Enzymes in Medical Biochemistry Quiz
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Enzymes can be grouped by function and form, similar to how tools are categorized based on their function and structure. This comparison is used to illustrate:

  • The unfamiliarity of certain enzymes and their potential functions.
  • The broad characterization of enzymes based on the reactions they catalyze and the chemistry they conduct. (correct)
  • The necessity of a wide range of enzymes to perform different biochemical tasks.
  • The specificities and exceptions in enzyme categorization.

    • In the context of the analogy between enzymes and tools, the 'giant wrench' represents:

  • An enzyme with a well-known function but unusual structure.
  • An enzyme with a typical structure and function.
  • A commonly used enzyme with a unique catalytic activity.
  • An unfamiliar enzyme with a potential function based on its structure. (correct)

    • The comparison between tools and enzymes emphasizes the need for:

  • A standardized set of enzymes for specific biochemical reactions.
  • Enzymes with similar structures but diverse functions.
  • A wide range of enzymes to accommodate different biochemical tasks. (correct)
  • Enzymes with diverse structures but similar functions.

    • The analogy between tools and enzymes highlights the importance of categorizing enzymes based on:

    <p>Their function and the reactions they catalyze.</p> Signup and view all the answers

    Which of the following is a potential outcome of understanding enzyme properties?

    <p>Identification of different types of inhibitors</p> Signup and view all the answers

    What can knowledge of enzyme structure help determine?

    <p>Possible reaction mechanisms</p> Signup and view all the answers

    What do thermodynamic parameters such as free energy and entropy not reveal?

    <p>The speed or rate of a reaction</p> Signup and view all the answers

    What is the primary function of enzymes in biological systems?

    <p>Increase the rates of reactions</p> Signup and view all the answers

    What can mutations to DNA sequences potentially alter?

    <p>Enzyme function</p> Signup and view all the answers

    What provides important biochemical information for elucidating enzymatic mechanisms?

    <p>The structure of an enzyme and the position of amino acid side chains in the active site</p> Signup and view all the answers

    What is the role of many enzymes in transmitting and carrying out biochemical signals in the cell?

    <p>Play important roles in transmitting and carrying out biochemical signals</p> Signup and view all the answers

    What do most biochemical reactions rely on for catalysis?

    <p>Enzymes</p> Signup and view all the answers

    What is the primary characteristic of enzymes in biological systems?

    <p>Protein catalysts</p> Signup and view all the answers

    What contributes to increasing the rates of reactions in biological systems to the point where they can be used at room temperature?

    <p>Catalysts in biological systems</p> Signup and view all the answers

    What are enzymes usually in terms of their protein structure?

    <p>Globular proteins</p> Signup and view all the answers

    What do enzymes contribute to in biological systems?

    <p>Increasing the rates of reactions</p> Signup and view all the answers

    Which model describes the interaction of the substrate with the enzyme?

    <p>Lock and key model</p> Signup and view all the answers

    What percentage of reactions involve more than one substrate and have more than one product?

    <p>Over 60%</p> Signup and view all the answers

    Where does catalysis occur in an enzyme?

    <p>Active site</p> Signup and view all the answers

    What is responsible for substrate binding and catalysis on the active site surface of enzymes?

    <p>Residues</p> Signup and view all the answers

    How are enzymatic reactions categorized based on the type of substrate and the mechanism of action of the enzyme involved?

    <p>Into six classes</p> Signup and view all the answers

    Which class of enzymatic reactions involves the transfer of functional groups between substrates?

    <p>Transferases</p> Signup and view all the answers

    What are examples of subclasses within the oxidoreductases class?

    <p>Oxidases and peroxidases</p> Signup and view all the answers

    Which type of enzyme has multiple catalytic subunits that interact and regulate each other?

    <p>Multimeric enzymes</p> Signup and view all the answers

    What is the term for the molecules produced in enzymatically catalyzed reactions?

    <p>Products</p> Signup and view all the answers

    Where is the active site usually located on an enzyme?

    <p>In a cleft, pocket, or trench on the enzyme's surface</p> Signup and view all the answers

    What is the term for enzymes with two or more subunits?

    <p>Multimeric enzymes</p> Signup and view all the answers

    What is the term for the reactants in enzymatically catalyzed reactions?

    <p>Substrates</p> Signup and view all the answers

    What is the function of enzymes in catalyzing reactions?

    <p>Increasing rates of reaction by lowering activation energy</p> Signup and view all the answers

    How is the active site of an enzyme characterized?

    <p>Specific and tight binding of the substrate</p> Signup and view all the answers

    What is the relationship between enzymes and equilibrium of a reaction?

    <p>Enzymes do not alter equilibrium but allow systems to achieve equilibrium more quickly</p> Signup and view all the answers

    How are rates of enzymatically catalyzed reactions derived?

    <p>From rates of chemical reactions</p> Signup and view all the answers

    What defines the rate of a chemical reaction?

    <p>The change in concentration of a reactant or product over time</p> Signup and view all the answers

    How can enzymatically catalyzed reactions be categorized?

    <p>Based on the type of reaction they catalyze</p> Signup and view all the answers

    What determines the rate of a chemical reaction?

    <p>The concentration of the reactant and product</p> Signup and view all the answers

    What is the integrated rate law used for?

    <p>Expressing product concentration as a function of time</p> Signup and view all the answers

    What does the rate constant (k) relate to?

    <p>The concentration to the rate of the reaction</p> Signup and view all the answers

    What does the frequency factor (A) describe?

    <p>The percentage of collisions resulting in a favorable reaction</p> Signup and view all the answers

    How do enzymes increase the rate of a reaction?

    <p>By lowering the activation energy barrier and stabilizing the transition state through specific binding of the substrate to the active site</p> Signup and view all the answers

    What is the main characteristic of enzymes as protein catalysts?

