Endocrine & Thyroid Diseases Quiz
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Questions and Answers

What is the primary cause of primary hypothyroidism in dogs?

  • Destruction of the thyroid gland (correct)
  • Tumors in the thyroid
  • Genetic predisposition
  • Congenital defects
  • Which treatment is considered the most effective for hyperthyroid disease in cats?

  • Diet modification
  • Radioactive iodine therapy (correct)
  • Surgical removal of the thyroid gland
  • Antithyroid drug therapy
  • What is the average survival time for dogs with hyperadrenocorticism regardless of treatment?

  • Approximately 2 years (correct)
  • Less than 1 year
  • Over 3 years
  • Around 5 years
  • Which condition is characterized by inflammation of the pancreas in dogs and cats?

    <p>Pancreatitis (A)</p> Signup and view all the answers

    What is a common clinical sign associated with hypothyroidism in dogs?

    <p>Weight gain (B)</p> Signup and view all the answers

    What common dietary issue is linked to pancreatitis in dogs?

    <p>High fat diet (A)</p> Signup and view all the answers

    Which breed is NOT typically predisposed to Addison's disease?

    <p>Siberian Huskies (D)</p> Signup and view all the answers

    Which breed is NOT commonly associated with genetic predisposition to exocrine pancreatic insufficiency?

    <p>Golden Retriever (D)</p> Signup and view all the answers

    Which hormone levels are assessed in the ACTH stimulation test for diagnosing Addison's disease?

    <p>Cortisol concentrations (B)</p> Signup and view all the answers

    What is a characteristic clinical sign of Cushing's syndrome in dogs?

    <p>Abdominal distension (C)</p> Signup and view all the answers

    During the evaluation of a dog suspected of having pancreatitis, which laboratory finding would likely be observed?

    <p>Hypocalcemia (A)</p> Signup and view all the answers

    Which of the following is a potential side effect of hyperthyroid treatment with antithyroid drugs?

    <p>Transdermal absorption complications (A)</p> Signup and view all the answers

    What gastrointestinal sign can indicate the presence of pancreatitis?

    <p>Persistent vomiting (A)</p> Signup and view all the answers

    Which distemper vaccine is contraindicated in young dogs?

    <p>Live attenuated vaccine (A)</p> Signup and view all the answers

    What initial treatment approach is recommended for severe pancreatitis?

    <p>NPO (nothing by mouth) for 3-4 days (A)</p> Signup and view all the answers

    What clinical sign is commonly associated with maldigestion due to exocrine pancreatic insufficiency?

    <p>Steatorrhea (fatty stools) (B)</p> Signup and view all the answers

    In which condition is an enlarged thyroid gland typically palpated?

    <p>Hyperthyroidism (D)</p> Signup and view all the answers

    Which of the following describes a common predisposing factor for Cushing's syndrome in dogs?

    <p>Middle to older ages (D)</p> Signup and view all the answers

    Which of the following treatments is effective for managing exocrine pancreatic insufficiency?

    <p>Pancreatic enzyme replacement therapy (B)</p> Signup and view all the answers

    Which diagnostic method is used to assess pancreatic function?

    <p>Fecal elastase assay (B)</p> Signup and view all the answers

    What is the primary hormonal function of the thyroid gland in animals?

    <p>Controlling metabolism and calcium levels (B)</p> Signup and view all the answers

    Which breed of dog has a noted genetic predisposition to develop hypothyroidism?

    <p>Dachshund (A)</p> Signup and view all the answers

    Which clinical sign is least likely to be associated with hyperthyroidism in cats?

    <p>Weight gain (B)</p> Signup and view all the answers

    What type of veterinary treatment approach is indicated for a dog diagnosed with Addison's disease?

    <p>Long-term hormone replacement therapy (D)</p> Signup and view all the answers

    What is the most common cause of hyperadrenocorticism in dogs?

    <p>Pituitary dependent hyperadrenocorticism (C)</p> Signup and view all the answers

    What clinical sign is commonly observed in both Cushing’s syndrome and diabetes mellitus in dogs?

