Coagulation in Vivo: Thrombin Generation
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Questions and Answers

What is the role of platelet factor 3 in the coagulation cascade?

  • Providing a surface for phospholipid-mediated reactions (correct)
  • Synthesizing prostacyclin
  • Inhibiting platelet aggregation
  • Stimulating vascular smooth muscle cells to multiply
  • What is the product of the prothrombinase reaction?

  • Thrombin (correct)
  • Factor Xa
  • Factor IXa
  • Prothrombin
  • What is the effect of nitric oxide on platelet function?

  • Inhibits platelet activation (correct)
  • Has no effect on platelet function
  • Stimulates platelet activation
  • Promotes platelet aggregation
  • What is the role of CD39 in the intact vessel wall?

    <p>Preventing platelet aggregation</p> Signup and view all the answers

    What is the effect of prostacyclin on blood vessels?

    <p>Vasodilation</p> Signup and view all the answers

    What is the function of growth factor PDGF in platelets?

    <p>Stimulating vascular smooth muscle cells to multiply</p> Signup and view all the answers

    What is the function of thromboxane A2 (TXA2) in platelet activation?

    <p>It lowers platelet cyclic adenosine monophosphate (cAMP) levels and initiates the release reaction.</p> Signup and view all the answers

    What is the role of ADP released from dense granules in platelet activation?

    <p>It has a major positive feedback role in promoting platelet activation.</p> Signup and view all the answers

    What is the effect of prostacyclin (PGI2) on platelet aggregation?

    <p>It is a potent inhibitor of platelet aggregation.</p> Signup and view all the answers

    What is the role of α granule contents in platelet activation?

    <p>They have an important role in platelet aggregate formation and stabilization.</p> Signup and view all the answers

    What is the role of calcium in the generation of thrombin?

    <p>It is a cofactor in the enzyme complexes involved in thrombin generation.</p> Signup and view all the answers

    What is the result of primary activation by various agonists in platelets?

    <p>It induces intracellular signalling, leading to the release of α granule contents.</p> Signup and view all the answers

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