Podcast
Questions and Answers
What is the definition of health?
What is the definition of health?
What is the definition of disease?
What is the definition of disease?
What factors contribute to morbidity and mortality?
What factors contribute to morbidity and mortality?
What is the term for combining premature deaths and loss of healthy life resulting from illness or disability?
What is the term for combining premature deaths and loss of healthy life resulting from illness or disability?
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What percentage of premature deaths and diseases are accounted for by chronic conditions?
What percentage of premature deaths and diseases are accounted for by chronic conditions?
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What is the predicted leading source of disability and disease worldwide by 2020?
What is the predicted leading source of disability and disease worldwide by 2020?
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What is the predicted increase in global cancer rates?
What is the predicted increase in global cancer rates?
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What percentage of children born in North America today will develop diabetes in their lifetime?
What percentage of children born in North America today will develop diabetes in their lifetime?
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What is the main focus of conservation medicine?
What is the main focus of conservation medicine?
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Why are pesticides becoming less effective?
Why are pesticides becoming less effective?
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What is a consequence of antibiotic overuse in agriculture?
What is a consequence of antibiotic overuse in agriculture?
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Why do some antibiotic doses prescribed in the US go to waste?
Why do some antibiotic doses prescribed in the US go to waste?
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What is a consequence of antibiotic resistance in hospitals?
What is a consequence of antibiotic resistance in hospitals?
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Where do most disease burdens occur?
Where do most disease burdens occur?
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What percentage of health care dollars are spent in developing countries?
What percentage of health care dollars are spent in developing countries?
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What is a threat to oak, redwoods, and Douglas fir trees in California?
What is a threat to oak, redwoods, and Douglas fir trees in California?
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What do mutagens damage or alter?
What do mutagens damage or alter?
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What is the leading cause of death in the U.S.?
What is the leading cause of death in the U.S.?
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What percentage of U.S. adults are considered overweight?
What percentage of U.S. adults are considered overweight?
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What determines the movement of a toxin?
What determines the movement of a toxin?
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What type of compounds move rapidly through the environment?
What type of compounds move rapidly through the environment?
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What is the primary route of exposure to toxins?
What is the primary route of exposure to toxins?
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Why are children more vulnerable to toxins?
Why are children more vulnerable to toxins?
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What is the consequence of fat soluble compounds in the body?
What is the consequence of fat soluble compounds in the body?
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What is the primary site of detoxification of both natural and introduced poisons in mammals?
What is the primary site of detoxification of both natural and introduced poisons in mammals?
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Why can irritating agents be potentially carcinogenic?
Why can irritating agents be potentially carcinogenic?
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What is the purpose of animal testing in measuring toxicity?
What is the purpose of animal testing in measuring toxicity?
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What is the term for the dose of a toxin that is lethal to 50% of an animal test population?
What is the term for the dose of a toxin that is lethal to 50% of an animal test population?
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Why are dose-response curves not symmetrical?
Why are dose-response curves not symmetrical?
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What is the amount of a moderate toxin required to produce a lethal dose?
What is the amount of a moderate toxin required to produce a lethal dose?
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Why is it difficult to estimate the risk of toxins to humans?
Why is it difficult to estimate the risk of toxins to humans?
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What is the purpose of excretion in reducing the effects of waste products and environmental toxins?
What is the purpose of excretion in reducing the effects of waste products and environmental toxins?
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What is a common mistake people make when evaluating their abilities?
What is a common mistake people make when evaluating their abilities?
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Why do people have an exaggerated fear of certain events?
Why do people have an exaggerated fear of certain events?
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What is the general rule for tolerating risk according to the text?
What is the general rule for tolerating risk according to the text?
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What is the acceptable risk of death from environmental hazards according to the EPA?
What is the acceptable risk of death from environmental hazards according to the EPA?
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When setting health policy, what should be considered?
When setting health policy, what should be considered?