    <p>They increase rates of reaction by lowering activation energy</p> Signup and view all the answers

    Which enzyme is classified as a phosphorus-oxygen lyase that acts on ATP?

    <p>Adenylate cyclase</p> Signup and view all the answers

    Which of the following enzymes is typically found in the liver or muscle, and indicates organ damage if elevated in blood?

    <p>Lactate dehydrogenase (LDH)</p> Signup and view all the answers

    What is the primary function of enzymes in biological systems?

    <p>Lower activation energy of reactions</p> Signup and view all the answers

    What change in activation energy results in an astounding 106-fold change in the rate constant (k) at the same temperature?

    <p>10 kJ/mol</p> Signup and view all the answers

    How do enzymes facilitate reactions?

    <p>By forming a pocket to bring groups together or pull them apart</p> Signup and view all the answers

    What do elevated levels of LDH, ALT, AST, and CPK in blood indicate?

    <p>Tissue or organ damage</p> Signup and view all the answers

    How are enzymes classified by the Enzyme Commission (EC)?

    <p>By their category and unique EC number</p> Signup and view all the answers

    What do enzymes do as catalysts without changing thermodynamic parameters or affecting equilibrium?

    <p>Lower activation energy</p> Signup and view all the answers

    What is the primary role of enzymes in blood used for medical diagnosis?

    <p>Identifying tissue or organ damage</p> Signup and view all the answers

    How do enzymes increase reaction rates?

    <p>By lowering activation energy</p> Signup and view all the answers

    What is the main characteristic of enzymes as protein catalysts?

    <p>Lowering activation energy</p> Signup and view all the answers

    What is the function of enzymes as catalysts in biological systems?

    <p>Lower activation energy of reactions</p> Signup and view all the answers

    Study Notes

    Enzymatically Catalyzed Reaction and Chemical Rates

    • Lysozyme is an enzyme that catalyzes the hydrolytic cleavage of carbohydrate chains in bacterial cell walls, belonging to EC classification 3, hydrolases.
    • Enzymes are protein catalysts that increase rates of reaction by lowering activation energy, often being monomeric or multimeric globular proteins.
    • The active site of an enzyme specifically binds the substrate, and the binding is specific and tight, excluding solvent.
    • Enzymes can be categorized based on the type of reaction they catalyze, and they do not alter equilibrium but allow systems to achieve equilibrium more quickly.
    • Rates of enzymatically catalyzed reactions can be derived from rates of chemical reactions and are powerful tools for describing reactions.
    • The rate of a chemical reaction is defined as the change in concentration of a reactant or product over time.
    • Enzymatically catalyzed reactions can be categorized based on the six types of reactions found in section 4.1.2.
    • The rate of a chemical reaction is determined by the concentration of the reactant and product, and can vary linearly, quadratically, or independently.
    • The integrated rate law for first, second, and zeroth-order reactions allows expressing product concentration as a function of time.
    • The rate constant (k) relates the concentration to the rate and has a frequency factor (A) and an exponential term that relates the activation energy (Ea), the temperature (T), and the gas law constant (R).
    • The frequency factor (A) describes the percentage of collisions that result in a favorable reaction, and the exponential term relates the activation energy, temperature, and gas law constant.
    • Enzymes increase the rate of a reaction by lowering the activation energy barrier and stabilizing the transition state through specific binding of the substrate to the active site.

    Enzyme Classification and Function in Medical Biochemistry

    • Enzymes are classified into 6 major groups by the Enzyme Commission (EC) of the International Union of Biochemistry and Molecular Biology (IUBMB), with each enzyme having a unique EC number.
    • Adenylate cyclase is an example of an enzyme classified as a lyase (Class 4) and further subclassified as a phosphorus-oxygen lyase that acts on ATP.
    • Enzyme activity in blood is used in medical diagnosis, with a comprehensive metabolic panel including measurements of enzymes not typically found in blood, indicating organ damage if present.
    • Lactate dehydrogenase (LDH), alanine transaminase (ALT), aspartate aminotransferase (AST), and creatine phosphokinase (CPK) are enzymes found in the liver or muscle, and their elevated levels in blood indicate damage to these organs.
    • Enzymes work as catalysts by lowering the activation energy of a reaction without changing the thermodynamic parameters or affecting equilibrium.
    • Catalysts increase reaction rate by lowering the energy of the transition state, which is limited by the height of the activation energy.
    • Enzymes lower activation energy by forming a pocket that brings groups together or pulls them apart to form a structure similar to the transition state, promoting electron flow and constraining molecules.
    • A 36 kJ/mol change in activation energy results in an astounding 106-fold change in the rate constant (k) at the same temperature.
    • Enzymes facilitate reactions by binding substrates using weak forces and steric interactions to align functional groups, polarize bonds, and promote electron flow to favorably orient molecules for reactions to occur.
    • Enzyme activity in blood is utilized for diagnosis, with LDH, ALT, AST, and CPK serving as markers for tissue or organ damage.
    • Enzymes are classified into 6 major groups, with each enzyme having a unique EC number based on its category and further subclassifications by the Enzyme Commission (EC).
    • Enzymes work as catalysts by lowering the activation energy of a reaction without changing the thermodynamic parameters or affecting equilibrium, facilitating the reaction by forming a pocket that brings groups together or pulls them apart to form a structure similar to the transition state.

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    Enzyme Biochemistry PDF

    Description

    Test your knowledge of enzymatically catalyzed reactions, enzyme classification, and the function of enzymes in medical biochemistry with this quiz. Explore topics such as enzyme commission classification, enzyme catalysis, reaction rates, and enzyme activity in medical diagnosis.

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