Podcast
Questions and Answers
What may lead to T-helper type 2 (Th2) cell polarization in lichen nitidus?
What may lead to T-helper type 2 (Th2) cell polarization in lichen nitidus?
- Functioning cellular immunity
- Cytokine milieu produced by the inflammatory infiltrate (correct)
- Topical application of dinitrochlorobenzene
- Genetic factors
Which conditions have been associated with lichen nitidus?
Which conditions have been associated with lichen nitidus?
- Vitiligo, alopecia areata, and urticaria
- Psoriasis, eczema, and rosacea
- Atopic dermatitis, Crohn disease, and juvenile chronic arthritis (correct)
- Seborrheic dermatitis, acne, and molluscum contagiosum
What has been reported about the genetic factors of lichen nitidus?
What has been reported about the genetic factors of lichen nitidus?
- Multiple genetic variants contributing to the disease
- No genetic factors of the disease have been identified (correct)
- Inheritance pattern following Mendelian genetics
- Strong genetic linkage to specific alleles
What is the current understanding of the epidemiology of lichen nitidus?
What is the current understanding of the epidemiology of lichen nitidus?
How is lichen nitidus currently regarded in terms of its pathophysiology?
How is lichen nitidus currently regarded in terms of its pathophysiology?
What theory supports the formation of discrete inflammatory papules in lichen nitidus?
What theory supports the formation of discrete inflammatory papules in lichen nitidus?
How do most clinicians and researchers view the relationship between lichen nitidus and lichen planus?
How do most clinicians and researchers view the relationship between lichen nitidus and lichen planus?
What is the role of Langerhans cells in the pathophysiology of lichen nitidus?
What is the role of Langerhans cells in the pathophysiology of lichen nitidus?
Where are the most frequent sites of predilection for lichen nitidus?
Where are the most frequent sites of predilection for lichen nitidus?
What distinguishes palmar lichen nitidus from lichen planus?
What distinguishes palmar lichen nitidus from lichen planus?
Which phenomenon is observed in approximately 12% of cases of generalized lichen nitidus?
Which phenomenon is observed in approximately 12% of cases of generalized lichen nitidus?
What is a potential site of involvement that is less common for lichen nitidus?
What is a potential site of involvement that is less common for lichen nitidus?
In which age group is palmoplantar involvement more common?
In which age group is palmoplantar involvement more common?
What is a common location for hemorrhagic-purpuric lesions in actinic lichen nitidus?
What is a common location for hemorrhagic-purpuric lesions in actinic lichen nitidus?
In which individuals does actinic lichen nitidus appear most commonly?
In which individuals does actinic lichen nitidus appear most commonly?
What is a distinguishing feature of actinic lichen nitidus compared to other frictional lichenoid eruptions?
What is a distinguishing feature of actinic lichen nitidus compared to other frictional lichenoid eruptions?
What is the usual symptom presentation of lichen nitidus?
What is the usual symptom presentation of lichen nitidus?
What is the classic histologic pattern seen in 90% of lichen nitidus cases?
What is the classic histologic pattern seen in 90% of lichen nitidus cases?
What is the role of Langerhans cells in the majority of lichen nitidus cases?
What is the role of Langerhans cells in the majority of lichen nitidus cases?
What distinguishes actinic lichen nitidus from other frictional lichenoid eruptions?
What distinguishes actinic lichen nitidus from other frictional lichenoid eruptions?
What is a rare feature observed in about 10% of lichen nitidus cases?
What is a rare feature observed in about 10% of lichen nitidus cases?
Where are predilection sites for hemorrhagic-purpuric lesions in actinic lichen nitidus?
Where are predilection sites for hemorrhagic-purpuric lesions in actinic lichen nitidus?
What is a distinguishing feature of palmar lichen nitidus compared to lichen planus?
What is a distinguishing feature of palmar lichen nitidus compared to lichen planus?
What is the typical duration of lichen nitidus in two thirds of patients?
What is the typical duration of lichen nitidus in two thirds of patients?
Which of the following is a first-line treatment for lichen nitidus on the body?
Which of the following is a first-line treatment for lichen nitidus on the body?
What type of lesions develop as older lesions of lichen nitidus resolve?
What type of lesions develop as older lesions of lichen nitidus resolve?
For which subtype of lichen nitidus is acitretin a potential therapy?
For which subtype of lichen nitidus is acitretin a potential therapy?
What is the first-line systemic agent for pruritus in lichen nitidus?
What is the first-line systemic agent for pruritus in lichen nitidus?
Which medication has largely supplanted PUVA for generalized lichen nitidus?
Which medication has largely supplanted PUVA for generalized lichen nitidus?
What should be considered when deciding on systemic treatments for lichen nitidus?
What should be considered when deciding on systemic treatments for lichen nitidus?
What type of disease warrants treatment in lichen nitidus?
What type of disease warrants treatment in lichen nitidus?
Which therapy is most successful when combined with skin-directed therapies such as topical steroids or phototherapy?
