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Questions and Answers
The approximate equivalent dose of Olanzapine is 20mg.
False
The approximate equivalent dose of Brexpiprazole is lower than that of Cariprazine.
True
Paliperidone LAI has an approximate equivalent dose of 100mg every month.
True
Asenapine has a higher approximate equivalent dose than Lurasidone.
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The approximate equivalent dose for Risperidone oral is the same as for Risperidone LAI.
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Clozapine is included in the equivalent doses for first-generation antipsychotics (FGAs) due to its similarity in dosage calculations.
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Equivalent doses of second-generation antipsychotics (SGAs) are deemed to be more clinically relevant than those of FGAs.
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100mg of chlorpromazine is approximately equivalent to 1.5mg of risperidone.
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The equivalent dose range for Flupentixol is widely accepted to be 10-20mg per week.
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Haloperidol's equivalent dose has a consensus value of 5mg per day based on clinical guidelines.
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There is considerable agreement among references cited about the exact equivalencies of FGAs.
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Fluphenazine depot has an equivalent dose range that varies from 1 to 12.5mg per week.
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Pimozide has a daily equivalent dosage consensus value of 2mg.
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Study Notes
Equivalent Doses of Antipsychotics
- Equivalent dose calculations are important for switching between First Generation Antipsychotics (FGAs)
- Equivalence estimates are based on clinical experience, expert opinion, and dopamine binding studies
- Table 1.2 provides a rough guide to approximate equivalent dosages of FGAs
- FGAs are typically titrated based on clinical response and side effects
- Equivalent doses for Second Generation Antipsychotics (SGAs) may be less important as these are usually prescribed within evidence-based dose ranges
- However, a very rough guide for SGAs is presented in Table 1.3
- Different methods can be used to estimate equivalence
- Equivalencies of FGAs and SGAs are more difficult to calculate
- Approximately, 100 mg of chlorpromazine is equivalent to 1.5 mg of risperidone.
- Clozapine is a unique case with specific titration protocols and high dose-plasma variability, so its equivalent dose is difficult to calculate
- The information given in the text should not be used in place of proper clinical judgment when titrating dosages.
First Generation Antipsychotic Equivalence Dosages
- The values provided for FGAs in Table 1.2 are approximations
- There are variations in the literature, especially in the range of values for each medication
- For example, the equivalent dose of fluphenazine ranges from 1-5 mg per day.
Second Generation Antipsychotic Equivalence Dosages
- There is information missing for Blonanserin, Lumateperone, Pimavanserin in Table 1.3
- This is because the equivalent doses for these were unknown at the time of the document's writing
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Description
This quiz covers the calculations of equivalent doses for First Generation and Second Generation Antipsychotics. It examines clinical practices, dosing estimates, and specific considerations for drugs like clozapine. Understanding these equivalences is crucial for effective patient management in psychiatric care.
