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Engineering Bone Tissue Grafts Quiz

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Questions and Answers

How is vascularization important in the development and repair of bone tissue according to the text?

Increased vascularization leads to decreased bone tissue regeneration

It does not play any significant role in bone tissue repair

Areas with less vascularization show more bone formation

Adequate vascularization is crucial for successful bone tissue repair and regeneration (correct)

Which type of cells are interfaced to three-dimensional porous biomaterial scaffolds in bone tissue engineering?

Nerve cells

Patient-specific osteocompetent cells (correct)

Muscle cells

Cancer cells

Why is it important to culture patient-specific cells under dynamic conditions in bioreactor systems?

To hinder nutrient supply to cells

To prevent cell proliferation

To promote efficient nutrition of cultured cells (correct)

To inhibit tissue differentiation

What is the main process involved in bone repair upon fracture?

Intramembranous bone formation immediately occurs Signup and view all the answers

Which of the following is NOT a key principle for the success of Bone Tissue Engineering (BTE) as mentioned in the text?

Direct application of mechanical stress for bone formation Signup and view all the answers

What are the main signalling molecules involved in regulating new bone formation upon fracture?

ILs, TNF-α, FGFs, BMPs, PDGF, VEGF Signup and view all the answers

Which of the following is a crucial factor for bone structure and tissue engineering success?

Phase separation and polymer demixing Signup and view all the answers

Why is it important to consider the native controlled distribution of non-mineralized and mineralized interface regions in tissue engineering?

To maintain physiologic function and homeostasis Signup and view all the answers

What is a key factor that must be strategically incorporated into stratified scaffolds for interface tissue engineering?

Spatial distribution and interactions between cells Signup and view all the answers

In the context of orthopaedic tissue engineering, what type of scaffold was developed by Lu et al. to mimic the ligament-to-bone interface tissue?

Tri-phasic stratified scaffold Signup and view all the answers

How do multi-phased scaffolds contribute to tissue engineering according to the text?

By supporting the formation of integrated multi-tissue systems Signup and view all the answers