Eptifibatide - Integrilin Flashcards

Questions and Answers

What is the class for eptifibatide/integrilin?

Glycoprotein IIb/IIIa inhibitor, platelet aggregation inhibitor

What is the mechanism of action (MOA) for eptifibatide/integrilin?

Prevents the aggregation of platelets by binding to the glycoprotein receptor, preventing the binding of fibrinogen and von Willebrand factors

What are the indications for eptifibatide/integrilin?

Unstable angina and NSTEMI being managed medically. Patients undergoing percutaneous coronary intervention.

What are the contraindications for eptifibatide/integrilin?

Any prior intracranial hemorrhage, known malignant intracranial neoplasm, suspected aortic dissection, significant closed head trauma or facial trauma within 3 months, active internal bleeding or bleeding disorder in past 30 days, surgical procedure or trauma within preceding 6 weeks Signup and view all the answers

What are the adverse reactions/side effects for eptifibatide/integrilin?

Cerebral hemorrhage, pulmonary hemorrhage, hypotension, GI bleeding, internal bleeding, anaphylactic shock Signup and view all the answers

What are the drug interactions for eptifibatide/integrilin?

Thrombolytics, oral anticoagulants, aspirin, NSAIDs, dipyridamole, ticlopidine, and clopidogrel increase effect. Incompatible in the same IV line with furosemide (lasix) Signup and view all the answers

How is eptifibatide/integrilin supplied?

2mg/mL vials and 0.75mg/mL bottles Signup and view all the answers

What is the adult dosage for eptifibatide/integrilin?

180mcg/kg bolus over 1-2 mins followed by a 2mcg/kg infusion for 72-96 hours Signup and view all the answers

What is the pediatric dosage for eptifibatide/integrilin?

Not recommended Signup and view all the answers

What is the duration of action for eptifibatide/integrilin?

Onset: minutes, Peak: 30min-4hrs, Duration: platelet function recovers within 4-8 hours of discontinuation Signup and view all the answers

Study Notes

Eptifibatide - Integrilin Overview

Eptifibatide is classified as a glycoprotein IIb/IIIa inhibitor, specifically functioning as a platelet aggregation inhibitor.

Mechanism of Action (MOA)

Works by binding to the glycoprotein receptor, inhibiting platelet aggregation by blocking the binding of fibrinogen and von Willebrand factors.

Indications

Used in unstable angina and non-ST elevation myocardial infarction (NSTEMI) under medical management.
Indicated for patients who are undergoing percutaneous coronary intervention (PCI).

Contraindications

Contraindicated in individuals with a history of intracranial hemorrhage or known malignant intracranial neoplasm.
Not suitable for patients with suspected aortic dissection, significant closed head or facial trauma in the last three months, active internal bleeding, bleeding disorders in the past 30 days, or recent surgical procedures/trauma within six weeks.

Adverse Reactions/Side Effects

Potential side effects include cerebral hemorrhage, pulmonary hemorrhage, hypotension, gastrointestinal bleeding, internal bleeding, and anaphylactic shock.

Drug Interactions

Eptifibatide's effects can be enhanced by thrombolytics, oral anticoagulants, aspirin, NSAIDs, dipyridamole, ticlopidine, and clopidogrel.
It is incompatible with furosemide (Lasix) when administered in the same IV line.

Supply Information

Eptifibatide is available in 2mg/mL vials and 0.75mg/mL bottles.

Adult Dosage

Recommended initial dosage is a 180mcg/kg bolus over 1-2 minutes, followed by a continuous infusion of 2mcg/kg for 72-96 hours.

Pediatric Dosage

The use of eptifibatide for pediatric patients is not recommended.

Duration of Action

The onset of action occurs within minutes, with peak effects noted between 30 minutes to 4 hours.
Platelet function typically recovers within 4-8 hours after discontinuation of the drug.

Description

Test your knowledge on eptifibatide, also known as Integrilin, through these flashcards. Learn about its classification, mechanism of action, and clinical indications. This quick review is perfect for students and healthcare professionals alike.