Endometrial Adenocarcinoma Risk Factors and Screening

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the most common type of endometrial cancer?

  • Endometrioid adenocarcinoma (correct)
  • Clear cell carcinoma
  • Serous carcinoma
  • Squamous cell carcinoma

What is the average age at diagnosis of endometrial cancer?

  • 61 (correct)
  • 55
  • 45
  • 70

Which of the following factors is NOT a known risk factor for endometrial cancer?

  • Obesity
  • Nulliparity
  • Early menopause (correct)
  • Diabetes mellitus

What is the recommended screening method for women with Lynch syndrome to detect endometrial cancer?

<p>Endometrial biopsy (D)</p> Signup and view all the answers

Which symptom is the most common presentation of endometrial cancer?

<p>Abnormal vaginal bleeding (C)</p> Signup and view all the answers

At what age should women with Lynch syndrome start routine screening for endometrial cancer?

<p>At age 30 or 5-10 years before the earliest age of diagnosis in the family (B)</p> Signup and view all the answers

What type of tissue does the basement membrane separate from the underlying connective tissue?

<p>Endothelium (B)</p> Signup and view all the answers

Which term describes a malignant tumor of the bone?

<p>Osteosarcoma (C)</p> Signup and view all the answers

What is the characteristic muscle tissue affected by Uterine Leiomyosarcoma?

<p>Smooth muscle (D)</p> Signup and view all the answers

Which malignant tumor is associated with the skeletal muscle?

<p>Rhabdomyosarcoma (C)</p> Signup and view all the answers

What is the characteristic feature of Neuroblastoma?

<p>Malignancy of the nerve cell (B)</p> Signup and view all the answers

Which cancer type involves cancer of the white blood cells?

<p>Lymphoma (D)</p> Signup and view all the answers

What is the recommended platelet count range to maintain during chemotherapy?

<p>20,000 to 30,000 microL (A)</p> Signup and view all the answers

Which chemotherapeutic side effect is characterized by low levels of neutrophils, red blood cells, and platelets?

<p>Pancytopenia (D)</p> Signup and view all the answers

Which body system is affected by cardiomyopathy, a potential side effect of chemotherapy?

<p>Cardiovascular system (B)</p> Signup and view all the answers

What is a common symptom associated with nephropathy, one of the potential side effects of chemotherapy?

<p>Kidney damage (C)</p> Signup and view all the answers

Which potential side effect of chemotherapy is characterized by inflammation in the bladder leading to blood in the urine?

<p>Hemorrhagic cystitis (C)</p> Signup and view all the answers

What is the normal range for Alpha-fetoprotein?

<p>1-15 ng/ml (D)</p> Signup and view all the answers

Which tumor marker is associated with levels > 50 ng/ml consistent with Colorectal Cancer?

<p>Carcinoembryonic Antigen (CEA) (D)</p> Signup and view all the answers

What is the normal range for Prostate Specific Antigen?

<p>&gt; 4.0 ng/ml (C)</p> Signup and view all the answers

For which cancer is CA-27-29 a tumor marker?

<p>Breast cancer (D)</p> Signup and view all the answers

In a metastatic workup, what evaluation is typically needed if a mass is identified in the chest?

<p>Contrast-enhanced CT (D)</p> Signup and view all the answers

What clinical parameters indicate that a bone scan is not needed during a metastatic workup?

<p>Normal alkaline phosphatase levels and no bone pain (D)</p> Signup and view all the answers

Which of the following is NOT a clinical manifestation of Tumor Lysis Syndrome?

<p>Hypertension (C)</p> Signup and view all the answers

What is one of the preexisting clinical risk factors for Tumor Lysis Syndrome?

<p>Oliguria (A)</p> Signup and view all the answers

Which electrolyte abnormality is a diagnostic criterion for Tumor Lysis Syndrome?

<p>Potassium ≥ 6 mEq/L or 25% increase above baseline (D)</p> Signup and view all the answers

What is the pharmacological agent used in the management of Tumor Lysis Syndrome to convert uric acids into an inactive metabolite?

<p>Rasburicase (Elitek) (B)</p> Signup and view all the answers

Which of the following is part of the laboratory diagnostic criteria for Tumor Lysis Syndrome?

<p>Phosphorus ≥ 6.5 mg/dl or 25% increase above baseline (C)</p> Signup and view all the answers

What is a contraindication for using Rasburicase (Elitek) in the management of Tumor Lysis Syndrome?

<p>Sodium bicarbonate use (A)</p> Signup and view all the answers

What is the most common bone site affected by multiple myeloma?

<p>Vertebrae (D)</p> Signup and view all the answers

Which of the following symptoms is NOT typically associated with multiple myeloma?

<p>Visual disturbances (D)</p> Signup and view all the answers

What characteristic finding would a urinalysis show in a suspected multiple myeloma case?

<p>Proteinuria (B)</p> Signup and view all the answers

Which of the following laboratory findings is indicative of multiple myeloma?

<p>Rouleaux formation (A)</p> Signup and view all the answers

What imaging modality is commonly used to identify lytic lesions in suspected multiple myeloma cases?

