Eutherian Mammals
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Questions and Answers

Which of the following is a mechanism of fetal tolerance in pregnant mammals?

  • Exclusion of inflammatory cells from the pregnant uterus (correct)
  • Generation of harmful Th1 responses in the healthy pregnant uterus
  • Decreased generation of peripheral regulatory T cells
  • Increased antigen presentation in the placenta

    • What is the consequence of the failure of self-tolerance?

  • Development of autoimmunity (correct)
  • Generation of peripheral FoxP3+ regulatory T cells
  • Increased antigen presentation in the placenta
  • Exclusion of inflammatory cells from the pregnant uterus

    • What is the correlation between placentation and the ability to generate stable peripheral regulatory T cells?

  • No correlation
  • Weak correlation
  • Negative correlation
  • Strong correlation (correct)

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