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Estradiol and Female Reproductive System Quiz

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Estradiol and Female Reproductive System Quiz

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Questions and Answers

What is the primary function of estradiol in females?

Stimulate the production of FSH

Inhibit the release of FSH

Prevent the formation of primary sex characteristics

Promote the development of secondary sex characteristics (correct)

How does high levels of estradiol affect the levels of FSH?

Positively feedback effect leading to increased FSH levels

Causes secretion of FSH

No effect on FSH levels

Negatively feedback effect leading to reduced FSH levels (correct)

What is the consequence of high levels of estradiol on ovulation?

Stimulate ovulation

Have no effect on ovulation

Prevent ovulation (correct)

Delay ovulation

Why is estradiol not suitable for use as an oral birth control?

It is orally inactive and rapidly metabolized by intestinal bacteria and during the first pass effect. Signup and view all the answers

How is the oral inactivity of estradiol overcome in oral contraceptive pills?

By using alpha phase protected ethinyl derivatives. Signup and view all the answers

What is the primary mechanism of action for the contraceptive effect of ethinyl estradiol and mestranol?

-ve feed-back effect on FSH and LH levels, reducing ovulation. Signup and view all the answers

Study Notes

Estradiol in Females

Primary function of estradiol in females: regulates growth and development of female sexual characteristics, maintains pregnancy, and regulates menstrual cycle

Effects of High Estradiol Levels

High levels of estradiol decrease FSH (follicle-stimulating hormone) levels via negative feedback mechanism
Consequence of high estradiol levels on ovulation: inhibits ovulation by preventing LH (luteinizing hormone) surge

Estradiol as Oral Birth Control

Estradiol is not suitable for use as an oral birth control due to its rapid metabolism and inactivation in the liver, resulting in low bioavailability
Oral inactivity of estradiol is overcome in oral contraceptive pills by:
- Alkylation at C17 position, which reduces first-pass metabolism and increases bioavailability
- Conversion of estradiol to ethinyl estradiol and mestranol, which are more resistant to metabolism

Contraceptive Effect of Ethinyl Estradiol and Mestranol

Primary mechanism of action for contraceptive effect: inhibition of ovulation by suppressing FSH and LH secretion, and thickening of cervical mucus, making it difficult for sperm to penetrate

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Description

Test your knowledge about the role of estradiol in the female reproductive system, including its impact on primary and secondary sex characteristics, FSH secretion, and contraception.