<p>X-ray (D)</p> Signup and view all the answers

Which electrolyte abnormality is often seen in individuals with multiple myeloma?

<p>Hypercalcemia (A)</p> Signup and view all the answers

What is a key feature of the urine dipstick result in suspected multiple myeloma cases?

<p>Negative for protein (D)</p> Signup and view all the answers

What is the appropriate timeframe for initiating antibiotic therapy after obtaining blood cultures for a patient presenting with symptoms of infection?

<p>Within 60 minutes (D)</p> Signup and view all the answers

Which of the following fungal pathogens is commonly associated with invasive fungal infections in patients with neutropenia?

<p>Candida spp (C)</p> Signup and view all the answers

In the management of neutropenic fever, what antifungal agent can be initiated if a patient remains febrile at 4 days or develops new pulmonary infiltrates during therapy?

<p>Caspofungin (A)</p> Signup and view all the answers

Which of the following antibiotics is considered an antipseudomonal beta-lactam agent in the context of bacterial coverage for neutropenic fever?

<p>Cefepime (B)</p> Signup and view all the answers

What is the recommended treatment for low-risk neutropenic fever patients who can be managed as outpatients?

<p>Oral ciprofloxacin with oral Augmentin (C)</p> Signup and view all the answers

For high-risk neutropenic fever patients, what action should be taken if they are still febrile at 4 days or have new pulmonary infiltrates during therapy?

<p>Commence empiric antifungal therapy (B)</p> Signup and view all the answers

What additional agents may be added in the management of low-risk neutropenic fever patients who present with complications or suspected antimicrobial resistance?

<p>Aminoglycosides, fluoroquinolones, or vancomycin (A)</p> Signup and view all the answers

What is the definition of neutropenia in terms of ANC?

<p>ANC &lt; 1500/mcl (B)</p> Signup and view all the answers

When is granulocyte stimulating factor (neupogen) typically ordered?

<p>When ANC is &lt; 500 (A)</p> Signup and view all the answers

What is the increased risk associated with neutropenia lasting more than 7 days?

<p>Increased risk of infection (B)</p> Signup and view all the answers

What are low risk patients characterized by in the context of neutropenia?

<p>ANC &lt; 500 for ≤ 7 days (A)</p> Signup and view all the answers

What should be initiated in high-risk patients with neutropenic fever?

<p>Empiric antibiotic therapy (C)</p> Signup and view all the answers

Which organisms are the most common cause of neutropenic fever?

<p>Gram-positive bacteria (C)</p> Signup and view all the answers

What is the formula used to calculate Absolute Neutrophil Count (ANC)?

<p>(WBC x % neutrophils) x 1000 (C)</p> Signup and view all the answers

Which chemotherapeutic agent is associated with side effects including photosensitivity, anorexia, hypotension, and flu-like symptoms?

<p>Dacarbazine (A)</p> Signup and view all the answers

Which chemotherapeutic drug is linked to neurotoxicity as one of its adverse effects?

<p>Cisplatin (C)</p> Signup and view all the answers

Among the listed chemotherapeutic agents, which one is not known for causing alopecia?

<p>Methotrexate (C)</p> Signup and view all the answers

Which side effect is commonly experienced with Cytarabine treatment?

<p>Nausea and vomiting (D)</p> Signup and view all the answers

What is a notable adverse effect of Ifosfamide that distinguishes it from the other chemotherapeutic agents listed?

<p>Neurotoxicity (D)</p> Signup and view all the answers

Which chemotherapeutic agent is primarily associated with electrolyte imbalances as one of its main side effects?

<p>Platinol (C)</p> Signup and view all the answers

Among the listed chemotherapeutic drugs, which one can cause hemorrhagic cystitis?

<p>Methotrexate (D)</p> Signup and view all the answers

What is the most common site affected by malignant spinal cord compression?

<p>Thoracic spine (B)</p> Signup and view all the answers

What is the typical timing relationship between the onset of back pain and neurologic symptoms in malignant spinal cord compression?

<p>Back pain precedes neurologic symptoms (A)</p> Signup and view all the answers

Which of the following is indicative of spine instability in the context of malignant spinal cord compression?

<p>Pain only on movement (D)</p> Signup and view all the answers

What is a late finding associated with malignant spinal cord compression?

<p>Bowel dysfunction (A)</p> Signup and view all the answers

In the context of imaging for malignant spinal cord compression, what contrast is recommended in MRI scans?

<p>Contrast with and without contrast (D)</p> Signup and view all the answers

What treatment is generally indicated for spine instability in malignant spinal cord compression?

<p>Surgery (D)</p> Signup and view all the answers

What is the initial dose of Dexamethasone given in the treatment of malignant spinal cord compression?

<p>10 mg IV bolus (D)</p> Signup and view all the answers

Which condition may be prevented with VTE prophylaxis in patients with malignant spinal cord compression?

<p>Deep vein thrombosis (C)</p> Signup and view all the answers

What may avoid the need for surgery in malignant spinal cord compression?

<p>'Radiation therapy' (A)</p> Signup and view all the answers

Flashcards are hidden until you start studying

Related Documents

Oncology 2020 PDF

More Like This

Use Quizgecko on...
Browser
Browser