Enzyme Inhibition and Cofactors

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6 Questions

What is the primary mechanism by which competitive inhibitors reduce the efficiency of an enzyme?

By competing with the substrate for the active site

What is the role of cofactors in enzyme catalysis?

To function in some crucial way to allow catalysis to occur

What is the effect of an increase in cell volume on its surface area?

The surface area decreases

What is the direction of proton movement during proton pump cotransport?

Out of the cell, driven by active transport

What is the characteristic of noncompetitive inhibitors?

They bind to another part of the enzyme and change its shape

What is the purpose of proton pump cotransport in cells?

To transport molecules across the cell membrane

Study Notes

Inhibition of Enzymes

  • Competitive inhibition occurs when reversible inhibitors, which are chemically similar to the normal substrate molecule, compete with the substrate for the active site on an enzyme, reducing its efficiency.

Types of Inhibition

  • Noncompetitive inhibition: occurs when inhibitors bind to another part of the enzyme, causing a shape change that makes the active site nonfunctional, impeding enzyme activity.

Cofactors

  • Cofactors are non-protein helpers, including metal ions like zinc, iron, and copper, which function in a crucial way to allow catalysis to occur, serving as enzyme helpers.

Cell Characteristics

  • As cell volume increases, the surface area decreases, which is why cells are typically small.

Proton Pump Cotransport

  • Proton pump cotransport is a type of transport that uses H+ ions and occurs in various cellular processes.
  • H+ ions are involved in active transport, moving from an area of high concentration to an area of low concentration (in or out).
  • In cotransport, H+ ions come in (passive transport) and are associated with cotransport mechanisms.

Learn about the different types of enzyme inhibition, including competitive and noncompetitive inhibition, and the role of cofactors in enzyme activity.

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