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12 Questions

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Endometriosis Theories

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Questions and Answers

What is the main focus of the Meyer theory regarding the development of endometriosis?

Coelomic metaplasia of multipotential cells in the peritoneal cavity (correct)

Development of endometriosis after the onset of menstruation

Immunologic factors leading to endometriosis

Endometrial cell implantation during menstruation

According to the Sampson theory, what is the common explanation for the development of pelvic endometriosis and its predilection for certain sites?

Immunologic factors leading to endometriosis

Direct implantation of endometrial cells through retrograde menstruation (correct)

Development of endometriosis after the onset of menstruation

Coelomic metaplasia of multipotential cells in the peritoneal cavity

What characteristic distinguishes pelvic endometriosis according to the Sampson theory?

Development after the onset of menstruation

Implantation in the pelvic and ovaries (correct)

Presence of immunologic factors

Occurrence in abdominal incisions or scars

In which scenario would remnant endometrial glands most likely deposit and lead to endometriosis according to the Sampson theory?

Accidental fistula connecting the uterus to the abdominal wall in a patient with a C-section Signup and view all the answers

What is the classic sign of uterosacral nodularity in ovarian endometriomas?

Chocolate cyst Signup and view all the answers

In patients with dyspareunia, what differential diagnoses should be considered?

Chronic pelvic inflammatory disease, ovarian cysts, and symptomatic uterine retroversion Signup and view all the answers

What may cause sudden abdominal pain in addition to a ruptured endometrioma?

Ectopic pregnancy and acute pelvic inflammatory disease Signup and view all the answers

What may the uterus be relatively fixed and retroflexed in the pelvis due to?

Extensive adhesions Signup and view all the answers

What is the purpose of add-back therapy in the context of GnRH agonist treatment?

To counteract the hypoestrogenic effect and mitigate the vasomotor and bone density side effects Signup and view all the answers

When might Norethindrone acetate 5 mg be required for a patient undergoing GnRH agonist therapy?

If a patient develops side effects while taking a GnRH agonist, if the therapy is required for longer than 6 months, or if repeated treatments are required Signup and view all the answers

What is the primary function of GnRH agonists and antagonists in the context of endometriosis treatment?

To block the production of ovarian-stimulating hormones, lowering estrogen levels and preventing menstruation Signup and view all the answers

Why is add-back therapy often started with GnRH agonist therapy?

Because it does not affect the drug's control of pelvic pain Signup and view all the answers