    <p>Increased urination and thirst (C)</p> Signup and view all the answers

    Which diagnostic test is used to differentiate between types of Cushing's syndrome in dogs?

    <p>High-dose dexamethasone suppression test (D)</p> Signup and view all the answers

    What is a potential complication of hyperthyroidism treatment in cats using radioactive iodine?

    <p>Thyrotoxic hypertrophic cardiomyopathy (D)</p> Signup and view all the answers

    Which treatment method for hyperthyroidism in cats involves lifelong dietary restrictions?

    <p>Iodine deficient diet (A)</p> Signup and view all the answers

    What condition is characterized by the destruction of the thyroid gland leading to hormone deficiency?

    <p>Primary hypothyroidism (D)</p> Signup and view all the answers

    What is a significant factor that may influence the survival of a dog with early hyperadrenocorticism?

    <p>Presence of comorbidities (B)</p> Signup and view all the answers

    Which of the following is a potential result of pancreatitis not directly associated with the pancreas?

    <p>Hypocalcemia (A)</p> Signup and view all the answers

    What is a common clinical sign indicative of exocrine pancreatic insufficiency?

    <p>Pale, voluminous feces (A)</p> Signup and view all the answers

    Which breed is particularly prone to developing exocrine pancreatic insufficiency based on genetic factors?

    <p>Cavalier King Charles Spaniel (B)</p> Signup and view all the answers

    What is the first line of treatment often recommended for a dog diagnosed with severe pancreatitis?

    <p>Aggressive fluid therapy (C)</p> Signup and view all the answers

    Which laboratory test is specifically used to assess pancreatic function in a dog suspected of having exocrine pancreatic insufficiency?

    <p>Serum trypsin-like immunoreactivity (C)</p> Signup and view all the answers

    Which of the following dietary factors is associated with the development of pancreatitis in dogs?

    <p>High fat diet (C)</p> Signup and view all the answers

    What symptom might a dog with EPI exhibit despite having a normal appetite?

    <p>Weight loss (C)</p> Signup and view all the answers

    Which of the following is NOT a potential cause of pancreatitis in dogs?

    <p>Low calcium levels (B)</p> Signup and view all the answers

    In dogs diagnosed with pancreatitis, which of the following findings is most likely to be present on a chemistry panel?

    <p>Hyperlipidemia (A)</p> Signup and view all the answers

    Flashcards

    Hypothyroidism in dogs

    A common disease in dogs characterized by an underactive thyroid gland, leading to decreased metabolic rate and various clinical signs.

    Primary Hypothyroidism

    A type of hypothyroidism caused by destruction of the thyroid gland itself, often due to autoimmune disease or gland atrophy.

    Hyperthyroidism in cats

    A common disease in cats characterized by an overactive thyroid gland, resulting in excess thyroid hormones.

    Radioactive Iodine (I-131)

    A curative treatment for hyperthyroidism in cats, which involves radioactive material destroying the diseased thyroid cells.

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    Addison's Disease (Hypoadrenocorticism)

    A disease characterized by a lack of glucocorticoids and/or mineralocorticoids, affecting hormone production in the adrenal glands.

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    Cushing's Disease

    A condition of elevated cortisol concentrations, often resulting from pituitary or adrenal problems.

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    Pituitary-Dependent Hyperadrenocorticism (PDH)

    A type of Cushing's disease where the pituitary gland overproduces ACTH, causing the adrenal glands to produce excessive cortisol.

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    Low dose dexamethasone suppression test (LDDST)

    A common screening test for Cushing's Syndrome, used to differentiate between types of hyperadrenocorticism.

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    Thyroid Stimulating Hormone (TSH)

    A blood test used to determine the activity state of the thyroid axis.

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    Mineralocorticoids

    Hormones produced in the adrenal glands, vital for sodium and potassium balance.

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    Dog Pancreatitis

    Inflammation of the dog's pancreas, often acute or chronic, potentially severe and necrotizing. Pancreatic secretions decrease and enzymes increase, causing auto-digestion.

