Integrilin Overview and Mechanism of Action
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Questions and Answers

What are the indications for Integrilin?

  • Prevent blood clots from forming (correct)
  • Treat infections
  • Increase blood pressure
  • Decrease heart rate

Which of the following are contraindications for Integrilin? (Select all that apply)

  • CVA (correct)
  • Hypersensitivity (correct)
  • High blood pressure
  • History of internal bleeding (correct)

What is the mechanism of action of Integrilin?

It blocks the binding of fibrinogen and von Willebrand factor to glycoprotein IIb/IIIa receptor on platelet surface.

What is the generic name of Integrilin?

<p>Eptifibatide</p> Signup and view all the answers

What is the trade name of eptifibatide?

<p>Integrilin</p> Signup and view all the answers

For Acute Coronary Syndromes, the dosage is ___ mcg/kg IV bolus over 1-2 min.

<p>180</p> Signup and view all the answers

What is the route of administration for Integrilin?

<p>IV</p> Signup and view all the answers

What are some adverse reactions/side effects of Integrilin? (Select all that apply)

<p>Thrombocytopenia (A), Hypotension (B), Bleeding (D)</p> Signup and view all the answers

What classification does Integrilin belong to?

<p>Antiplatelet Agents</p> Signup and view all the answers

Study Notes

Integrilin Overview

  • Indication: Prevents the formation of blood clots, primarily used in acute coronary syndromes and during percutaneous coronary interventions.
  • Contraindications: Should not be used in patients with hypersensitivity, history of internal bleeding, intracranial hemorrhage or neoplasm, cerebrovascular accident (CVA), or thrombocytopenia.

Mechanism of Action

  • Action: Eptifibatide, the generic name for Integrilin, works by blocking the binding of fibrinogen and von Willebrand factor to the glycoprotein IIb/IIIa receptor on the surface of platelets, preventing platelet aggregation.

Administration and Dosage

  • Administered via: Intravenous (IV) route.
  • Dosage for Acute Coronary Syndromes: Initial IV bolus of 180 mcg/kg over 1-2 minutes, followed by a continuous IV infusion of 2 mcg/kg/min for up to 72 hours.
  • Dosage for Percutaneous Coronary Intervention: Initial IV bolus of 180 mcg/kg, followed by a continuous infusion of 2 mcg/kg/min and another IV bolus of 180 mcg/kg 10 minutes after the first.

Side Effects and Adverse Reactions

  • Common Adverse Reactions: May include bleeding, hypotension, and thrombocytopenia, which should be monitored closely.

Drug Classification

  • Classification: Integrilin is classified as an antiplatelet agent, designed to reduce clotting risk in the cardiovascular system.

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Description

This quiz covers the indications, contraindications, and mechanism of action of Integrilin, a medication used to prevent blood clots. It also details the administration route and appropriate dosages for acute coronary syndromes and percutaneous coronary interventions.

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