Endogenous Pigments: Lipofuscin
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Questions and Answers

What is another name for lipofuscin?

  • Oxidative pigment
  • Proteofuscin
  • Yellow lipid
  • Aging pigment (correct)

Where is lipofuscin accumulation commonly observed?

  • Skin and hair of children
  • Liver and heart of elderly people (correct)
  • Brain and lungs of young adults
  • Muscles of athletes

What is the main function of melanin in the skin?

  • Regulating temperature
  • Providing protection against UV radiation (correct)
  • Maintaining hydration
  • Enhancing tactile sensation

Which cells produce melanin in the skin?

<p>Melanocytes (D)</p> Signup and view all the answers

Which condition is characterized by the localization and depth of pigment in melanocytes?

<p>Melanocytic nevus (D)</p> Signup and view all the answers

What is a common sign that points out the malignant transformation of a nevus?

<p>Growth in mass (A)</p> Signup and view all the answers

In what races is physiological pigmentation commonly seen?

<p>Caucasian and Black race (B)</p> Signup and view all the answers

Which factor stimulates melanocytes due to increased estrogen levels?

<p>Pigment distribution (D)</p> Signup and view all the answers

What type of nevus results from malignant degeneration of nevi with junction activity?

<p>Junction nevus (D)</p> Signup and view all the answers

Which condition is characterized by small yellow-brown macules and is related to exposure to ultraviolet light?

<p>Freckle (Efelide) (C)</p> Signup and view all the answers

Where is smoking-related melanosis commonly observed?

<p>Maxillary anterior region (A)</p> Signup and view all the answers

What causes pigmentation along the gingival edges when taking medicine containing arsenic or drinking water contaminated with arsenic?

<p>Arsenic poisoning (D)</p> Signup and view all the answers

What is a potential indication of Peutz-Jeghers or Addison’s disease when freckles increase around the mouth?

<p>Increased melanin production (A)</p> Signup and view all the answers

Which type of pigmentation can occur in children who have a habit of pencil biting?

<p>Graphite pigmentation (A)</p> Signup and view all the answers

What is responsible for systemic melanin hyperpigmentation in chronic poisonings caused by organic mercury compounds?

<p>Increased melanin production (C)</p> Signup and view all the answers

Which drug used in AIDS treatment can cause pigmentation in the mucosa or teeth when taken for long periods?

<p>Zidovudine (C)</p> Signup and view all the answers

In nevus classification, which type of classification is associated with melanoma formation?

<p>Junctional nevus (C)</p> Signup and view all the answers

What is the result of chronic poisoning from drugs containing arsenic on pigmentation?

<p>Permanent melanin hyperpigmentation (A)</p> Signup and view all the answers

Flashcards

Aging pigment

A synonym for lipofuscin, which is commonly observed in the liver and heart of elderly people.

Where is lipofuscin accumulation observed?

Accumulation of lipofuscin, a pigment associated with aging, is commonly observed in the liver and heart of elderly people.

Melanin's main function

Melanin, a pigment found in the skin, primarily serves to protect against harmful UV radiation from the sun.

Melanin producing cells

Melanocytes are specialized cells located in the skin that are responsible for producing melanin.

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Melanocytic nevus

A melanocytic nevus refers to a pigmented lesion where the distribution and depth of pigment in melanocytes are localized.

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Malignant transformation of a nevus

A malignant transformation of a nevus is often indicated by growth in mass, suggesting a potential risk factor for melanoma.

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Physiological pigmentation in races

Caucasian and Black races commonly exhibit physiological pigmentation, which refers to the natural skin color variation.

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Estrogen's effect on melanocytes

Increased estrogen levels stimulate melanocytes, influencing pigment distribution, particularly during pregnancy or hormonal changes.

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Junction nevus

A junction nevus is a type of nevus that originates from the junction of the epidermis and dermis, often considered a precursor to melanoma.

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Freckles

Freckles, also known as ephelides, are small, yellow-brown macules that are commonly associated with exposure to ultraviolet light.

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Smoking-related melanosis

Smoking-related melanosis is a condition characterized by pigmentation in the maxillary anterior region, often observed in smokers.

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Arsenic poisoning and pigmentation

Arsenic poisoning can cause pigmentation along the gingival edges, a result of arsenic exposure either through medication or contaminated water.

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Freckles around the mouth

An increase in freckles around the mouth can sometimes indicate Peutz-Jeghers or Addison’s disease, suggesting increased melanin production.

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Graphite pigmentation

Graphite pigmentation, commonly seen in children who bite pencils, is the result of graphite particles embedding themselves in the oral mucosa.

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Mercury poisoning and pigmentation

Systemic melanin hyperpigmentation can occur as a result of chronic poisonings caused by exposure to organic mercury compounds, due to increased melanin production.

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Zidovudine pigmentation

Zidovudine, a drug used in AIDS treatment, can cause pigmentation in the mucosa or teeth after long-term use.

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Junctional nevus and melanoma

Junctional nevus, a type of nevus associated with melanoma formation, involves the junction of the epidermis and dermis where melanocytes reside.

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Arsenic poisoning: Permanent pigmentation

Chronic poisoning from drugs containing arsenic can lead to permanent melanin hyperpigmentation, resulting in a change in skin color.

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