Podcast
Questions and Answers
Which process is responsible for much of the hypermetabolism seen in cancer cachexia?
Which process is responsible for much of the hypermetabolism seen in cancer cachexia?
- Gluconeogenesis (correct)
- Pyruvate reduction
- Glycolysis
- Lactate export
What is the main implication for cancer therapy due to the acidic local environment formed in tumors?
What is the main implication for cancer therapy due to the acidic local environment formed in tumors?
- Lactate export inhibition
- Enhanced pyruvate production
- Increased glycolysis rate
- Altered drug effectiveness (correct)
In which cells does glycolysis proceed at a high rate, forming large amounts of pyruvate?
In which cells does glycolysis proceed at a high rate, forming large amounts of pyruvate?
- Mature red blood cells
- Healthy hepatocytes
- Fast-growing cancer cells (correct)
- Resting muscle cells
What condition can result from impaired activity of pyruvate dehydrogenase?
What condition can result from impaired activity of pyruvate dehydrogenase?
Which enzyme deficiency is mainly associated with hemolytic anemias?
Which enzyme deficiency is mainly associated with hemolytic anemias?
What is the primary consequence of deficient pyruvate kinase in skeletal muscle?
What is the primary consequence of deficient pyruvate kinase in skeletal muscle?
How does glycolysis in fast-growing cancer cells impact the local tumor environment?
How does glycolysis in fast-growing cancer cells impact the local tumor environment?
What is the energy-expensive process that uses lactate for glucose production?
What is the energy-expensive process that uses lactate for glucose production?
Which condition can result from impaired pyruvate dehydrogenase activity?
Which condition can result from impaired pyruvate dehydrogenase activity?
What is the main implication of the acidic tumor environment for cancer therapy?
What is the main implication of the acidic tumor environment for cancer therapy?
