Endocrine System Quiz
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Questions and Answers

Which hormone is primarily responsible for stimulating the adrenal gland to release corticosteroids?

  • Thyroid stimulating hormone (TSH)
  • Growth hormone (GH)
  • Adrenocorticotrophic hormone (ACTH) (correct)
  • Luteinizing hormone (LH)
  • What is the main function of anti diuretic hormone (ADH)?

  • Regulating metabolism
  • Stimulating growth
  • Stimulating uterine contractions
  • Promoting water retention (correct)
  • Which of the following hormones is released by the anterior pituitary gland?

  • Prolactin-inhibiting hormone
  • Oxytocin
  • Anti diuretic hormone (ADH)
  • Growth hormone (GH) (correct)
  • What impact does growth hormone-inhibiting hormone have on growth hormone secretion?

    <p>It inhibits the secretion of growth hormone (A)</p> Signup and view all the answers

    Which hormone is involved in both ovulation and androgen secretion?

    <p>Luteinizing hormone (LH) (A)</p> Signup and view all the answers

    Which type of feedback mechanism amplifies a signal rather than turning it off?

    <p>Positive feedback (B)</p> Signup and view all the answers

    What type of hormones are produced by neurons and released into the bloodstream?

    <p>Neurohormones (A)</p> Signup and view all the answers

    Which of the following is NOT a method of hormone release?

    <p>Thermal stimulation (A)</p> Signup and view all the answers

    What is the primary function of hormones in the endocrine system?

    <p>To act as chemical signals for distant target sites (A)</p> Signup and view all the answers

    Which of the following is an example of negative feedback in homeostasis?

    <p>Insulin regulating blood sugar levels (A)</p> Signup and view all the answers

    Where are releasing hormones produced?

    <p>Hypothalamus (D)</p> Signup and view all the answers

    What distinguishes neuroendocrine cells from other types of cells?

    <p>They release hormones directly into the bloodstream. (C)</p> Signup and view all the answers

    Which system involves constant monitoring and adjustments to maintain internal balance?

    <p>Homeostatic system (C)</p> Signup and view all the answers

    What is the primary requirement for hormone receptor activation?

    <p>Specific hormones must bind to their receptors. (C)</p> Signup and view all the answers

    Where are receptors for lipophilic hormones typically located?

    <p>In the cytoplasm or nucleus. (A)</p> Signup and view all the answers

    Which type of hormones cannot be stored in vesicles within endocrine cells?

    <p>Steroid hormones. (C)</p> Signup and view all the answers

    Which of the following describes the function of hormone receptor complexes?

    <p>They activate or repress gene expression. (D)</p> Signup and view all the answers

    Which of the following hormones is classified as an amino acid derivative?

    <p>Epinephrine. (A)</p> Signup and view all the answers

    How do hydrophilic hormones primarily act on target cells?

    <p>By binding to extracellular receptors. (D)</p> Signup and view all the answers

    Which functional role is NOT associated with hormones?

    <p>Facilitating digestion in the stomach. (B)</p> Signup and view all the answers

    What categorizes hormones as lipophilic?

    <p>They are derived from cholesterol. (C)</p> Signup and view all the answers

    What role does the hypothalamus play in the endocrine system?

    <p>It regulates the release of hormones from the pituitary gland. (D)</p> Signup and view all the answers

    What is the primary function of the hypophyseal portal system?

    <p>To communicate and transport neurohormones from the hypothalamus to the anterior pituitary. (A)</p> Signup and view all the answers

    Which of the following hormones is NOT produced by the anterior pituitary gland?

    <p>ADH (A)</p> Signup and view all the answers

    What does the release of prolactin (PRL) primarily influence?

    <p>Breast development and milk production. (D)</p> Signup and view all the answers

    What is the primary role of T3 in the body?

    <p>It increases basal metabolism rate (BMR). (A)</p> Signup and view all the answers

    Which hormone is produced by the posterior pituitary gland?

    <p>Oxytocin (A)</p> Signup and view all the answers

    Which hormone is produced in excess during acromegaly?

    <p>Growth hormone (GH) (B)</p> Signup and view all the answers

    Which feedback mechanism primarily regulates hormone release in the endocrine system?

