Erythropoiesis and Hemoglobin Structure Quiz
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Questions and Answers

What is a characteristic feature of megaloblastic anemia?

  • Presence of hypersegmented neutrophils (correct)
  • Increase in absolute reticulocyte count
  • Decrease in RDW levels
  • Decrease in LDH levels

Which test is a good indicator of accelerated hemolysis?

  • Leach phenotype test
  • EMA binding test
  • Confirmatory test for Hereditary Spherocytosis
  • Autohemolysis test (correct)

What is a typical finding in Thrombotic Thrombocytopenic Purpura (TTP)?

  • Presence of Schistocytes (correct)
  • Normal platelet count
  • Thrombocytosis
  • High ADAMTS-13 levels

Which gene mutation is associated with Congenital Dyserythropoietic Anemia type 2 (CDA2)?

<p>SEC23B gene (D)</p> Signup and view all the answers

What is a confirmatory test for Paroxysmal Nocturnal Hemoglobinuria (PNH)?

<p>Flow cytometry (A)</p> Signup and view all the answers

In Acquired Stomatocytosis, what are often seen as artifacts on Wright stain?

<p>Burr cells (D)</p> Signup and view all the answers

What is the main reason hematopoietic stem cells (HSCs) can produce all lineages of blood cells throughout an individual's lifetime?

<p>They have the ability to self-renew by asymmetric division. (D)</p> Signup and view all the answers

Approximately how many erythrocytes can bone marrow estimate producing per kg of body weight?

<p>2.5 billion (D)</p> Signup and view all the answers

What is the estimated production of platelets per kg of body weight by bone marrow?

<p>2.5 billion (D)</p> Signup and view all the answers

Which characteristic is NOT a criterion for red blood cell maturation?

<p>Parachromatin presence (D)</p> Signup and view all the answers

What is the approximate duration taken by a BFU-E (burst-forming unit-erythroid) to mature?

<p>18-21 days (B)</p> Signup and view all the answers

What is the pathophysiological mechanism behind the formation of platelet vWF thrombi in TTP?

<p>Autoantibody to ADAMTS-13 (A)</p> Signup and view all the answers

Which diagnostic test is commonly used for pernicious anemia?

<p>Schillings test (uses radioactive Vit.B12) (D)</p> Signup and view all the answers

What type of Hemoglobin mutation is associated with Hgb S?

<p>Glutamic acid to valine (A)</p> Signup and view all the answers

Which virus can cause a transient aplastic crisis in chronic hemolytic anemia?

<p>Parvovirus B19 infection (B)</p> Signup and view all the answers

What is the characteristic feature of AIHA (Autoimmune Hemolytic Anemia)?

<p>Increase OFT, DAT + (B)</p> Signup and view all the answers

Which condition results in the increase in the number of spherocytes in the blood?

<p>Post-splenectomy (B)</p> Signup and view all the answers

What is the most preferable site for an adult to collect bone marrow?

<p>Iliac crest (A)</p> Signup and view all the answers

Which phospholipid flips into the outer leaflet, playing a role in cell signaling?

<p>Phosphatidylserine (A)</p> Signup and view all the answers

Where is the location of MN blood group antigens?

<p>Glycophorin A (A)</p> Signup and view all the answers

Which chromosome location harbors the Alpha and Zeta genes?

<p>Chromosome 16 (C)</p> Signup and view all the answers

What is the primary physiological response to increased anemia demand?

<p>Extramedullary hematopoiesis in the liver and spleen (C)</p> Signup and view all the answers

Which hormone is the master regulator of iron metabolism with a negative effect on RBC production?

<p>Hepcidin (D)</p> Signup and view all the answers

What initiates an intracellular message to developing erythroid cells?

<p>Erythropoietin (EPO) (B)</p> Signup and view all the answers

Where does iron need to be in order for hemoglobin to combine with oxygen?

<p>Ferrous state (Fe2+) (B)</p> Signup and view all the answers

What physiological response occurs to meet the demand for increased anemia?

<p>Extramedullary hematopoiesis in the liver and spleen (C)</p> Signup and view all the answers

What is characteristic of Hematopoietic Stem Cells (HSCs)?

<p>Capable of cell renewal (C)</p> Signup and view all the answers

What is the primary regulator of erythropoiesis and where is it produced?

<p>Erythropoietin in the kidney (C)</p> Signup and view all the answers

Which structure of hemoglobin has iron in the ferric state and is unable to carry oxygen?

<p>Methemoglobin (B)</p> Signup and view all the answers

What is the main function of the enzyme GSH in red blood cells?

<p>Neutralizes accumulating oxidants (C)</p> Signup and view all the answers

Which component is mainly responsible for lateral distribution during the passage of red blood cells through narrow capillaries?

<p>Phospholipids and cholesterol (B)</p> Signup and view all the answers

What is the integral protein responsible for anchoring Band 3 and Protein 4.2 in red blood cells?

<p>Glycophorin A (A)</p> Signup and view all the answers

What happens to red blood cells when phospholipids redistribute to the outer layer?

<ul> <li>They are destroyed by macrophages (B)</li> </ul> Signup and view all the answers

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