10 Questions
Which process is responsible for much of the hypermetabolism seen in cancer cachexia?
Gluconeogenesis
What is the main implication for cancer therapy due to the acidic local environment formed in tumors?
Altered drug effectiveness
In which cells does glycolysis proceed at a high rate, forming large amounts of pyruvate?
Fast-growing cancer cells
What condition can result from impaired activity of pyruvate dehydrogenase?
Lactic acidosis
Which enzyme deficiency is mainly associated with hemolytic anemias?
Pyruvate kinase
What is the primary consequence of deficient pyruvate kinase in skeletal muscle?
Fatigue
How does glycolysis in fast-growing cancer cells impact the local tumor environment?
Creates a relatively acidic environment
What is the energy-expensive process that uses lactate for glucose production?
Gluconeogenesis
Which condition can result from impaired pyruvate dehydrogenase activity?
Lactic acidosis
What is the main implication of the acidic tumor environment for cancer therapy?
Resistance to chemotherapy
Explore the impact of enzyme deficiencies in glycolysis on hemolytic anemias, fatigue in skeletal muscle, and the high rate of glycolysis in fast-growing cancer cells. Understand the production of lactate and its implications for cancer therapy.
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