Protein Synthesis I,II
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Questions and Answers

Which organelle is responsible for the synthesis of secretory proteins in the cell?

  • Rough endoplasmic reticulum (correct)
  • Golgi complex
  • Nuclear envelope
  • Smooth endoplasmic reticulum
  • Where does protein folding primarily occur in the cell?

  • Rough endoplasmic reticulum (correct)
  • Nuclear envelope
  • Smooth endoplasmic reticulum
  • Golgi complex
  • Which organelle is responsible for the synthesis of lipids in the cell?

  • Smooth endoplasmic reticulum (correct)
  • Rough endoplasmic reticulum
  • Nuclear envelope
  • Golgi complex
  • Which organelle is responsible for protein processing and sorting in the cell?

    <p>Golgi complex</p> Signup and view all the answers

    Which organelle is well developed in striated muscle and is responsible for calcium storage and release?

    <p>Sarcoplasmic reticulum</p> Signup and view all the answers

    Where does the synthesis of lipids occur in the SER?

    <p>Cytosol</p> Signup and view all the answers

    Which organelle is responsible for the phosphorylation of N-linked oligosaccharides on lysosomal proteins?

    <p>Golgi complex</p> Signup and view all the answers

    Where does the sulfation of proteins mainly occur in the Golgi complex?

    <p>Trans Golgi network</p> Signup and view all the answers

    Which type of vesicle is responsible for the anterograde transport of vesicles from the transitional RER to the cis Golgi network?

    <p>COPII</p> Signup and view all the answers

    What is the function of adaptor proteins in vesicular trafficking?

    <p>To bind to sorting sequences in transmembrane proteins</p> Signup and view all the answers

    Which sorting sequence is responsible for the transport of cargo proteins from the trans Golgi network to the late endosome?

    <p>Mannose-6-P</p> Signup and view all the answers

    What is the role of Dynamin in vesicular trafficking?

    <p>To pinch off the budding transport vesicle</p> Signup and view all the answers

    Which of the following is true about multi-pass transmembrane proteins?

    <p>They contain a series of transmembrane spanning domains derived from alternating ISS and Stop Transfer Sequences (STS)</p> Signup and view all the answers

    What happens when the 1st ISS is generated in the polypeptide during translation?

    <p>Translation pauses and the ISS binds to SRP</p> Signup and view all the answers

    What happens when the 2nd ISS is generated in the polypeptide during translation?

    <p>Translation pauses and the ISS binds to SRP</p> Signup and view all the answers

    What is the function of chaperones in protein folding in the RER?

    <p>Assist in the proper folding of newly synthesized polypeptides into the correct tertiary structure</p> Signup and view all the answers

    Which of the following is true about the rough endoplasmic reticulum (RER)?

    <p>RER is involved in protein synthesis and secretion.</p> Signup and view all the answers

    Which organelle is continuous with the outer membrane of the nuclear envelope?

    <p>Rough endoplasmic reticulum (RER)</p> Signup and view all the answers

    What is the function of chaperones and Protein Disulfide Isomerase (PDI) in the rough endoplasmic reticulum (RER)?

    <p>To modify proteins</p> Signup and view all the answers

    Which of the following is true about the Golgi complex?

    <p>The Golgi complex consists of cis Golgi network, medial and trans Golgi stacks, and trans Golgi network.</p> Signup and view all the answers

    Which proteins facilitate tethering of the target membrane during vesicular trafficking?

    <p>v-SNARE and t-SNARE proteins</p> Signup and view all the answers

    Which process involves GTP hydrolysis and membrane fusion?

    <p>Exocytosis</p> Signup and view all the answers

    Where are secretory proteins synthesized?

    <p>Cytosol</p> Signup and view all the answers

    Which organelle is responsible for the formation of secretory granules?

    <p>Golgi cisternae</p> Signup and view all the answers

    What is the appearance of mature secretory granules?

    <p>Bullseye</p> Signup and view all the answers

    Where do secretory granules release their contents?

    <p>Extracellular space</p> Signup and view all the answers

    Which of the following is true about the synthesis of secretory proteins in the rough endoplasmic reticulum (RER)?

    <p>Translating ribosomes are attached to the RER membrane</p> Signup and view all the answers

    Which of the following is true about the signal recognition particle (SRP) in the synthesis of secretory proteins in the RER?

    <p>SRP is a ribonucleoprotein consisting of 3 proteins and a small cytoplasmic RNA</p> Signup and view all the answers

    Which of the following is true about transmembrane proteins in the RER?

    <p>Transmembrane proteins have hydrophilic domains that are inserted into the RER membrane</p> Signup and view all the answers

    Which of the following is true about single-pass transmembrane proteins in the RER?

    <p>The internal signal sequence functions as a transmembrane domain</p> Signup and view all the answers

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