30 Questions
Which organelle is responsible for the synthesis of secretory proteins in the cell?
Rough endoplasmic reticulum
Where does protein folding primarily occur in the cell?
Rough endoplasmic reticulum
Which organelle is responsible for the synthesis of lipids in the cell?
Smooth endoplasmic reticulum
Which organelle is responsible for protein processing and sorting in the cell?
Golgi complex
Which organelle is well developed in striated muscle and is responsible for calcium storage and release?
Sarcoplasmic reticulum
Where does the synthesis of lipids occur in the SER?
Cytosol
Which organelle is responsible for the phosphorylation of N-linked oligosaccharides on lysosomal proteins?
Golgi complex
Where does the sulfation of proteins mainly occur in the Golgi complex?
Trans Golgi network
Which type of vesicle is responsible for the anterograde transport of vesicles from the transitional RER to the cis Golgi network?
COPII
What is the function of adaptor proteins in vesicular trafficking?
To bind to sorting sequences in transmembrane proteins
Which sorting sequence is responsible for the transport of cargo proteins from the trans Golgi network to the late endosome?
Mannose-6-P
What is the role of Dynamin in vesicular trafficking?
To pinch off the budding transport vesicle
Which of the following is true about multi-pass transmembrane proteins?
They contain a series of transmembrane spanning domains derived from alternating ISS and Stop Transfer Sequences (STS)
What happens when the 1st ISS is generated in the polypeptide during translation?
Translation pauses and the ISS binds to SRP
What happens when the 2nd ISS is generated in the polypeptide during translation?
Translation pauses and the ISS binds to SRP
What is the function of chaperones in protein folding in the RER?
Assist in the proper folding of newly synthesized polypeptides into the correct tertiary structure
Which of the following is true about the rough endoplasmic reticulum (RER)?
RER is involved in protein synthesis and secretion.
Which organelle is continuous with the outer membrane of the nuclear envelope?
Rough endoplasmic reticulum (RER)
What is the function of chaperones and Protein Disulfide Isomerase (PDI) in the rough endoplasmic reticulum (RER)?
To modify proteins
Which of the following is true about the Golgi complex?
The Golgi complex consists of cis Golgi network, medial and trans Golgi stacks, and trans Golgi network.
Which proteins facilitate tethering of the target membrane during vesicular trafficking?
v-SNARE and t-SNARE proteins
Which process involves GTP hydrolysis and membrane fusion?
Exocytosis
Where are secretory proteins synthesized?
Cytosol
Which organelle is responsible for the formation of secretory granules?
Golgi cisternae
What is the appearance of mature secretory granules?
Bullseye
Where do secretory granules release their contents?
Extracellular space
Which of the following is true about the synthesis of secretory proteins in the rough endoplasmic reticulum (RER)?
Translating ribosomes are attached to the RER membrane
Which of the following is true about the signal recognition particle (SRP) in the synthesis of secretory proteins in the RER?
SRP is a ribonucleoprotein consisting of 3 proteins and a small cytoplasmic RNA
Which of the following is true about transmembrane proteins in the RER?
Transmembrane proteins have hydrophilic domains that are inserted into the RER membrane
Which of the following is true about single-pass transmembrane proteins in the RER?
The internal signal sequence functions as a transmembrane domain
Test your knowledge on the pathways and regulation of exocytosis with this quiz. Explore topics such as the maturation of secretory granules and the lysosome pathway.
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