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Endoplasmic Reticulum: Targeting Nascent Proteins Quiz

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Endoplasmic Reticulum: Targeting Nascent Proteins Quiz

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Questions and Answers

What is the function of the signal recognition particle (SRP) in the process of targeting nascent proteins to the endoplasmic reticulum?

SRP binds to nascent signal sequence and arrests translation, then binds to SRP receptor on ER membrane to direct the ribosome-nascent chain complex to the ER translocon channel.

Who discovered the signal recognition particle (SRP) and where?

Peter Walter discovered SRP in the Blobel lab.

What is the main role of the SRP 54 (S) subunit within the signal recognition particle (SRP)?

SRP 54 (S) binds the signal sequence, ribosome, and SRP receptor.

Why does the SRP block in vitro translation of nascent chains with a signal sequence?

SRP blocks translation because it binds to nascent signal sequences and arrests translation. Signup and view all the answers

What is the significance of the salt wash assay in the study of targeting nascent proteins to the endoplasmic reticulum?

The salt wash assay guides the purification of molecules responsible for restoring activity, such as SRP. Signup and view all the answers

What is the role of SRP in the process of protein synthesis?

SRP brings translating polyribosome to the ER and helps target the ribosome to the translocon pore. Signup and view all the answers

What is the significance of methionine in the interaction between SRP and SR?

Methionine bristles line a hydrophobic grove, facilitating the binding of SRP54 to SR in a 2-fold symmetric fashion. Signup and view all the answers

Why is GTP important in the SRP-SR interaction?

GTP is required for the interaction between SRP and SR, and its hydrolysis causes dissociation. Signup and view all the answers

What must be the form of SR beta to bind to SR alpha?

SR beta must be in the GTP form to bind to SR alpha. Signup and view all the answers

What happens to the ribosome after SRP is released in the protein translocation process?

The ribosome binds to the translocon, and the nascent chain enters the translocon. Signup and view all the answers