    <p>Both positive and negative feedback. (A)</p> Signup and view all the answers

    What is the function of calcitonin in the body?

    <p>It lowers blood calcium levels. (B)</p> Signup and view all the answers

    What structure beneath the brain houses the pituitary gland?

    <p>Sella turcica. (C)</p> Signup and view all the answers

    Which of the following statements is true regarding T4?

    <p>T4 has a long half-life compared to T3. (A)</p> Signup and view all the answers

    The anterior pituitary is composed of how many distinctive endocrinocytes?

    <p>Six. (A)</p> Signup and view all the answers

    What can result from a deficiency of thyroid hormones during fetal development?

    <p>Damage to the central nervous system (CNS). (A)</p> Signup and view all the answers

    What is the role of parafollicular (C) cells in the thyroid gland?

    <p>They release calcitonin. (A)</p> Signup and view all the answers

    In what condition is a goitre typically observed?

    <p>Hypothyroidism (A)</p> Signup and view all the answers

    How does T4 convert to T3 in the body?

    <p>By enzymatic modification in target cells. (A)</p> Signup and view all the answers

    What is the effect of Vitamin D activation on calcium levels in the body?

    <p>It stimulates the uptake of calcium from the intestine. (C)</p> Signup and view all the answers

    What effect does calcitonin have on calcium levels compared to parathyroid hormone?

    <p>It decreases calcium levels. (C)</p> Signup and view all the answers

    What hormones are produced by the adrenal glands?

    <p>Both corticosteroids and catecholamines. (A)</p> Signup and view all the answers

    What triggers the synthesis of aldosterone?

    <p>A decline in blood volume or blood pressure. (B)</p> Signup and view all the answers

    Where does aldosterone primarily exert its effects in the body?

    <p>On the principal cells of the cortical distal tubules and collecting duct. (B)</p> Signup and view all the answers

    What is the primary action of aldosterone in the kidneys?

    <p>Retention of sodium and water along with secretion of potassium. (B)</p> Signup and view all the answers

    In the activation process of aldosterone, what occurs first?

    <p>Aldosterone binds to a cytoplasmic receptor. (D)</p> Signup and view all the answers

    What might occur if a thyroidectomy unwittingly removes part of the parathyroid glands?

    <p>Decreased calcium levels due to reduced parathyroid hormone. (B)</p> Signup and view all the answers

    Flashcards

    What are hormone receptors, and how do they work?

    Hormones interact with target cells by binding to specific receptors located on the cell surface, in the cytoplasm, or in the nucleus. These receptors are programmed to recognize and bind to specific hormones, triggering a chain of events.

    How do target cells respond to hormones?

    The effect of a hormone on a target cell depends on the cell's programmed response to the hormone. Different cell types may respond differently to the same hormone.

    How do hormones affect gene expression?

    Hormones trigger specific cellular responses by activating or repressing genes within the target cell. This process involves hormone-receptor complexes binding to DNA in the nucleus, acting as transcription factors.

    What are Peptide hormones?

    Peptide hormones are chains of amino acids synthesized on ribosomes of the ER of endocrine cells. They are water-soluble and bind to receptors on the cell surface.

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    What are amino acid derivative hormones?

    Amino acid derivatives are hormones derived from tyrosine or tryptophan. Examples include catecholamines (epinephrine, norepinephrine, dopamine) and thyroid hormones (T4, T3).

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    What are steroid hormones?

    Steroid hormones are lipids derived from cholesterol produced by the gonads, adrenal cortex, and kidneys. They are fat-soluble and bind to intracellular receptors.

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    What are lipophilic hormones?

    Hormones that are lipid-soluble (nonpolar) are called lipophilic. They are fat-soluble and bind to intracellular receptors. Examples include steroid hormones and thyroid hormones.

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    What are hydrophilic hormones?

    Hormones that are water-soluble (polar) are called hydrophilic. They bind to extracellular receptors, such as those found on the cell surface. Most other hormones (except steroid and thyroid) are hydrophilic.

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    What is the anterior pituitary gland's role?

    The anterior pituitary gland produces a diverse range of hormones that regulate key functions related to growth, puberty, stress response, and metabolism.

