Protein Synthesis I,II
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Questions and Answers

Which organelle is responsible for the synthesis of secretory proteins in the cell?

  • Rough endoplasmic reticulum (correct)
  • Golgi complex
  • Nuclear envelope
  • Smooth endoplasmic reticulum

Where does protein folding primarily occur in the cell?

  • Rough endoplasmic reticulum (correct)
  • Nuclear envelope
  • Smooth endoplasmic reticulum
  • Golgi complex

Which organelle is responsible for the synthesis of lipids in the cell?

  • Smooth endoplasmic reticulum (correct)
  • Rough endoplasmic reticulum
  • Nuclear envelope
  • Golgi complex

Which organelle is responsible for protein processing and sorting in the cell?

<p>Golgi complex (B)</p> Signup and view all the answers

Which organelle is well developed in striated muscle and is responsible for calcium storage and release?

<p>Sarcoplasmic reticulum (C)</p> Signup and view all the answers

Where does the synthesis of lipids occur in the SER?

<p>Cytosol (A)</p> Signup and view all the answers

Which organelle is responsible for the phosphorylation of N-linked oligosaccharides on lysosomal proteins?

<p>Golgi complex (A)</p> Signup and view all the answers

Where does the sulfation of proteins mainly occur in the Golgi complex?

<p>Trans Golgi network (A)</p> Signup and view all the answers

Which type of vesicle is responsible for the anterograde transport of vesicles from the transitional RER to the cis Golgi network?

<p>COPII (D)</p> Signup and view all the answers

What is the function of adaptor proteins in vesicular trafficking?

<p>To bind to sorting sequences in transmembrane proteins (B)</p> Signup and view all the answers

Which sorting sequence is responsible for the transport of cargo proteins from the trans Golgi network to the late endosome?

<p>Mannose-6-P (A)</p> Signup and view all the answers

What is the role of Dynamin in vesicular trafficking?

<p>To pinch off the budding transport vesicle (C)</p> Signup and view all the answers

Which of the following is true about multi-pass transmembrane proteins?

<p>They contain a series of transmembrane spanning domains derived from alternating ISS and Stop Transfer Sequences (STS) (C)</p> Signup and view all the answers

What happens when the 1st ISS is generated in the polypeptide during translation?

<p>Translation pauses and the ISS binds to SRP (D)</p> Signup and view all the answers

What happens when the 2nd ISS is generated in the polypeptide during translation?

<p>Translation pauses and the ISS binds to SRP (C)</p> Signup and view all the answers

What is the function of chaperones in protein folding in the RER?

<p>Assist in the proper folding of newly synthesized polypeptides into the correct tertiary structure (D)</p> Signup and view all the answers

Which of the following is true about the rough endoplasmic reticulum (RER)?

<p>RER is involved in protein synthesis and secretion. (B)</p> Signup and view all the answers

Which organelle is continuous with the outer membrane of the nuclear envelope?

<p>Rough endoplasmic reticulum (RER) (A)</p> Signup and view all the answers

What is the function of chaperones and Protein Disulfide Isomerase (PDI) in the rough endoplasmic reticulum (RER)?

<p>To modify proteins (C)</p> Signup and view all the answers

Which of the following is true about the Golgi complex?

<p>The Golgi complex consists of cis Golgi network, medial and trans Golgi stacks, and trans Golgi network. (D)</p> Signup and view all the answers

Which proteins facilitate tethering of the target membrane during vesicular trafficking?

<p>v-SNARE and t-SNARE proteins (D)</p> Signup and view all the answers

Which process involves GTP hydrolysis and membrane fusion?

<p>Exocytosis (D)</p> Signup and view all the answers

Where are secretory proteins synthesized?

<p>Cytosol (B)</p> Signup and view all the answers

Which organelle is responsible for the formation of secretory granules?

<p>Golgi cisternae (A)</p> Signup and view all the answers

What is the appearance of mature secretory granules?

<p>Bullseye (B)</p> Signup and view all the answers

Where do secretory granules release their contents?

<p>Extracellular space (D)</p> Signup and view all the answers

Which of the following is true about the synthesis of secretory proteins in the rough endoplasmic reticulum (RER)?

<p>Translating ribosomes are attached to the RER membrane (C)</p> Signup and view all the answers

Which of the following is true about the signal recognition particle (SRP) in the synthesis of secretory proteins in the RER?

<p>SRP is a ribonucleoprotein consisting of 3 proteins and a small cytoplasmic RNA (B)</p> Signup and view all the answers

Which of the following is true about transmembrane proteins in the RER?

<p>Transmembrane proteins have hydrophilic domains that are inserted into the RER membrane (A)</p> Signup and view all the answers

Which of the following is true about single-pass transmembrane proteins in the RER?

<p>The internal signal sequence functions as a transmembrane domain (B)</p> Signup and view all the answers

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