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Coagulation in Vivo: Thrombin Generation

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Coagulation in Vivo: Thrombin Generation

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Questions and Answers

What is the role of platelet factor 3 in the coagulation cascade?

Providing a surface for phospholipid-mediated reactions (correct)
Synthesizing prostacyclin
Inhibiting platelet aggregation
Stimulating vascular smooth muscle cells to multiply

What is the product of the prothrombinase reaction?

Thrombin (correct)
Factor Xa
Factor IXa
Prothrombin

What is the effect of nitric oxide on platelet function?

Inhibits platelet activation (correct)
Has no effect on platelet function
Stimulates platelet activation
Promotes platelet aggregation

What is the role of CD39 in the intact vessel wall?

Preventing platelet aggregation (C) Signup and view all the answers

What is the effect of prostacyclin on blood vessels?

Vasodilation (C) Signup and view all the answers

What is the function of growth factor PDGF in platelets?

Stimulating vascular smooth muscle cells to multiply (A) Signup and view all the answers

What is the function of thromboxane A2 (TXA2) in platelet activation?

It lowers platelet cyclic adenosine monophosphate (cAMP) levels and initiates the release reaction. (A) Signup and view all the answers

What is the role of ADP released from dense granules in platelet activation?

It has a major positive feedback role in promoting platelet activation. (A) Signup and view all the answers

What is the effect of prostacyclin (PGI2) on platelet aggregation?

It is a potent inhibitor of platelet aggregation. (C) Signup and view all the answers

What is the role of α granule contents in platelet activation?

They have an important role in platelet aggregate formation and stabilization. (D) Signup and view all the answers

What is the role of calcium in the generation of thrombin?

It is a cofactor in the enzyme complexes involved in thrombin generation. (B) Signup and view all the answers

What is the result of primary activation by various agonists in platelets?

It induces intracellular signalling, leading to the release of α granule contents. (C) Signup and view all the answers