15 Questions
What is the most important factor responsible for anemia in CKD?
Decreased erythropoietin production
What is the prevalence of anemia among patients with a GFR less than 15 mL/minute?
75%
When should the evaluation for anemia be initiated in CKD according to the text?
When hemoglobin is less than 13 g/dL (men) or less than 12 g/dL (women)
Which of the following is a treatment for anemia in CKD as mentioned in the text?
Erythropoiesis-stimulating agents (ESAs)
What is the advantage of Methoxy polyethylene glycolProcrit and epoetin beta over Epoetin alfa?
Less-frequent dosing
What is the recommended dosage of erythropoiesis-stimulating agents (ESA) for non-dialysis patients with chronic kidney disease (CKD) when their hemoglobin is greater than 10 g/dL?
Hold or reduce the dose
When does the onset of hemoglobin increase occur after the initial dose of Mircera according to the text?
7-15 days
What is the most common cause of erythropoietin resistance in patients receiving ESA therapy for CKD?
Iron deficiency
What is the main cause of morbidity and mortality in patients undergoing dialysis due to chronic kidney disease-mineral and bone disorder (CKD-MBD)?
Vascular calcification
What are the consequences of CKD-MBD?
Renal osteodystrophy and vascular calcification
What is a recommended nondrug therapy for CKD-MBD?
Restricting dietary phosphorus
What is the therapy goal for erythropoiesis-stimulating agents in patients with CKD?
To prevent blood transfusion
What is the recommended cumulative or total dose of iron for adult patients undergoing dialysis?
$1000 mg
Which factor directly stimulates parathyroid hormone (PTH) secretion and elevates PTH concentrations in CKD-MBD?
Hyperphosphatemia
What should be monitored during erythropoietic therapy in patients with CKD?
$1,25-dihydroxyvitamin D3 & ferritin levels
Test your knowledge of dosing requirements for erythropoiesis-stimulating agents (ESA) used in the treatment of anemia. Explore the dosage calculations, administration methods, and therapy goals associated with ESA.
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