Equine Anatomy of the Trigeminal Ganglion
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Questions and Answers

What is lissencephaly and cerebellar hypoplasia (LCH) commonly associated with?

  • Infections during pregnancy
  • Environmental factors leading to malformations
  • Inherited conditions caused by genetic variants (correct)
  • Nutritional deficiencies in mother sheep
  • Which of the following clinical signs was observed in the affected lambs with lissencephaly and cerebellar hypoplasia?

  • Isolation from the herd
  • Increased appetite
  • Enhanced visual acuity
  • Hypermetric gait and intention tremors (correct)
  • What histological feature was notable in the cerebellar vermis of the affected lambs?

  • Disorganized and thin gray matter (correct)
  • Reduction of gray matter in thalamus
  • Marked hypercellularity
  • Thickened granule cell layer
  • What method was used to confirm the pathological findings in the brains of the affected lambs?

    <p>Luxol fast blue stain and immunohistochemistry</p> Signup and view all the answers

    What is the aim of the study on neonatal encephalopathy in calves?

    <p>To identify risk factors and predictive factors for survival</p> Signup and view all the answers

    What characteristic finding was consistent across the pathological and genetic studies of RELN variants?

    <p>Dysplasia of cortical and cerebellar structures</p> Signup and view all the answers

    Which of the following discrepancies was noted in histological examination of the affected lambs?

    <p>Reduction in white matter</p> Signup and view all the answers

    What is a common genetic factor linked to congenital neurological malformations such as LCH?

    <p>Mutations in the RELN gene</p> Signup and view all the answers

    What condition were the ten foals identified with during phenotyping?

    <p>Juvenile idiopathic epilepsy</p> Signup and view all the answers

    Which genetic mutation was one foal found to be a carrier of among those evaluated?

    <p>Cerebellar abiotrophy</p> Signup and view all the answers

    What is a proposed consequence of the p.Arg1681* variant in the CACNA1A gene?

    <p>Haploinsufficiency leading to BFCA</p> Signup and view all the answers

    In which part of the body is the CACNA1A gene expressed as mentioned in the study?

    <p>Cerebellum</p> Signup and view all the answers

    What does the absence of the CACNA1A variant in unaffected calves suggest?

    <p>The variant does not segregate with the disease</p> Signup and view all the answers

    How many foals with juvenile idiopathic epilepsy were part of the EEG study?

    <p>10</p> Signup and view all the answers

    What was absent in all foals with juvenile idiopathic epilepsy except one?

    <p>Genetic mutations causing LFS, CA, SCID, and OAAM1</p> Signup and view all the answers

    What is the purpose of the proposed standardized protocol for EEG in foals?

    <p>To diagnose juvenile idiopathic epilepsy</p> Signup and view all the answers

    What percentage of the horses examined were considered clinically abnormal according to the observers?

    <p>61.9%</p> Signup and view all the answers

    In the evaluation of neurologic abnormalities, what was the level of agreement among observers for lameness and ataxia?

    <p>Good or excellent for 80% of horses</p> Signup and view all the answers

    Regarding cranial nerve signs and involuntary movements, what was the agreement level among observers?

    <p>Complete agreement</p> Signup and view all the answers

    What percentage of horses showed contested status regarding their clinical examination?

    <p>16.5%</p> Signup and view all the answers

    How many horses exhibited disagreement involving the severity of clinical signs?

    <p>31 horses</p> Signup and view all the answers

    What was the level of agreement concerning the assessment of muscle atrophy and spasticity among observers?

    <p>Good or excellent for 40%</p> Signup and view all the answers

    What is a painful neuropathic disorder in equines comparable to human trigeminal neuralgia?

    <p>Equine trigeminal-mediated headshaking</p> Signup and view all the answers

    Which anatomical area was focused on in the study preparing for a controlled glycerol rhizotomy in horses?

    <p>Trigeminal ganglion</p> Signup and view all the answers

    Study Notes

    Trigeminal Ganglion Anatomy

    • Equine trigeminal-mediated headshaking is a painful neuropathic disorder comparable to trigeminal neuralgia in humans.
    • The subarachnoid space surrounding the trigeminal ganglion in horses is being investigated for potential treatment of trigeminal-mediated headshaking with a controlled glycerol rhizotomy procedure.
    • The study seeks to provide anatomical details of the subarachnoid space surrounding the trigeminal ganglion to facilitate a safer and more effective controlled glycerol rhizotomy procedure in equids.

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    Description

    This quiz explores the anatomy of the trigeminal ganglion in horses and its relevance to trigeminal-mediated headshaking. It delves into the subarachnoid space and potential treatments like controlled glycerol rhizotomy. Gain insights into how anatomical details can improve clinical procedures in equids.

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