Escherichia coli (E. coli) Pathogenesis: EPEC
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Questions and Answers

What type of island is associated with the pathogenesis of EPEC?

  • Enterocyte effacement island
  • Gut epithelial island
  • Pathogenicity island (correct)
  • Chromosomal island
  • What is the function of BFP pili in some EPEC strains?

  • To affect Ca2+ and Cl- concentrations
  • To translocate receptors and adhesins
  • To adhere to gut epithelial cells (correct)
  • To form pedestals beneath E. coli
  • What is the main difference between EPEC and RPEC?

  • RPEC is a type of EPEC with an eae gene (correct)
  • EPEC affects small intestines, while RPEC affects large intestines
  • RPEC affects rabbits, while EPEC affects humans
  • RPEC is more virulent than EPEC
  • What is the effect of EPEC on gut epithelial cells?

    <p>It triggers a cascade of intracellular reactions</p> Signup and view all the answers

    What is the primary cause of diarrhea in suckling rabbits infected with RPEC?

    <p>Lesions in the small and large intestines</p> Signup and view all the answers

    What is the mortality rate associated with EPEC in rabbits?

    <p>25-40%</p> Signup and view all the answers

    What is the typical location of lesions in the intestine associated with E. coli?

    <p>Small intestine</p> Signup and view all the answers

    What is the primary mechanism of action of Shiga toxins in humans?

    <p>Blocking protein synthesis by inhibiting ribosomal peptide elongation</p> Signup and view all the answers

    What is the role of Shiga toxin in E. coli infections?

    <p>It inhibits protein synthesis in host cells</p> Signup and view all the answers

    What is the primary source of E. coli O157:H7 in humans?

    <p>Contaminated food from bovines</p> Signup and view all the answers

    What is the primary association of E. coli O139 and O141 strains?

    <p>They are usually hemolytic and produce Shiga toxin</p> Signup and view all the answers

    What is the name of the syndrome caused by Shiga toxins in humans?

    <p>Hemolytic uremic syndrome (HUS)</p> Signup and view all the answers

    What is the target cell type for the Shiga toxin Stx2e in oedema disease in pigs?

    <p>Endothelial cells of the small arteries</p> Signup and view all the answers

    What is the primary benefit of vaccination in preventing E. coli infections?

    <p>It reduces the predisposing factors for E. coli infections</p> Signup and view all the answers

    What is the name of the gene responsible for the production of Shiga toxins in E. coli?

    <p>Shiga toxin gene (stx1 or stx2)</p> Signup and view all the answers

    What is the preferred treatment for E. coli infections?

    <p>Hydration, oral electrolytes, and antimicrobial therapy</p> Signup and view all the answers

    What is the name of the E. coli category that includes UPEC, SEPEC, and NTEC?

    <p>Extraintestinal pathogenic E. coli (ExPEC)</p> Signup and view all the answers

    In dogs, what is the primary symptom of HUS?

    <p>Bloody diarrhea</p> Signup and view all the answers

    What is the primary concern in treating severe mastitis caused by Escherichia coli?

    <p>LPS-induced shock</p> Signup and view all the answers

    Which of the following antibiotics has been shown to have beneficial effects in treating MPEC infections?

    <p>Fluoroquinolones</p> Signup and view all the answers

    What is the primary cause of the Metritis-Mastitis-Agalactiae (MMA) syndrome in pigs?

    <p>Multifactorial etiology</p> Signup and view all the answers

    What is a common clinical sign of Post Partum Dysgalactiae Syndrome (PPDS) in pigs?

    <p>Reluctance to nurse</p> Signup and view all the answers

    What is the effect of MMA syndrome on piglets?

    <p>Lower weight gain</p> Signup and view all the answers

    What is the primary mechanism by which UPEC E. coli causes cellular destruction in the urinary tract?

    <p>Through the release of hemolysins that damage red blood cells and other cells</p> Signup and view all the answers

    What is the purpose of administering antibiotics at night in the treatment of canine UTIs?

    <p>To target the increased bacterial activity at night</p> Signup and view all the answers

    What is the primary difference between sporadic and recurrent UTIs in large animals?

    <p>Recurrent UTIs occur more frequently in large animals</p> Signup and view all the answers

    What is the role of cranberry proanthocyanidins in the treatment of UTIs?

    <p>They inhibit the adhesion of E. coli to the uroepithelium</p> Signup and view all the answers

    What is the primary cause of pyometra in bitches?

    <p>Hormonal changes in the female's reproductive tract</p> Signup and view all the answers

    What is the percentage of pyometra cases in which E. coli is isolated?

    <p>58% to 88%</p> Signup and view all the answers

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