Environmental Toxicants Overview
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Questions and Answers

Which statement accurately describes the difference between acute and chronic toxicity?

  • Acute toxicity results from prolonged exposure to a small dose.
  • Chronic toxicity has immediate health effects while acute does not.
  • Chronic toxicity is related to a single high exposure.
  • Acute toxicity is associated with a single exposure to a large dose. (correct)
  • What is a common outcome associated with the chronic exposure to aflatoxin B1?

  • Development of liver cancer. (correct)
  • Acute poisoning followed by rapid recovery.
  • Respiratory irritation from air pollutants.
  • Liver failure and immediate death.
  • Which of the following is considered an anthropogenic air pollutant?

  • Ozone
  • Volcanic ash
  • Automobile exhaust (correct)
  • Dust storms
  • What component of air pollution is categorized as particulate matter?

    <p>Lead particles</p> Signup and view all the answers

    What is the predominant health effect associated with air pollution?

    <p>Chemical irritation of the respiratory tract</p> Signup and view all the answers

    Which of the following substances is known to cause lung cancer?

    <p>Asbestos</p> Signup and view all the answers

    Which of the following cancers is strongly associated with the bacterium Helicobacter pylori?

    <p>Stomach Cancer</p> Signup and view all the answers

    What is a primary goal of cancer treatment focused on 'controlling' the disease?

    <p>Stopping the cancer from spreading</p> Signup and view all the answers

    Which of the following is NOT considered a method of cancer treatment?

    <p>Vaccine Therapy</p> Signup and view all the answers

    What is a significant environmental concern regarding the use of pharmaceuticals?

    <p>They are recognized as pollutants in surface water.</p> Signup and view all the answers

    How do antibiotics primarily enter groundwater and soils from agricultural use?

    <p>Through routine application in livestock</p> Signup and view all the answers

    Which of the following factors is NOT listed as a goal of cancer treatment?

    <p>Minimize healthcare costs</p> Signup and view all the answers

    Which type of cancer is linked to Hepatitis B and C infections?

    <p>Liver Cancer</p> Signup and view all the answers

    What unique characteristic of cancer cells allows them to spread throughout the body?

    <p>Ability to invade surrounding normal tissue</p> Signup and view all the answers

    Which factor is considered non-modifiable in the development of cancer?

    <p>Genetic makeup</p> Signup and view all the answers

    What is one reason anticancer drugs cannot use the minimum therapeutic dose as a standard for environmental risk?

    <p>They exhibit significant toxicities even at minimal doses.</p> Signup and view all the answers

    What lifestyle factor has been linked to increased risk for lung cancer?

    <p>Tobacco use</p> Signup and view all the answers

    Which of the following best describes the concentration of pharmaceuticals in the environment?

    <p>Influenced by sewage treatment efficacy</p> Signup and view all the answers

    What percentage of deaths in Canada are attributed to cancer?

    <p>30%</p> Signup and view all the answers

    In which demographic is cancer predominantly diagnosed?

    <p>Canadians 50 or older</p> Signup and view all the answers

    What dietary component has been strongly linked to colorectal and prostate cancers?

    <p>Saturated animal fat</p> Signup and view all the answers

    What percentage of unused drugs are typically disposed of by being flushed down the sink or toilet?

    <p>25%</p> Signup and view all the answers

    Which type of drugs has seen a 60% increase in usage over the past decade?

    <p>Neuroreactive drugs</p> Signup and view all the answers

    What is a major concern regarding steroid hormone compounds found in the environment?

    <p>Their deleterious effect on aquatic animal reproduction</p> Signup and view all the answers

    What is known about the effects of hypertensive drugs in surface waters?

    <p>They are present but at non-toxic levels</p> Signup and view all the answers

    What is a concern regarding the antibiotics used in aquaculture?

    <p>They promote rapid growth and can lead to high local concentrations</p> Signup and view all the answers

    What happens to a percentage of all pharmaceuticals consumed by humans?

    <p>They enter the environment as unchanged drugs or active metabolites</p> Signup and view all the answers

    Which class of drugs is notably linked to potentially causing negative effects on the reproductive and physiological development of fish in water bodies?

    <p>Selective serotonin reuptake inhibitors</p> Signup and view all the answers

    What is a significant environmental concern related to pharmaceutical discharges from manufacturing plants?

    <p>They can lead to long-term degradation of surface and groundwater</p> Signup and view all the answers

    What is the primary effect of organochloride insecticides on the nervous system?

    <p>It increases neuronal sensitivity leading to convulsions.</p> Signup and view all the answers

    What major problem led to the ban of DDT in the 1970s?

    <p>It resulted in resistance in insect populations.</p> Signup and view all the answers

    Which statement is true about organophosphorus insecticides?

    <p>They irreversibly inhibit acetylcholinesterase in humans.</p> Signup and view all the answers

    What health risk is associated with exposure to environmental tobacco smoke?

