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Questions and Answers
What is the MOA of entacapone?
What is the MOA of entacapone?
Inhibits COMT enzyme decreasing metabolism of levodopa in the intestines and peripheral tissue.
What type of drug is entacapone?
What type of drug is entacapone?
COMT inhibitor
Entacapone is also known as what?
Entacapone is also known as what?
Comtan
Comtan is also known as what?
Comtan is also known as what?
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What are the uses for entacapone?
What are the uses for entacapone?
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Why is entacapone taken with levodopa?
Why is entacapone taken with levodopa?
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What is the regular dose of entacapone?
What is the regular dose of entacapone?
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What is the maximum dose of entacapone?
What is the maximum dose of entacapone?
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What are the contraindications of entacapone?
What are the contraindications of entacapone?
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What are the adverse effects of entacapone?
What are the adverse effects of entacapone?
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What patient education should be provided to a patient taking entacapone?
What patient education should be provided to a patient taking entacapone?
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What are the nursing interventions provided to patients taking entacapone?
What are the nursing interventions provided to patients taking entacapone?
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Entacapone interacts with what drugs?
Entacapone interacts with what drugs?
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What is the drug-drug interaction with entacapone and methyldopa?
What is the drug-drug interaction with entacapone and methyldopa?
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What is the drug-drug interaction with entacapone and dobutamine?
What is the drug-drug interaction with entacapone and dobutamine?
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What is the drug-drug interaction with entacapone and isoproterenol?
What is the drug-drug interaction with entacapone and isoproterenol?
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Study Notes
Mechanism of Action
- Entacapone inhibits the COMT enzyme, which reduces levodopa metabolism in the intestines and peripheral tissues.
Drug Classification
- Classified as a COMT inhibitor, which is relevant in Parkinson's disease management.
Brand Name
- Also known as Comtan, commonly used in clinical settings for Parkinson's treatment.
Usage
- Primarily combined with levodopa to enhance its efficacy and prolong its effects.
Dosing Information
- Regular doses of entacapone average at 200 mg per dose of levodopa.
- The maximum dosage allowed for entacapone is 1600 mg.
Patient Considerations
- It is contraindicated for individuals not taking levodopa.
- Adverse effects may include nausea, vomiting, diarrhea, constipation, yellow-orange urine, impulse control issues, and hallucinations.
Patient Education
- Patients should be informed of potential adverse effects.
- Stress the importance of adhering to the combination of entacapone with levodopa/carbidopa for effective treatment.
Nursing Interventions
- Nurses should monitor for adverse effects to evaluate if adjustments in levodopa dosing are necessary.
Drug Interactions
- Interacts with certain antihypertensives including methyldopa, dobutamine, and isoproterenol.
- Can increase methyldopa, dobutamine, and isoproterenol drug levels, warranting careful monitoring for these interactions.
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Description
This quiz covers the mechanism of action, classification, and usage of entacapone in treating Parkinson's disease. It highlights its role as a COMT inhibitor and the importance of combining it with levodopa. Understand the dosing information and patient considerations essential for effective treatment.
