Exploring Dominant Negative Effects of Amino Acid Changes
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Questions and Answers

Which event can act as a dominant negative event?

  • The change of amino acid (correct)
  • The interference of a good protein
  • The degradation of a protein
  • The formation of a trimer

    • What happens when one allele of the gene encoding the type 1 collagen makes a protein that hinders proper helix formation?

  • The trimer containing that allele becomes functional
  • The trimer containing two good copies of the protein becomes non-functional
  • The trimer containing that allele becomes non-functional (correct)
  • The trimer containing two good copies of the protein becomes functional

    • What is the likelihood of a protein originating from an allele containing a stop codon?

  • It is likely to interfere with the good protein
  • It is likely to be degraded very fast (correct)
  • It is likely to hinder proper helix formation
  • It is likely to form a functional trimer

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