PATH L1C | Exocrine Pancreas Pathologies

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18 Questions

What is the most common congenital anomaly of the pancreas?

Pancreas divisum

What is the incidence of pancreas divisum?

3% to 10%

What causes pancreas divisum?

Failure of fusion of the fetal duct systems of the dorsal and ventral pancreatic primordia

What percentage of individuals with pancreas divisum are asymptomatic?

95%

What is the main cause of acute or chronic pancreatitis in individuals with pancreas divisum?

Inadequate drainage of pancreatic secretions through the minor papilla

Which duct drains only a small portion of the head of the gland through the papilla of Vater in individuals with pancreas divisum?

The duct of Wirsung

Which of the following is a common cause of acute pancreatitis in the United States?

Gallstones impaction

What is the approximate overall mortality rate for acute pancreatitis?

5%

What is the estimated annual incidence of acute pancreatitis globally?

33 to 74 per 100,000

What is the most common cause of chronic pancreatitis?

Chronic excessive alcohol consumption

What is the prevalence range of chronic pancreatitis in the U.S. population?

1% to 5%

What is the approximate 5-year survival rate for pancreatic carcinoma?

8%

What are the most common antecedent lesions of pancreatic cancer called?

Pancreatic intraepithelial neoplasias (PanINs)

What role does aberrant function of the cystic fibrosis transmembrane conductance regulator (CFTR) play in pancreatic disease?

It affects the biochemical content and viscosity of pancreatic secretions

What are the most common cause of acute pancreatitis and chronic pancreatitis respectively?

Gallstones, alcohol

Which gene mutations are often found to be mutated in familial acute pancreatitis?

PRRS1, SPINK1

What is the female-to-male ratio for serous cystadenomas?

2 : 1

What percentage of all pancreatic cysts are neoplastic?

5% to 15%

Test your knowledge about the different manifestations and diagnoses of exocrine pancreatic pathologies, including congenital malformations such as pancreas divisum. Learn to interpret clinical features and relevant studies for diagnosis.

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