Podcast
Questions and Answers
What is lissencephaly and cerebellar hypoplasia (LCH) commonly associated with?
What is lissencephaly and cerebellar hypoplasia (LCH) commonly associated with?
- Infections during pregnancy
- Environmental factors leading to malformations
- Inherited conditions caused by genetic variants (correct)
- Nutritional deficiencies in mother sheep
Which of the following clinical signs was observed in the affected lambs with lissencephaly and cerebellar hypoplasia?
Which of the following clinical signs was observed in the affected lambs with lissencephaly and cerebellar hypoplasia?
- Isolation from the herd
- Increased appetite
- Enhanced visual acuity
- Hypermetric gait and intention tremors (correct)
What histological feature was notable in the cerebellar vermis of the affected lambs?
What histological feature was notable in the cerebellar vermis of the affected lambs?
- Disorganized and thin gray matter (correct)
- Reduction of gray matter in thalamus
- Marked hypercellularity
- Thickened granule cell layer
What method was used to confirm the pathological findings in the brains of the affected lambs?
What method was used to confirm the pathological findings in the brains of the affected lambs?
What is the aim of the study on neonatal encephalopathy in calves?
What is the aim of the study on neonatal encephalopathy in calves?
What characteristic finding was consistent across the pathological and genetic studies of RELN variants?
What characteristic finding was consistent across the pathological and genetic studies of RELN variants?
Which of the following discrepancies was noted in histological examination of the affected lambs?
Which of the following discrepancies was noted in histological examination of the affected lambs?
What is a common genetic factor linked to congenital neurological malformations such as LCH?
What is a common genetic factor linked to congenital neurological malformations such as LCH?
What condition were the ten foals identified with during phenotyping?
What condition were the ten foals identified with during phenotyping?
Which genetic mutation was one foal found to be a carrier of among those evaluated?
Which genetic mutation was one foal found to be a carrier of among those evaluated?
What is a proposed consequence of the p.Arg1681* variant in the CACNA1A gene?
What is a proposed consequence of the p.Arg1681* variant in the CACNA1A gene?
In which part of the body is the CACNA1A gene expressed as mentioned in the study?
In which part of the body is the CACNA1A gene expressed as mentioned in the study?
What does the absence of the CACNA1A variant in unaffected calves suggest?
What does the absence of the CACNA1A variant in unaffected calves suggest?
How many foals with juvenile idiopathic epilepsy were part of the EEG study?
How many foals with juvenile idiopathic epilepsy were part of the EEG study?
What was absent in all foals with juvenile idiopathic epilepsy except one?
What was absent in all foals with juvenile idiopathic epilepsy except one?
What is the purpose of the proposed standardized protocol for EEG in foals?
What is the purpose of the proposed standardized protocol for EEG in foals?
What percentage of the horses examined were considered clinically abnormal according to the observers?
What percentage of the horses examined were considered clinically abnormal according to the observers?
In the evaluation of neurologic abnormalities, what was the level of agreement among observers for lameness and ataxia?
In the evaluation of neurologic abnormalities, what was the level of agreement among observers for lameness and ataxia?
Regarding cranial nerve signs and involuntary movements, what was the agreement level among observers?
Regarding cranial nerve signs and involuntary movements, what was the agreement level among observers?
What percentage of horses showed contested status regarding their clinical examination?
What percentage of horses showed contested status regarding their clinical examination?
How many horses exhibited disagreement involving the severity of clinical signs?
How many horses exhibited disagreement involving the severity of clinical signs?
What was the level of agreement concerning the assessment of muscle atrophy and spasticity among observers?
What was the level of agreement concerning the assessment of muscle atrophy and spasticity among observers?
What is a painful neuropathic disorder in equines comparable to human trigeminal neuralgia?
What is a painful neuropathic disorder in equines comparable to human trigeminal neuralgia?
Which anatomical area was focused on in the study preparing for a controlled glycerol rhizotomy in horses?
Which anatomical area was focused on in the study preparing for a controlled glycerol rhizotomy in horses?
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Study Notes
Trigeminal Ganglion Anatomy
- Equine trigeminal-mediated headshaking is a painful neuropathic disorder comparable to trigeminal neuralgia in humans.
- The subarachnoid space surrounding the trigeminal ganglion in horses is being investigated for potential treatment of trigeminal-mediated headshaking with a controlled glycerol rhizotomy procedure.
- The study seeks to provide anatomical details of the subarachnoid space surrounding the trigeminal ganglion to facilitate a safer and more effective controlled glycerol rhizotomy procedure in equids.
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