Endoplasmic Reticulum: Targeting Nascent Proteins Quiz

SRP binds to nascent signal sequence and arrests translation, then binds to SRP receptor on ER membrane to direct the ribosome-nascent chain complex to the ER translocon channel.

Peter Walter discovered SRP in the Blobel lab.

SRP 54 (S) binds the signal sequence, ribosome, and SRP receptor.

<p>SRP blocks translation because it binds to nascent signal sequences and arrests translation.</p> Signup and view all the answers

<p>The salt wash assay guides the purification of molecules responsible for restoring activity, such as SRP.</p> Signup and view all the answers

<p>SRP brings translating polyribosome to the ER and helps target the ribosome to the translocon pore.</p> Signup and view all the answers

<p>Methionine bristles line a hydrophobic grove, facilitating the binding of SRP54 to SR in a 2-fold symmetric fashion.</p> Signup and view all the answers

<p>GTP is required for the interaction between SRP and SR, and its hydrolysis causes dissociation.</p> Signup and view all the answers

<p>SR beta must be in the GTP form to bind to SR alpha.</p> Signup and view all the answers

<p>The ribosome binds to the translocon, and the nascent chain enters the translocon.</p> Signup and view all the answers