Injectable Medications for Erectile Dysfunction
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Questions and Answers

What is the mechanism of action of alprostadil?

  • Inhibiting phosphodiesterase
  • Increasing urethral flow
  • Widening blood vessels (correct)
  • Enhancing lower urinary tract symptoms

Why is papaverine no longer available in the US and Canada?

  • Increased efficacy in treating ED
  • To avoid priapism risk
  • Development of more effective PDE-5 inhibitors (correct)
  • Due to high costs

What is the primary drawback of using MUSE for administering alprostadil?

  • Inability to bypass LUTS (correct)
  • High cost
  • Risk of priapism
  • Limited availability in pharmacies

Why is caution advised when using MUSE in patients with risk factors for priapism?

<p>Fibrosis potential after long-term use (D)</p> Signup and view all the answers

What percentage of patients using alprostadil successfully achieve intercourse according to studies?

<p>65-75% (D)</p> Signup and view all the answers

What is the main limitation of MUSE for men with erectile dysfunction caused by diabetes or radical prostate surgery?

<p>Limited efficacy (A)</p> Signup and view all the answers

What is the recommended maximum dosage of Papaverine in a 24-hour period?

<p>60mg (A)</p> Signup and view all the answers

Which medication has a success rate of 55-75% and comes in dosage strengths of 10, 20, or 40 μg per dose?

<p>Caverject (D)</p> Signup and view all the answers

What is the primary mechanism of action for Papaverine in treating erectile dysfunction?

<p>Inhibition of cAMP and cGMP phosphodiesterase (A)</p> Signup and view all the answers

Which medication combination has been shown to produce satisfactory erections in 60-70% of patients with chronic erectile dysfunction?

<p>Papaverine and Phentolamine (C)</p> Signup and view all the answers

What is a common side effect associated with Caverject usage?

<p>Prolonged erection (A)</p> Signup and view all the answers

Why is Phentolamine used in combination with Papaverine for erectile dysfunction treatment?

<p>To block receptors for erections (D)</p> Signup and view all the answers

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