Endothelial Secretion Response to Thrombin Quiz

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What is one possible cause of platelet dysfunction mentioned in the text?

Increased release of arachidonic acid from membrane phospholipids
Increased contents of dense granules and alpha granules
Loss of platelet surface membrane a-adrenergic (epinephrine) receptors (correct)
Increased oxidation of arachidonic acid by the cyclooxygenase and lipoxygenase pathways

How does nitric oxide (NO) affect platelet aggregation according to the text?

Nitric oxide increases the production of arachidonic acid
Nitric oxide stimulates platelet aggregation
Nitric oxide has no effect on platelet aggregation
Nitric oxide inhibits platelet aggregation (correct)

What is the relationship between chronic liver disease and thrombocytopenia according to the text?

Chronic liver disease causes thrombocytopenia only in patients with hypersplenism
Chronic liver disease is not associated with thrombocytopenia
Chronic liver disease always causes severe thrombocytopenia
Mild to moderate thrombocytopenia is seen in approximately one third of patients with chronic liver disease (correct)

What is one potential cause of thrombocytopenia and platelet abnormalities in chronic alcoholic cirrhosis according to the text?

Direct toxic effects of alcohol on bone marrow megakaryocytes (C) Signup and view all the answers

Which of the following is not mentioned as a possible cause of platelet dysfunction in the text?

Increased loss of a variety of platelet membrane receptors for adhesion and activation (B) Signup and view all the answers

Which of the following is a potential cause of thrombocytopenia in liver disease?

Hypersplenism or alcohol toxicity (B) Signup and view all the answers

What is the main purpose of the Anticoagulant Protein System?

To regulate all enzymes of the coagulation and fibrinolytic systems (C) Signup and view all the answers

What is the primary function of the Fibrinolytic Protein System?

To lyse the clot formed by thrombin (C) Signup and view all the answers

What is the role of fibrinogen in the consolidation and stabilization of the platelet plug?

Fibrinogen provides a basis for platelet consolidation and stabilization by precipitating polymerized fibrin around each platelet. (C) Signup and view all the answers

Which of the following is not a component of the Cellular Components involved in Normal Hemostasis and Thrombosis?

Erythrocytes (C) Signup and view all the answers

What is the primary function of the Coagulation Protein System?

To serve as the system that forms thrombin, which initiates the proteolysis of fibrinogen, leading to fibrin clot formation (A) Signup and view all the answers

Which of the following is a method for the quantitative determination of platelets?

Examination of stained blood (B) Signup and view all the answers

What is the purpose of using thromboplastin reagent in the functional screening test mentioned in the text?

To assess the generation of thrombin and the formation of fibrin (B) Signup and view all the answers

How is thromboplastin reagent prepared for the functional screening test?

By tissue extraction from rabbit brain or lung (D) Signup and view all the answers

Which factor does thromboplastin form complexes with and activate?

Factor VII (A) Signup and view all the answers

What is the reference range for the International Normalized Ratio (INR) mentioned in the text?

10-13 (D) Signup and view all the answers

What was developed to standardize the sensitivity differences in individual thromboplastin reagents?

International Sensitivity Index (B) Signup and view all the answers

Which syndrome is characterized by congenital absence of the radial bones?

Thrombocytopenia with absent Radii Syndrome (TAR) (B) Signup and view all the answers

Where are alpha granules found in the body?

In platelets (D) Signup and view all the answers

What is a characteristic feature of Hermansky-Pudlak Syndrome?

Partial oculocutaneous albinism (C) Signup and view all the answers

Which syndrome is associated with giant lysosomal granules in cells?

Chédiak-Higashi Syndrome (B) Signup and view all the answers

What is a common feature of Chédiak-Higashi Syndrome?

Immunologic defects (A) Signup and view all the answers

Which disorder presents with ceroid-like deposition in reticuloendothelial cells?

Hermansky-Pudlak Syndrome (B) Signup and view all the answers

What is the role of tissue plasminogen activator (tPA) in the fibrinolytic system?

tPA converts inactive plasminogen to plasmin, which then lyses fibrin. (A) Signup and view all the answers

What are the products formed during the process of fibrinolysis?

D-dimers and cross-linked fibrin degradation products (XDP) (A) Signup and view all the answers

What is the primary function of the natural anticoagulants in the hemostatic system?

To ensure that the clot remains localized to the site of injury and prevent excessive clotting (B) Signup and view all the answers

What is the first step in the process of platelet-mediated hemostasis?

Platelet adhesion to the injured blood vessel wall (C) Signup and view all the answers

Which of the following statements regarding endothelial cells and the fibrinolytic system is correct?

In response to thrombin, endothelial secretion of tPA increases, promoting fibrinolysis. (C) Signup and view all the answers

What is the primary role of platelets in the hemostatic process?

To adhere to the site of vascular injury, aggregate, and form a platelet plug (D) Signup and view all the answers