Etiopathogenesis of Periodontal Diseases

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What is the main reason why periodontal diseases are not considered infections caused by specific bacteria?

The bacteria responsible for periodontal diseases are not specific.

The prolonged accumulation of undisturbed subgingival plaque causes acute inflammation.

The inflammatory molecules released by bacteria cause tissue breakdown.

The host response to the bacteria plays a vital role in disease development. (correct)

What is the result of very high levels of chemokines within periodontal tissues?

Activation of PMNs leading to release of lytic enzymes (correct)

Stimulation of macrophage-T cell axis

Inhibition of PMNs activity

Reduction in the release of inflammatory molecules

What is the consequence of bacterial metabolites stimulating the macrophage-T cell axis?

Alteration of resident fibroblasts (correct)

Reduction in MMPs secretion

Inhibition of chronic inflammation

Stimulation of acute inflammation

What is the primary cause of tissue breakdown in periodontal diseases according to the text?

Host's dysregulated inflammatory processes Signup and view all the answers

What role does prolonged accumulation of undisturbed subgingival plaque play in the development of periodontal diseases?

Causes release of inflammatory molecules leading to inflammatory reaction Signup and view all the answers

What happens when bacterial metabolites stimulate the macrophage-T cell axis according to the text?

Alters resident fibroblasts to secrete tissue-destroying secondary mediators Signup and view all the answers

What is the main result of dysregulated immune-inflammatory responses induced by plaque bacteria and their products?

Loss of attachment of gingival/PDL collagen fibers to the tooth surface Signup and view all the answers

Which bacterial product activates macrophages to produce cytokines such as IL-1 and TNF-α?

Lipopolysaccharides (LPS) Signup and view all the answers

What is the main function of MMPs in the context of periodontal disease?

Destruction of collagen fibers and extracellular matrix components Signup and view all the answers

Which component is a key regulator of bone remodeling and directly involved in the differentiation, activation, and survival of osteoclast precursors & osteoclasts?

RANKL Signup and view all the answers

What determines and modifies the immune response in host susceptibility to periodontal diseases?

Host susceptibility Signup and view all the answers

What is the result of persistent plaque biofilm in a susceptible host?

Tissue destruction and CAL Signup and view all the answers

What leads to the activation of osteoclastic cells to secrete enzymes that work to destroy the inorganic mineralized components of bone?

PGE2 Signup and view all the answers

Which system's conversion of osteoclastic precursors to osteoclasts is highly dependent on PGE2?

RANK/RANKL/OPG system Signup and view all the answers

What is the main role of RANKL in bone remodeling?

Key regulator of bone remodeling and directly involved in osteoclast differentiation Signup and view all the answers

What causes the production of excessive amounts of collagen-destroying enzymes like MMPs and inflammatory mediators like PGE2?

Bacterial products (e.g. LPS) Signup and view all the answers

Etiopathogenesis of Periodontal Diseases

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