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    Pancreatitis Causes

    Can be many things; high-fat diets, genetic predisposition in specific breeds, certain medications, trauma, tumors, or sometimes unknown.

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    Pancreatitis Clinical Signs

    Symptoms include nausea, abdominal pain (praying pose), anorexia, vomiting, diarrhea, weakness, and potentially fever. Can be less severe.

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    Pancreatitis Diagnosis

    Diagnosis often involves tests like a SNAP test, pancreatic lipase immunoreactivity, imaging (X-rays), blood tests (looking for enzyme levels, etc.), and a complete blood count.

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    Pancreatitis Treatment

    Fluid therapy, NPO (nothing by mouth), antibiotics, pain relief, and a low-fat diet are common treatment strategies. Severe cases may include plasma or albumin therapy.

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    Exocrine Pancreatic Insufficiency (EPI)

    EPI is a condition where the pancreas fails to produce enough digestive enzymes for proper nutrient absorption.

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    EPI Clinical Signs

    EPI causes maldigestion and malabsorption, leading to weight loss, voluminous, pale, and oily stools (steatorrhea).

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    EPI Treatment

    Treatment typically involves enzyme replacements (powdered forms are often more effective), vitamins (especially B12), and possibly probiotics or antibiotics.

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    EPI Diagnosis

    Diagnosis of EPI involves measuring serum trypsin-like immunoreactivity and/or fecal elastase levels, alongside clinical signs.

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    Prognosis for Pancreas Conditions

    Survival can vary considerably, ranging from approximately two years (or less without treatment) to much longer with early-stage treatment and the absence of other health problems.

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    Pancreatitis

    Inflammation of the pancreas, a common problem in dogs and cats. It can be acute or chronic, and in severe cases, can be very damaging to the pancreas.

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    Causes of Pancreatitis

    The cause of pancreatitis is sometimes unknown, but factors like high-fat diets, obesity, high cholesterol, trauma, and certain medications can contribute.

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    Pancreatitis Symptoms

    Common symptoms include nausea, abdominal pain (praying posture), loss of appetite, vomiting, diarrhea, weakness, and sometimes fever.

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    EPI Symptoms

    Typical symptoms include weight loss despite a normal appetite, loose, voluminous, pale, and oily stools, and sometimes vomiting.

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    What role do the thyroid hormones play in the body?

    Thyroid hormones (T3 and T4) regulate metabolism in the body, controlling how quickly the body burns energy.

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    What is hypothyroidism?

    Hypothyroidism occurs when the thyroid gland is underactive, leading to decreased production of thyroid hormones, resulting in a slower metabolic rate.

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    What are some clinical signs of hypothyroidism in dogs?

    Signs include lethargy, weight gain, hair loss, skin problems like alopecia, and recurrent skin infections.

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    How is hyperthyroidism diagnosed in cats?

    Diagnosis usually involves blood tests to check T4 levels, physical exam, possibly palpating an enlarged thyroid gland, and monitoring for clinical signs.

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    What is the most common treatment for hyperthyroidism in cats?

    Radioactive iodine (I-131) is the most effective treatment, targeting and destroying the overactive thyroid cells.

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    Explain the concept of Addisons disease.

    Addisons disease, or hypoadrenocorticism, occurs when the adrenal glands don't produce enough cortisol and aldosterone.

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    What are some clinical signs of Addisons disease?

    Signs include weakness, lethargy, vomiting, diarrhea, dehydration, and potential for an Addisonian crisis.

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    What is Cushing's disease?

    Cushing's disease, or hyperadrenocorticism, occurs when the body produces too much cortisol.

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    What are some common clinical signs of Cushing's disease?

    Signs include pot belly, increased thirst and urination, hair loss, muscle wasting, and susceptibility to UTIs.

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    What are the treatment options for Cushing's disease?

    Treatment options include medical management with drugs like mitotane or trilostane, surgery, and radiotherapy.

