Escherichia coli (E. coli) Pathogenesis: EPEC

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What type of island is associated with the pathogenesis of EPEC?

Enterocyte effacement island

Gut epithelial island

Pathogenicity island (correct)

Chromosomal island

What is the function of BFP pili in some EPEC strains?

To affect Ca2+ and Cl- concentrations

To translocate receptors and adhesins

To adhere to gut epithelial cells (correct)

To form pedestals beneath E. coli

What is the main difference between EPEC and RPEC?

RPEC is a type of EPEC with an eae gene (correct)

EPEC affects small intestines, while RPEC affects large intestines

RPEC affects rabbits, while EPEC affects humans

RPEC is more virulent than EPEC

What is the effect of EPEC on gut epithelial cells?

It triggers a cascade of intracellular reactions (A) Signup and view all the answers

What is the primary cause of diarrhea in suckling rabbits infected with RPEC?

Lesions in the small and large intestines (A) Signup and view all the answers

What is the mortality rate associated with EPEC in rabbits?

25-40% (C) Signup and view all the answers

What is the typical location of lesions in the intestine associated with E. coli?

Small intestine (D) Signup and view all the answers

What is the primary mechanism of action of Shiga toxins in humans?

Blocking protein synthesis by inhibiting ribosomal peptide elongation (D) Signup and view all the answers

What is the role of Shiga toxin in E. coli infections?

It inhibits protein synthesis in host cells (C) Signup and view all the answers

What is the primary source of E. coli O157:H7 in humans?

Contaminated food from bovines (A) Signup and view all the answers

What is the primary association of E. coli O139 and O141 strains?

They are usually hemolytic and produce Shiga toxin (B) Signup and view all the answers

What is the name of the syndrome caused by Shiga toxins in humans?

Hemolytic uremic syndrome (HUS) (B) Signup and view all the answers

What is the target cell type for the Shiga toxin Stx2e in oedema disease in pigs?

Endothelial cells of the small arteries (A) Signup and view all the answers

What is the primary benefit of vaccination in preventing E. coli infections?

It reduces the predisposing factors for E. coli infections (C) Signup and view all the answers

What is the name of the gene responsible for the production of Shiga toxins in E. coli?

Shiga toxin gene (stx1 or stx2) (B) Signup and view all the answers

What is the preferred treatment for E. coli infections?

Hydration, oral electrolytes, and antimicrobial therapy (B) Signup and view all the answers

What is the name of the E. coli category that includes UPEC, SEPEC, and NTEC?

Extraintestinal pathogenic E. coli (ExPEC) (B) Signup and view all the answers

In dogs, what is the primary symptom of HUS?

Bloody diarrhea (B) Signup and view all the answers

What is the primary concern in treating severe mastitis caused by Escherichia coli?

LPS-induced shock (C) Signup and view all the answers

Which of the following antibiotics has been shown to have beneficial effects in treating MPEC infections?

Fluoroquinolones (C) Signup and view all the answers

What is the primary cause of the Metritis-Mastitis-Agalactiae (MMA) syndrome in pigs?

Multifactorial etiology (B) Signup and view all the answers

What is a common clinical sign of Post Partum Dysgalactiae Syndrome (PPDS) in pigs?

Reluctance to nurse (B) Signup and view all the answers

What is the effect of MMA syndrome on piglets?

Lower weight gain (B) Signup and view all the answers

What is the primary mechanism by which UPEC E. coli causes cellular destruction in the urinary tract?

Through the release of hemolysins that damage red blood cells and other cells (D) Signup and view all the answers

What is the purpose of administering antibiotics at night in the treatment of canine UTIs?

To target the increased bacterial activity at night (A) Signup and view all the answers

What is the primary difference between sporadic and recurrent UTIs in large animals?

Recurrent UTIs occur more frequently in large animals (B) Signup and view all the answers

What is the role of cranberry proanthocyanidins in the treatment of UTIs?

They inhibit the adhesion of E. coli to the uroepithelium (A) Signup and view all the answers

What is the primary cause of pyometra in bitches?

Hormonal changes in the female's reproductive tract (A) Signup and view all the answers

What is the percentage of pyometra cases in which E. coli is isolated?

58% to 88% (D) Signup and view all the answers