Erythropoiesis and Hemoglobin Structure Quiz
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Questions and Answers

What is a characteristic feature of megaloblastic anemia?

  • Presence of hypersegmented neutrophils (correct)
  • Increase in absolute reticulocyte count
  • Decrease in RDW levels
  • Decrease in LDH levels

    • Which test is a good indicator of accelerated hemolysis?

  • Leach phenotype test
  • EMA binding test
  • Confirmatory test for Hereditary Spherocytosis
  • Autohemolysis test (correct)

    • What is a typical finding in Thrombotic Thrombocytopenic Purpura (TTP)?

  • Presence of Schistocytes (correct)
  • Normal platelet count
  • Thrombocytosis
  • High ADAMTS-13 levels

    • Which gene mutation is associated with Congenital Dyserythropoietic Anemia type 2 (CDA2)?

    <p>SEC23B gene</p> Signup and view all the answers

    What is a confirmatory test for Paroxysmal Nocturnal Hemoglobinuria (PNH)?

    <p>Flow cytometry</p> Signup and view all the answers

    In Acquired Stomatocytosis, what are often seen as artifacts on Wright stain?

    <p>Burr cells</p> Signup and view all the answers

    What is the main reason hematopoietic stem cells (HSCs) can produce all lineages of blood cells throughout an individual's lifetime?

    <p>They have the ability to self-renew by asymmetric division.</p> Signup and view all the answers

    Approximately how many erythrocytes can bone marrow estimate producing per kg of body weight?

    <p>2.5 billion</p> Signup and view all the answers

    What is the estimated production of platelets per kg of body weight by bone marrow?

    <p>2.5 billion</p> Signup and view all the answers

    Which characteristic is NOT a criterion for red blood cell maturation?

    <p>Parachromatin presence</p> Signup and view all the answers

    What is the approximate duration taken by a BFU-E (burst-forming unit-erythroid) to mature?

    <p>18-21 days</p> Signup and view all the answers

    What is the pathophysiological mechanism behind the formation of platelet vWF thrombi in TTP?

    <p>Autoantibody to ADAMTS-13</p> Signup and view all the answers

    Which diagnostic test is commonly used for pernicious anemia?

    <p>Schillings test (uses radioactive Vit.B12)</p> Signup and view all the answers

    What type of Hemoglobin mutation is associated with Hgb S?

    <p>Glutamic acid to valine</p> Signup and view all the answers

    Which virus can cause a transient aplastic crisis in chronic hemolytic anemia?

    <p>Parvovirus B19 infection</p> Signup and view all the answers

    What is the characteristic feature of AIHA (Autoimmune Hemolytic Anemia)?

    <p>Increase OFT, DAT +</p> Signup and view all the answers

    Which condition results in the increase in the number of spherocytes in the blood?

    <p>Post-splenectomy</p> Signup and view all the answers

    What is the most preferable site for an adult to collect bone marrow?

    <p>Iliac crest</p> Signup and view all the answers

    Which phospholipid flips into the outer leaflet, playing a role in cell signaling?

    <p>Phosphatidylserine</p> Signup and view all the answers

    Where is the location of MN blood group antigens?

    <p>Glycophorin A</p> Signup and view all the answers

    Which chromosome location harbors the Alpha and Zeta genes?

    <p>Chromosome 16</p> Signup and view all the answers

    What is the primary physiological response to increased anemia demand?

    <p>Extramedullary hematopoiesis in the liver and spleen</p> Signup and view all the answers

    Which hormone is the master regulator of iron metabolism with a negative effect on RBC production?

    <p>Hepcidin</p> Signup and view all the answers

    What initiates an intracellular message to developing erythroid cells?

    <p>Erythropoietin (EPO)</p> Signup and view all the answers

    Where does iron need to be in order for hemoglobin to combine with oxygen?

    <p>Ferrous state (Fe2+)</p> Signup and view all the answers

    What physiological response occurs to meet the demand for increased anemia?

    <p>Extramedullary hematopoiesis in the liver and spleen</p> Signup and view all the answers

    What is characteristic of Hematopoietic Stem Cells (HSCs)?

    <p>Capable of cell renewal</p> Signup and view all the answers

    What is the primary regulator of erythropoiesis and where is it produced?

    <p>Erythropoietin in the kidney</p> Signup and view all the answers

    Which structure of hemoglobin has iron in the ferric state and is unable to carry oxygen?

    <p>Methemoglobin</p> Signup and view all the answers

    What is the main function of the enzyme GSH in red blood cells?

    <p>Neutralizes accumulating oxidants</p> Signup and view all the answers

    Which component is mainly responsible for lateral distribution during the passage of red blood cells through narrow capillaries?

    <p>Phospholipids and cholesterol</p> Signup and view all the answers

    What is the integral protein responsible for anchoring Band 3 and Protein 4.2 in red blood cells?

    <p>Glycophorin A</p> Signup and view all the answers

    What happens to red blood cells when phospholipids redistribute to the outer layer?

    <ul> <li>They are destroyed by macrophages</li> </ul> Signup and view all the answers

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