Enzyme Activators and Inhibitors Quiz
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Questions and Answers

Which of the following molecules acts as an inhibitor for Hexokinase?

  • Fructose-6-phosphate
  • AMP
  • ADP
  • Glucose-6-phosphate (correct)

What is the effect of Fructose-2,6-bisphosphate on PFK-1?

  • It converts the enzyme into an inactive form
  • It activates the enzyme (correct)
  • It inhibits the enzyme
  • It has no effect on the enzyme

Which of the following compounds would likely reduce the activity of Pyruvate kinase?

  • NADH
  • Fructose-1,6-bisphosphate
  • ATP (correct)
  • AMP

Which of the following is NOT an activator of Hexokinase?

<p>Fructose-6-phosphate (A)</p> Signup and view all the answers

Which pair correctly matches an enzyme with its activators?

<p>Pyruvate kinase: Fructose-1,6-bisphosphate, AMP (B)</p> Signup and view all the answers

Which compound listed acts as an activator for Pyruvate kinase?

<p>Fructose-1,6-bisphosphate (A)</p> Signup and view all the answers

What is a common inhibitor of PFK-1?

<p>NADH (C)</p> Signup and view all the answers

Which statement about Hexokinase is true?

<p>It is activated by AMP. (D)</p> Signup and view all the answers

Which of the following activators stimulates PFK-1 the most effectively?

<p>Fructose-2,6-bisphosphate (D)</p> Signup and view all the answers

Identify the molecule that acts as an inhibitor for Pyruvate kinase.

<p>Acetyl-CoA (C)</p> Signup and view all the answers

Flashcards

Hexokinase activator

AMP, ADP, inorganic phosphate ($P_i$), and fructose-6-phosphate activate hexokinase.

Hexokinase inhibitor

Glucose-6-phosphate inhibits hexokinase.

PFK-1 activator

Fructose-2,6-bisphosphate activates phosphofructokinase-1 (PFK-1).

PFK-1 inhibitor

NADH, citrate and ATP inhibits phosphofructokinase-1 (PFK-1).

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Pyruvate kinase inhibitor

ATP and Acetyl-CoA inhibit pyruvate kinase.

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Hexokinase activator

AMP, ADP, inorganic phosphate (Pi), and fructose-6-phosphate activate hexokinase.

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PFK-1 activator

Fructose-2,6-bisphosphate activates phosphofructokinase-1 (PFK-1).

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PFK-1 inhibitor

NADH, citrate, and ATP inhibit phosphofructokinase-1 (PFK-1).

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Pyruvate kinase activator?

AMP and Fructose-1,6-bisphosphate activate pyruvate kinase.

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Pyruvate kinase inhibitor?

ATP and Acetyl-CoA inhibit pyruvate kinase.

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Study Notes

Enzyme Activators and Inhibitors

  • Hexokinase:

    • Activators: AMP, ADP, Pi
    • Inhibitor: Glucose-6-phosphate
  • PFK-1:

    • Activator: Fructose-2,6-bisphosphate
    • Inhibitors: NADH, Citrate, ATP
  • Pyruvate kinase:

    • Activators: AMP, Fructose-1,6-bisphosphate
    • Inhibitors: ATP, Acetyl-CoA

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Description

Test your knowledge on enzyme activators and inhibitors related to key enzymes like hexokinase, PFK-1, and pyruvate kinase. This quiz covers the roles of various molecules that stimulate or inhibit these enzymes, essential for understanding metabolic pathways.

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