    <p>Similar health risks as direct smoking.</p> Signup and view all the answers

    What is a common characteristic of both insecticides and herbicides?

    <p>They intentionally kill living organisms.</p> Signup and view all the answers

    Why are organophosphorus insecticides considered highly toxic to humans?

    <p>They cause buildup of acetylcholine in the nervous system.</p> Signup and view all the answers

    What demographic is identified as being particularly susceptible to air pollution?

    <p>Certain subpopulations.</p> Signup and view all the answers

    What common outcome results from the absorption of organophosphorus insecticides through the skin?

    <p>Severe poisoning symptoms.</p> Signup and view all the answers

    Study Notes

    Environmental Toxicants

    • Environmental toxicants are chemicals released into the environment that cause adverse health effects in living organisms.
    • Acute toxicity is associated with a single exposure at a high dose.
    • Chronic toxicity is associated with repeated exposure at low doses over a long period.
    • Examples of environmental toxicants include aflatoxin B1 (common food contaminant) which causes liver failure/cancer.

    Common Environmental Toxicants

    • Air pollution is divided into particulate matter and gaseous pollutants.
    • Particulate matter is a mixture of tiny particles (liquid or solid). Sources can be natural (volcanoes, fires, dust) or man-made (combustion of fossil fuels, industrial processes, vehicle exhaust).
    • Gaseous air pollutants include carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides, ozone, etc.

    Pesticides

    • Insecticides and herbicides are environmental toxicants that kill insects or prevent plant growth, respectively.
    • Organochlorine insecticides (e.g., DDT) work by increasing neuron sensitivity, causing tremors, convulsions, and death.
    • Organophosphorus insecticides are generally unstable in the environment and break down quickly, with lower environmental impact than organochlorine insecticides.
    • Herbicides kill or harm plants.

    Cancer Statistics

    • Cancer primarily affects individuals aged 50 or older.
    • Approximately 45% of men and 43% of women will develop cancer.
    • Cancer is a leading cause of death in Canada, with approximately 30% of deaths attributed to this disease.
    • Lung cancer is the most common type of cancer.

    Cancer Cell Features

    • Cancer cells can grow and divide indefinitely.
    • They can invade surrounding normal tissue.
    • They can spread throughout the body (metastasis).

    Cancer Causes

    • Genetics (e.g., Xeroderma pigmentosum impacting DNA repair) play a role in individual cancer susceptibility.
    • Environmental factors (e.g., chemical exposure, diet, infection) also contribute.
    • Specific environmental factors like tobacco smoke (smoking and secondhand exposure) are associated with increased cancer risk (e.g., lung cancer).
    • Diet (dietary components) is a modifiable risk factor.

    Cancer Treatment Goals

    • Preventing cancer involves preventing cancer cell growth or removing precancerous cells.
    • Curing cancer is the main goal of certain treatments.
    • Controlling cancer growth and preventing the spread is another treatment goal.
    • Relieving symptoms is a necessary approach when curing is not possible.

    Toxic Effects of Specific Chemicals (Lead)

    • Lead is an ubiquitous,naturally occurring element in the environment and different compounds. Lead oxide and tetraethyl lead are toxic compounds.
    • Exposure happens through old paint (in the 1950s), where a brighter colour was achieved. Lead was also commonly used in batteries.

    Toxic Effects of Specific Chemicals (Mercury)

    • Mercury is found in water and air and is used in industries. Contamination sources are water and air.
    • Mercury in water is concentrated in the aquatic food chain.
    • Two toxic forms exist: mercuric mercury (inhaled or absorbed through skin) and methyl mercury (ingested). Methyl mercury is commonly more toxic to people.

    Toxic Effects of Specific Chemicals (Bisphenol A [BPA])

    • Bisphenol A (BPA) is an industrial chemical used to make polycarbonate plastics (e.g., water bottles, food containers), and it can leach into the environment.
    • BPA exposure can occur through diet and can increase with heating.

    Toxic Effects of Specific Chemicals (Pharmaceuticals)

    • Increased use of pharmaceuticals led to their recognition as environmental pollutants.
    • They are found in surface water, groundwater and soils (most studied in surface waters).
    • Pharmaceuticals can have adverse effects on aquatic species and birds, even at low concentrations;
    • Pharmaceuticals can have adverse effects on humans if exposed and absorbed at high concentrations.

    Chemotherapy

    • Chemotherapy is a drug treatment approach to kill cancer cells.
    • Chemotherapy drug classes include alkylating agents, mitotic inhibitors, hormones/hormone antagonists and biologicals.
    • Cancer chemotherapy commonly includes a combination of therapies.

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    Description

    This quiz covers the fundamentals of environmental toxicants, including their definitions, types, and examples. Learn about acute and chronic toxicity, the impact of air pollution, and the role of pesticides. Test your understanding of how these toxicants affect health and the environment.

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