12 Questions
What is the role of platelet factor 3 in the coagulation cascade?
Providing a surface for phospholipid-mediated reactions
What is the product of the prothrombinase reaction?
Thrombin
What is the effect of nitric oxide on platelet function?
Inhibits platelet activation
What is the role of CD39 in the intact vessel wall?
Preventing platelet aggregation
What is the effect of prostacyclin on blood vessels?
Vasodilation
What is the function of growth factor PDGF in platelets?
Stimulating vascular smooth muscle cells to multiply
What is the function of thromboxane A2 (TXA2) in platelet activation?
It lowers platelet cyclic adenosine monophosphate (cAMP) levels and initiates the release reaction.
What is the role of ADP released from dense granules in platelet activation?
It has a major positive feedback role in promoting platelet activation.
What is the effect of prostacyclin (PGI2) on platelet aggregation?
It is a potent inhibitor of platelet aggregation.
What is the role of α granule contents in platelet activation?
They have an important role in platelet aggregate formation and stabilization.
What is the role of calcium in the generation of thrombin?
It is a cofactor in the enzyme complexes involved in thrombin generation.
What is the result of primary activation by various agonists in platelets?
It induces intracellular signalling, leading to the release of α granule contents.
Understand the complex process of thrombin generation in vivo, involving enzyme complexes, platelet release reaction, and amplification. Learn about the role of protease, cofactor, phospholipids, and calcium in this process.
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