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    Study Notes

    Endocrine & Pancreas Diseases

    • Oversees and integrates body functions using hormones
    • Includes glands like pituitary, thyroid, parathyroid, adrenals, pancreas, and gonads
    • Brain controls endocrine gland secretions and regulates water balance, metabolism, and body temperature
    • Diseases often stem from autoimmune attacks or organ malfunction (over/under production of hormones)

    Thyroid Gland

    • Located ventrally in the cervical region, along the lateral margins of the trachea
    • Non-palpable in healthy animals
    • Produces hormones T3 and T4, which regulate metabolism
    • Produces calcitonin to control free calcium in the blood
    • Underactive/overactive states can cause disease

    Hypothyroid Disease

    • Common in dogs (especially Golden Retrievers, Labs, Dobermans, etc.)
    • Primarily diagnosed in females (6-10 years of age)
    • Results from dysfunction in the hypothalamic-pituitary-thyroid axis, leading to thyroid hormone deficiency
    • More than 95% of cases are due to destruction of the thyroid gland itself (primary hypothyroidism) or thyroid atrophy
    • Autoimmune diseases (like lymphocytic thyroiditis) and idiopathic atrophy are common causes
    • Can cause symptoms like lethargy, weight gain, altered skin/coat (alopecia), excessive shedding, loss of tail hair, sun-seeking behavior, recurrent skin infections, or anestrus

    Hyperthyroid Disease

    • More common in cats (middle-aged to older)
    • Often caused by thyroid adenoma or carcinoma, leading to excess T3 & T4
    • Common clinical signs include weight loss, polyphagia (increased appetite), occasional vomiting, increased appetite, tachycardia, and a murmur
    • Diagnosis is based on increased T4 and TSH levels
    • Treatment options include radioactive iodine-131 (curative)

    Adrenal Glands

    • Outermost zone produces mineralocorticoids (like aldosterone),
    • Middle zone produces glucocorticoids (like cortisol and corticosterone),
    • Inner zone produces sex steroids.

    Addisons Disease (Hypoadrenocorticism)

    • Lack of glucocorticoids, mineralocorticoids, or both
    • Characterized by small size, skinny appearance, and weakness
    • Usually in young to middle-aged dogs (Nova Scotia duck tolling retrievers, Great Danes, Poodles, etc.)

    Cushing's Disease (Hyperadrenocorticism)

    • Elevated cortisol levels due to various causes.
    • Often in middle to older aged dogs (Poodles, especially miniature poodles)
    • Can be pituitary-dependent (PDH) or adrenal-dependent (ADH).
    • Characterized by pot belly, abdominal enlargement, sway back, PU/PD, polyphagia panting, muscle wasting, dermatological changes, Weakness, lethargy and Recurrent UTI's.
    • Diagnosed with low and high-dose dexamethasone suppression tests
    • Treatments include mitotane, trilostane, surgery, and radiotherapy.

    Pancreatitis

    • Inflammation of the pancreas in dogs and cats (acute or chronic, severe and necrotizing)
    • Pancreatic secretions decrease, causing pancreatic enzymes to increase and damage the pancreas.
    • Often associated with high-fat diets, obesity, high cholesterol, high triglycerides, trauma, and tumors.
    • Clinical signs may include nausea, anorexia, vomiting, diarrhea, abdominal pain (praying pose), and weakness.

    Exocrine Pancreatic Insufficiency (EPI)

    • Decreased production of digestive enzymes by the pancreas, resulting in poor absorption of nutrients.
    • Can have genetic component or secondary to chronic pancreatitis
    • Clinical signs include weight loss, normal appetite, diarrhea, pale stools (steatorrhea), and vomiting.
    • Diagnosable with serum trypsin-like immunoreactivity concentrations or assay for fecal elastase.
    • Treatment often includes pancreatic enzyme replacement, cobalamin, and probiotics.

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    Description

    Test your knowledge on endocrine system diseases, focusing on the pancreas and thyroid gland. Explore how hormones affect metabolism and the various diseases that can arise from dysfunction in hormone production. Perfect for students studying veterinary medicine or biology.

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