EORTC Consensus on Mycosis Fungoides Treatment 2023

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Questions and Answers

Which institution is associated with the Karl Landsteiner Institute of Dermatological Research?

Karl Landsteiner University of Health Sciences (correct)

INSERM U976

University of Applied Sciences Hamburg

University Hospital of Vienna

What is the primary focus of the reviewed consensus recommendations in the European Journal of Cancer?

Cancer prevention strategies

Therapy for mycosis fungoides/Sézary syndrome (correct)

Treatment of solid tumors

Management of infectious diseases

Which country is associated with the Department of Dermatology and Allergology at Kantonspital St.Gallen?

Switzerland (correct)

Germany

France

Austria

What type of specialist would most likely be involved in the treatment recommendations discussed in the article?

Dermatologist Signup and view all the answers

Which research institution is mentioned alongside the Department of Dermatology, HELIOS Klinikum Krefeld?

Medical School Hamburg Signup and view all the answers

What is the primary focus of skin-directed therapies in the treatment of mycosis fungoides (MF)?

They are most appropriate for early-stage MF. Signup and view all the answers

What is indicated about the prognosis for most patients with advanced disease in MF?

Prognosis remains poor with limited options. Signup and view all the answers

What does the current TNMB staging classification help to assess?

The cancer spread and treatment adequacy. Signup and view all the answers

Which option describes the outcome of allogeneic stem cell transplantation for selected patients with MF?

It can lead to long-term remission for some patients. Signup and view all the answers

What was the purpose of the workshop organized by the European Organisation of Research and Treatment of Cancer in 2004?

To develop a European consensus on treatment for MF and SS. Signup and view all the answers

What does the gradual advancement in understanding mycosis fungoides and its management indicate?

There is potential for ongoing improvement in patient care. Signup and view all the answers

What is a potential effect on the quality of life for patients early in the course of MF?

Patients may suffer morbidity and impaired quality of life. Signup and view all the answers

What is a significant characteristic of treatment options for advanced mycosis fungoides?

They often consist of multiple consecutive therapies. Signup and view all the answers

What was the primary intention of treatment in localized early stages of MF/SS?

To cure the disease Signup and view all the answers

Which treatment modality represents a significant exception to the general principle of palliative therapy in MF/SS?

Allogeneic stem cell transplantation (alloSCT) Signup and view all the answers

The classification of cutaneous T-cell lymphomas (CTCL) was most recently refined by which edition of the WHO classification?

5th edition Signup and view all the answers

What is the overall aim of the EORTC-consensus recommendations regarding treatment strategies for MF/SS?

To maintain quality of life Signup and view all the answers

What was a key update in the latest consensus for MF/SS treatment recommendations?

Introduction of novel treatment modalities Signup and view all the answers

In revising the EORTC-consensus recommendations, what approach was maintained?

Step-wise, stage-adapted approach Signup and view all the answers

Which aspect of treatment for MF/SS remains particularly rare, complicating guideline development?

Evidence from large randomized controlled trials Signup and view all the answers

How are the recommendations designed in relation to the previous version of the EORTC-consensus?

To avoid redundancy and duplication Signup and view all the answers

Which treatment option was added to the updated standard for mycosis fungoides and Sézary syndrome after 2017?

Chlormethine Signup and view all the answers

What type of therapy is associated with total skin electron beam treatment?

Radiotherapy Signup and view all the answers

Which of the following is not listed as a treatment option for cutaneous T-cell lymphomas?

Bone marrow transplant Signup and view all the answers

What is one of the key aspects related to the new recommendations for treatment in older patients?

Specifically tailored supportive therapy Signup and view all the answers

Which treatment is recommended after the withdrawal of recombinant unpegylated interferons?

Pegylated interferon α Signup and view all the answers

What mechanism was used to establish consensus among authors on the treatment standards?

A series of consultations in writing and discussions Signup and view all the answers

Which of the following is an example of a first-line treatment option according to the new standards?

Brentuximab vedotin Signup and view all the answers

Which drug is specifically mentioned as undergoing incorporation into clinical practice for MF/SS?

Mogamulizumab Signup and view all the answers

Which hospital is affiliated with the University of Alberta in Canada?

Division of Dermatology, Department of Medicine Signup and view all the answers

Which of the following locations is associated with the Medical University of Vienna?

Department of Dermatology, Medical University of Vienna Signup and view all the answers

Which university in Denmark has a dermatology department mentioned in the list?

University of Copenhagen Signup and view all the answers

Where is the University Department of Dermatology, Venereology, Allergology and Phlebology located?

Bochum, Germany Signup and view all the answers

Which trust is associated with Guy’s Hospital in London?

Guy's and St Thomas' NHS Foundation Trust Signup and view all the answers

Which country is home to the Department of Dermatology at the University of Florence?

Italy Signup and view all the answers

Which hospital is directly associated with the University Complutense?

Hospital Universitario 12 de Octubre Signup and view all the answers

What type of medical specialty is the Cutaneous Lymphoma Unit associated with?

Dermatology Signup and view all the answers

Study Notes

EORTC Consensus Recommendations Overview

Updated standards for treating mycosis fungoides (MF) and Sézary syndrome (SS) presented in 2023, following previous versions in 2006 and 2017.
Comprehensive review of recent literature and treatment options introduced after 2017.

Treatment Strategies

Treatment options categorized based on disease stage, with first- and second-line options annotated with levels of evidence.
Emphasis on skin-directed therapies for early-stage MF, providing patients with a normal life expectancy but potential morbidity.

New Treatment Options

Inclusion of chlormethine, brentuximab vedotin, and mogamulizumab as new treatments.
Recommendations on pegylated interferon α following withdrawal of unpegylated interferons.
Added sections on supportive therapy and care for older patients.

Advanced Disease Management

Treatment options for advanced disease have significantly expanded, though prognosis remains poor for many patients.
Long-term remission possible primarily through allogeneic stem cell transplantation (alloSCT) in select cases.

Clinical Context

Disease classification updated according to the WHO-EORTC classification for cutaneous lymphomas published in 2019.
Recommendations structured to assist in clinical decision-making while prioritizing quality of life.

Palliative Nature of Treatment

Current therapeutic approaches are generally palliative, focusing on improving patients' quality of life.
Advanced disease may still allow for significant interventions, though the treatment is mainly aimed at symptom management.

Consideration of Recent Advances

Advancements in understanding epidemiology, clinical course, and management strategies for MF/SS indicate potential improvements in patient care.
Existing guidelines developed by various national and international groups continue to aid in treatment decision-making.

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Description

Explore the updated EORTC consensus recommendations for treating mycosis fungoides and Sézary syndrome as presented in 2023. This quiz reviews new treatment options, strategies for different disease stages, and includes insights on supportive therapy for older patients. Test your knowledge on the evolving standards of care in this area.