Podcast
Questions and Answers
Which of the following is NOT an epigenetic modification mentioned that regulates gene expression in human malignancies?
Which of the following is NOT an epigenetic modification mentioned that regulates gene expression in human malignancies?
- Alternative splicing (correct)
- Histone modifications
- MicroRNAs
- DNA methylation
What do abnormal metabolism and biochemical pathways, along with mutations in epigenetic actor genes, further demonstrate in cancer pathologies?
What do abnormal metabolism and biochemical pathways, along with mutations in epigenetic actor genes, further demonstrate in cancer pathologies?
- The exclusive role of genetics in cancer development
- The irrelevance of metabolism in cancer pathologies
- The relationship between genetics and epigenetics (correct)
- The exclusive role of epigenetics in cancer development
Which process involves the reorganization of nucleosomes to regulate gene expression?
Which process involves the reorganization of nucleosomes to regulate gene expression?
- Protein translation
- DNA replication
- RNA transcription
- Nucleosome remodeling (correct)
In the context of cancer, what is the role of microRNAs as epigenetic modifiers?
In the context of cancer, what is the role of microRNAs as epigenetic modifiers?
Which epigenetic modification involves the addition of a methyl group to DNA?
Which epigenetic modification involves the addition of a methyl group to DNA?
Flashcards
Epigenetic modifications
Epigenetic modifications
Changes to gene expression without altering DNA sequence, including methylation and histone modifications.
DNA methylation
DNA methylation
The addition of methyl groups to DNA, affecting gene expression and often silencing genes.
Histone modifications
Histone modifications
Chemical alterations to histone proteins that affect how tightly DNA is wound around them, influencing gene access.
MicroRNAs
MicroRNAs
Signup and view all the flashcards
Nucleosome remodelling
Nucleosome remodelling
Signup and view all the flashcards
Study Notes
Epigenetic Modifications in Cancer
- Epigenetic modifications (DNA methylation, histone modifications, microRNAs, and nucleosome remodeling) control gene expression in human cancers.
- Aberrant metabolism and biochemical pathways link genetics and epigenetics in cancer.
- Mutations in genes involved in epigenetic regulation contribute to cancer development.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
