12 Questions
What is the primary advantage of using nonoral estrogens?
They avoid first pass metabolism and result in a more physiologic estradiol : estrone ratio
What is the main component of conjugated equine estrogens?
Estrone sulfate
What is the effect of oral estradiol on estrone concentrations?
It increases estrone concentrations three to six times
What is the result of using transdermal estrogen dosage forms?
A decrease in sex hormone–binding globulin, triglycerides, and blood pressure
What is the indication for Femring?
Moderate to severe vasomotor symptoms
What is the trend in recent evidence regarding estrogen doses?
Lower doses of estrogens are effective in controlling postmenopausal symptoms and reducing bone loss
What is a common adverse effect of estrogen therapy?
Nausea
Which type of estrogen therapy is less likely to cause breast tenderness and gallbladder disease?
Transdermal estrogen
What is a contraindication for MHT?
Personal history of breast cancer
What is the increased risk associated with combined oral MHT containing estrogen and progestogen?
Venous thromboembolism and stroke
What is the effect of estrogen alone on endometrial cancer risk in individuals with an intact uterus?
Increases the risk
What is the effect of combined estrogen and progestogen therapy on dementia in postmenopausal individuals 65 years or older?
Increases the risk
This quiz covers the different routes of administration and types of estrogens used in hormone replacement therapy, including conjugated equine estrogens and estradiol. Learn about the metabolism and effects of these estrogens in the body. Test your knowledge of estrogen therapy!
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