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What is a key consideration when evaluating the risks of environmental contaminants?
What is a key consideration when evaluating the risks of environmental contaminants?
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Study Notes
Environmental Health
- Environmental health is a state of complete physical, mental, and social well-being
- Disease is an abnormal change in the body's condition that impairs physical or psychological function
- Factors contributing to morbidity (illness) and mortality (death) include diet and nutrition, infectious agents, toxic chemicals, genetics, trauma, and psychological stress
Global Disease Burden
- Life expectancy is increasing as infant mortality decreases
- Disability-adjusted life years (DALYs) combine premature deaths and loss of healthy life resulting from illness or disability
- Chronic conditions account for 60% of premature deaths and 50% of diseases
- By 2020, heart disease may become the leading source of disability and disease worldwide
- Global cancer rates will increase by 50%
Infectious and Emergent Diseases
- Diabetes is on the increase, with one-third of children born in North America today expected to develop diabetes in their lifetime due to poor diet and little exercise
- Conservation medicine examines how environmental changes threaten the health of humans and natural communities
- Examples of environmental health risks include:
- Herpes 1 virus spreading to California sea lions from human sewage
- An imported fungus killing oak, redwoods, and Douglas fir trees in California
- Dermo, a parasite of oysters, spreading rapidly along the east coast due to climate warming
Antibiotics and Pesticide Resistance
- The protozoan parasite that causes malaria is now resistant to most antibiotics, while the mosquitoes that transmit it have developed resistance to many insecticides
- Overuse of pesticides speeds up the process of pesticide resistance
- Antibiotics are routinely fed to U.S. farm animals to stimulate weight gain, which creates antibiotic resistance
- Antibiotic-resistant strains of MRSA are spreading through hospitals in the US and China, resulting in thousands of deaths
Toxicology
Movement, Distribution, and Fate of Toxins
- Solubility is one of the most important characteristics in determining the movement of a toxin
- Chemicals are divided into two major groups:
- Those that dissolve more readily in water
- Those that dissolve more readily in oil
- Water-soluble compounds move rapidly through the environment and have access to cells
- Fat-soluble compounds need a carrier to move through the environment, but once inside the body, they penetrate tissues easily and are stored in body fat, persisting for many years
Exposure and Susceptibility
- Airborne toxins generally cause more ill health than any other exposure
- The lining of the lungs easily absorbs toxins
- Food, water, and skin contact are other ways to be exposed to toxins
- The largest toxin exposure is reported in industrial settings
- The condition of the organism and the timing of exposure also have strong influences on toxicity
- Children are more vulnerable than adults
Minimizing Toxic Effects
- Every material can be poisonous under certain conditions
- Most chemicals have a safe threshold under which their effects are insignificant
- Metabolic degradation is a process by which the liver breaks down toxins
- Sometimes, compounds that are harmless can be broken down into products that are harmful
Excretion and Repair
- Effects of waste products and environmental toxins are reduced by eliminating via excretion (breathing, urine, etc.)
- Tissues and organs often have mechanisms for damage repair by cellular reproduction
- Any irritating agent can be potentially carcinogenic because the more times cells divide, the greater the chance of DNA mistakes (mutations) that can lead to cancer
Measuring Toxicity
- Animal testing is the most commonly used and widely accepted toxicity test
- Humanitarian concerns arise in using animals for testing
- Different individuals have different sensitivities to the same toxin
- Should we aim to protect the average person or the most sensitive?
Complications in Measuring Toxicity
- Unrelated species can react quite differently to the same toxin due to differences in physiology and metabolism
- Dose-response curves are not symmetrical
- LD50 (dose at which 50% of the animal test population dies) varies between species
- These variations make it difficult to estimate the risk to humans
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Description
This quiz covers environmental health and toxicology, including infectious and emergent diseases. It's based on a lecture outline by William P. Cunningham and Mary Ann Cunningham. Topics include environmental health, diseases, and toxicology.