RPR test are presumed to have syphilis until proven otherwise with documented treatment

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Syphilis Treatment (Pregnancy)

A second dose of penicillin 2.4 million units IM is administered one week after the initial dose for primary, secondary, or early latent syphilis in pregnant individuals.

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Penicillin Allergy (Pregnancy)

Erythromycin should be used for pregnant women with documented penicillin allergies who have syphilis.

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Neonate Treatment

Treat the newborn following delivery if the mother has syphilis.

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Genital Herpes & Pregnancy

Pregnant women with a history of genital herpes or current signs/symptoms should be evaluated for herpetic lesions.

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Vaginal Delivery (Herpes)

Women without active herpes lesions can deliver vaginally; women with active herpes lesions should deliver via Cesarean.

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Herpes Treatment (Pregnancy)

Acyclovir can be given orally to pregnant women with first-episode or severe recurrent genital herpes.

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Scrotal Swelling - History

Pain/swelling in the scrotum, possible urinary issues, systemic symptoms, and high-risk sexual history are clinical clues

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Scrotal Swelling - Examination

Physical examination includes scrotal swelling, redness/edema, epididymis/vas deferens tenderness, urethral discharge/ulcers/lymph nodes and the transillumination test for hydrocele.

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Scrotal Swelling - Lab Tests

Gram stain for urethral discharge (intracellular diplococci for gonorrhea) or neutrophil count in urine/discharge for non-gonococcal infections.

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Scrotal Swelling - Treatment (Simple)

Oral Cefixime and Doxycycline for 7 and 14 days respectively; refer to a specialized center for complicated cases.

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Scrotal Swelling - Treatment (Complicated)

Referrals to a higher center for complicated cases. Parenteral treatment and longer treatment durations are often needed for severe infections

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Partner Management (STIs)

Treating the sexual partner of someone with an STI, even if they show no symptoms.

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Pregnancy and Doxycycline

Doxycycline is contraindicated during pregnancy; use Erythromycin base/Amoxicillin instead.

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Study Notes

Extent of Sexually Transmitted Diseases (STDs)

  • Worldwide, the true incidence of STDs is unknown due to underreporting and secrecy
  • STDs are among the top 5 disease categories for adults seeking healthcare globally
  • Over 1 million new STIs are acquired daily.
  • An estimated 374 million new infections occur annually with one of four STIs
  • Data from 2020 show high prevalence of chlamydia (129 million), gonorrhoea (82 million), syphilis (7.1 million) and trichomoniasis (156 million)
  • Over 500 million people live with genital herpes infections
  • Over 300 million women have ongoing HPV infections
  • 296 million people live with chronic hepatitis B.
  • STIs can increase the risk of HIV acquisition by three-fold or more
  • STIs can cause stillbirth, neonatal death, low birth weight, prematurity, sepsis, pneumonia, neonatal conjunctivitis, and congenital deformities.
  • Over 900,000 pregnant women were infected with syphilis in 2012, leading to 350,000 adverse birth outcomes, including stillbirths.
  • HPV infection causes about 528,000 cases of cervical cancer each year and 266,000 cervical cancer deaths annually
  • STIs like gonorrhoea and chlamydia contribute significantly to pelvic inflammatory disease (PID) and female infertility.

STDs in India

  • Syphilis: 17,787 cases (6,088 males and 11,699 females) reported in 2020, with 40 deaths
  • Gonorrhoea: 27,582 cases (8,669 males and 18,903 females) reported in 2020, with 5 deaths.
  • Chancroid: Fair prevalence in India.
  • LGV: More prevalent in southern states (Tamil Nadu, Andhra Pradesh, Maharashtra, and Karnataka).
  • Donovanosis: Endemic in southern states (Tamil Nadu, Andhra Pradesh, Orissa, Karnataka, and Maharashtra) with higher prevalence in coastal regions.
  • Other STDs: Insufficient reporting data available.

Epidemiological Determinants

  • Agent factors: Over 20 pathogens transmitted through sexual contact. Table 2 outlines pathogens and diseases.
  • Host factors:
    • Age: Highest incidence in 20-24 year olds, followed by the 25-29 and 15-19 year old demographics.
    • Sex: Higher morbidity in men than women (e.g., PID).
    • Marital status: Higher frequency in single, divorced, and separated individuals.
    • Socio-economic status: Increased morbidity in lower socio-economic groups.
  • Demographic factors: Population explosion, young people, rural-urban migration, education opportunities for women, and delayed marriages.
  • Social factors: Prostitution, broken homes, sexual disharmony, emotional immaturity, urbanization, social disruptions, international travel, and changing behavioral patterns. Alcohol use.

Syndromic Approaches to STD

  • Many agents cause similar STDs. Table 3 illustrates syndromes and sequelae linked to STDs .
  • Diagnosing STDs is often based on clinical presentation, due to cost and availability issues, using flowcharts for diagnosis and treatment rather than just testing every time.

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