Engineering Bone Tissue Grafts Quiz
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Questions and Answers

How is vascularization important in the development and repair of bone tissue according to the text?

  • Increased vascularization leads to decreased bone tissue regeneration
  • It does not play any significant role in bone tissue repair
  • Areas with less vascularization show more bone formation
  • Adequate vascularization is crucial for successful bone tissue repair and regeneration (correct)

Which type of cells are interfaced to three-dimensional porous biomaterial scaffolds in bone tissue engineering?

  • Nerve cells
  • Patient-specific osteocompetent cells (correct)
  • Muscle cells
  • Cancer cells

Why is it important to culture patient-specific cells under dynamic conditions in bioreactor systems?

  • To hinder nutrient supply to cells
  • To prevent cell proliferation
  • To promote efficient nutrition of cultured cells (correct)
  • To inhibit tissue differentiation

What is the main process involved in bone repair upon fracture?

<p>Intramembranous bone formation immediately occurs (C)</p> Signup and view all the answers

Which of the following is NOT a key principle for the success of Bone Tissue Engineering (BTE) as mentioned in the text?

<p>Direct application of mechanical stress for bone formation (B)</p> Signup and view all the answers

What are the main signalling molecules involved in regulating new bone formation upon fracture?

<p>ILs, TNF-α, FGFs, BMPs, PDGF, VEGF (A)</p> Signup and view all the answers

Which of the following is a crucial factor for bone structure and tissue engineering success?

<p>Phase separation and polymer demixing (C)</p> Signup and view all the answers

Why is it important to consider the native controlled distribution of non-mineralized and mineralized interface regions in tissue engineering?

<p>To maintain physiologic function and homeostasis (C)</p> Signup and view all the answers

What is a key factor that must be strategically incorporated into stratified scaffolds for interface tissue engineering?

<p>Spatial distribution and interactions between cells (D)</p> Signup and view all the answers

In the context of orthopaedic tissue engineering, what type of scaffold was developed by Lu et al. to mimic the ligament-to-bone interface tissue?

<p>Tri-phasic stratified scaffold (B)</p> Signup and view all the answers

How do multi-phased scaffolds contribute to tissue engineering according to the text?

<p>By supporting the formation of integrated multi-tissue systems (C)</p> Signup and view all the answers

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