Which therapy is most successful when combined with skin-directed therapies such as topical steroids or phototherapy?
What is a rarely indicated systemic treatment for lichen nitidus?
What is a rarely indicated systemic treatment for lichen nitidus?
Which condition may lead to T-helper type 2 (Th2) cell polarization in lichen nitidus?
Which condition may lead to T-helper type 2 (Th2) cell polarization in lichen nitidus?
What has been reported about the genetic factors of lichen nitidus?
What has been reported about the genetic factors of lichen nitidus?
What is the classic histologic pattern seen in 90% of lichen nitidus cases?
What is the classic histologic pattern seen in 90% of lichen nitidus cases?
Which cells predominate in the infiltrate of lichen nitidus cases?
Which cells predominate in the infiltrate of lichen nitidus cases?
What may be seen with clinical variants of lichen nitidus, such as palmar lesions?
What may be seen with clinical variants of lichen nitidus, such as palmar lesions?
In actinic lichen nitidus, where are purpuric or hemorrhagic lesions associated with capillary wall degeneration and red blood cell extravasation most likely to occur?
In actinic lichen nitidus, where are purpuric or hemorrhagic lesions associated with capillary wall degeneration and red blood cell extravasation most likely to occur?
What type of cells have been reported to predominate in the infiltrate of lichen nitidus?
What type of cells have been reported to predominate in the infiltrate of lichen nitidus?
Which features may be rarely observed in lichen nitidus cases?
Which features may be rarely observed in lichen nitidus cases?
What is the typical duration of lichen nitidus in two thirds of patients?
What is the typical duration of lichen nitidus in two thirds of patients?
What is the first-line topical treatment for lichen nitidus?
What is the first-line topical treatment for lichen nitidus?
What is the first-line systemic agent for pruritus in lichen nitidus?
What is the first-line systemic agent for pruritus in lichen nitidus?
Which systemic therapy is rarely indicated in lichen nitidus and should be reserved for more symptomatic and cosmetically disfiguring disease?
Which systemic therapy is rarely indicated in lichen nitidus and should be reserved for more symptomatic and cosmetically disfiguring disease?
What medication may hasten resolution of more extensive, generalized, or symptomatic lichen nitidus?
What medication may hasten resolution of more extensive, generalized, or symptomatic lichen nitidus?
Which therapy has largely supplanted PUVA for generalized lichen nitidus?
Which therapy has largely supplanted PUVA for generalized lichen nitidus?
For which subtype of lichen nitidus is acitretin a potential therapy?
For which subtype of lichen nitidus is acitretin a potential therapy?
What is a distinguishing feature of palmar lichen nitidus compared to lichen planus?
What is a distinguishing feature of palmar lichen nitidus compared to lichen planus?
What is a potential site of involvement that is less common for lichen nitidus?
What is a potential site of involvement that is less common for lichen nitidus?
What should be considered when deciding on systemic treatments for lichen nitidus?
What should be considered when deciding on systemic treatments for lichen nitidus?
What is the role of Langerhans cells in the majority of lichen nitidus cases?
What is the role of Langerhans cells in the majority of lichen nitidus cases?
What cells predominate in the infiltrate of lichen nitidus cases?
What cells predominate in the infiltrate of lichen nitidus cases?
In lichen nitidus, what is the distinguishing feature of palmar lesions?
In lichen nitidus, what is the distinguishing feature of palmar lesions?
Which type of lesions are associated with capillary wall degeneration and red blood cell extravasation in lichen nitidus?
Which type of lesions are associated with capillary wall degeneration and red blood cell extravasation in lichen nitidus?
What is the classic histologic pattern seen in 90% of lichen nitidus cases?
What is the classic histologic pattern seen in 90% of lichen nitidus cases?
What is rarely seen in lichen nitidus cases, with only about 10% of cases showing this feature?
What is rarely seen in lichen nitidus cases, with only about 10% of cases showing this feature?
Where do perforating lesions tend to occur in lichen nitidus?
Where do perforating lesions tend to occur in lichen nitidus?
What is the typical duration of lichen nitidus in two thirds of patients?
What is the typical duration of lichen nitidus in two thirds of patients?
What is the first-line topical treatment for lichen nitidus?
What is the first-line topical treatment for lichen nitidus?
Which therapy has largely supplanted PUVA for generalized lichen nitidus?
Which therapy has largely supplanted PUVA for generalized lichen nitidus?
Which systemic therapy is rarely indicated in lichen nitidus and should be reserved for more symptomatic and cosmetically disfiguring disease?
Which systemic therapy is rarely indicated in lichen nitidus and should be reserved for more symptomatic and cosmetically disfiguring disease?
What type of cells have been reported to predominate in the infiltrate of lichen nitidus cases?
What type of cells have been reported to predominate in the infiltrate of lichen nitidus cases?
What type of disease warrants treatment in lichen nitidus?
What type of disease warrants treatment in lichen nitidus?