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    What is the function of Thyroid Stimulating Hormone (TSH)?

    It stimulates the thyroid gland to release thyroid hormones, which are vital in regulating metabolism.

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    What is the function of Adrenocorticotrophic hormone (ACTH)?

    It's responsible for the release of corticosteroids from the adrenal glands, which are vital for managing stress and other bodily functions.

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    What is the function of Luteinizing hormone (LH)?

    It regulates the production of testosterone in men and plays a key role in ovulation in females.

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    What is the role of Gonadotropin-releasing hormone (GnRH)?

    It governs the release of FSH and LH from the anterior pituitary, essential for sex hormone production and reproductive function.

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    Lipid soluble hormones

    Hormones that dissolve in fats and pass through cell membranes to bind to receptors inside the target cell.

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    Homeostasis

    The process of maintaining a stable internal environment in an organism.

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    Negative feedback

    A mechanism where a change in a regulated variable triggers a response that counteracts the initial change, restoring the variable to its set point.

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    Positive feedback

    A mechanism where a change in a regulated variable triggers a response that amplifies the original change, pushing the variable further away from its set point.

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    Neurohormones

    Hormones released by neurons directly into the bloodstream, acting as messengers to distant target cells.

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    Paracrine hormones

    Hormones that are produced in one cell and act on nearby cells.

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    Autocrine hormones

    Hormones that are produced in a cell and act on the same cell that produced it.

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    Primary and secondary endocrine Organs

    The primary endocrine organs produce hormones directly, while secondary endocrine organs produce hormones as a secondary function.

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    Hypothalamus' role in pituitary function

    The hypothalamus, located in the brain, regulates the secretion of hormones from the pituitary gland by releasing its own hormones.

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    What is the role of the pituitary gland?

    The pituitary gland is a small gland located at the base of the brain, considered the 'master gland' because it controls the function of other endocrine glands.

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    What hormones are produced by the anterior pituitary?

    The anterior pituitary gland is responsible for producing and releasing various hormones, including growth hormone (GH), thyroid-stimulating hormone (TSH), and prolactin (PRL).

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    What are the hormones released by the posterior pituitary?

    The posterior pituitary gland doesn't produce hormones, but it stores and releases two hormones: antidiuretic hormone (ADH) and oxytocin. These hormones are produced in the hypothalamus.

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    What is the hypophyseal portal system?

    The hypophyseal portal system is a network of blood vessels that connect the hypothalamus to the anterior pituitary. This system allows the hypothalamus to regulate the release of hormones from the anterior pituitary.

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    How does the hypothalamus control anterior pituitary hormone release?

    The hypothalamus controls the release of anterior pituitary hormones by releasing its own hormones, which act as 'on' or 'off' switches for the anterior pituitary.

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    How is hormone release controlled?

    Positive feedback loops amplify a response, leading to increased secretion of a particular hormone. Negative feedback loops dampen a response, causing a decrease in hormone secretion.

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    How do Hormones work?

    Hormones travel through the bloodstream to reach target cells. Once they reach their targets, they bind to specific receptors, triggering a chain of events that ultimately leads to a specific cellular response.

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    Diabetes Insipidus

    A condition caused by insufficient production of antidiuretic hormone (ADH), leading to excessive water loss in urine and dehydration.

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    Gigantism

    Growth hormone (GH) excess during childhood, resulting in abnormally tall stature.

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    Acromegaly

    Excess growth hormone (GH) secretion in adulthood, causing enlargement of hands, feet, and facial features.

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    Location of the Thyroid Gland

    The thyroid gland is located in the anterior neck, inferior to the larynx.

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    Hormones Produced by the Thyroid

    The thyroid gland produces hormones, primarily T3 and T4 which contain tyrosine and iodine.

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    T3 vs. T4 Potency

    Thyroid hormone T3 is considered more potent than T4, and is responsible for most of its biological effects.

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    Thyroid Hormone Production

    Production of T3 and T4 requires iodine and the interaction of follicle cells and colloid lumen.

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    Function of Calcitonin

    Calcitonin, secreted by parafollicular cells, lowers blood calcium levels by influencing bone and kidney activity.

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    What is aldosterone?

    A steroid hormone produced by the adrenal cortex, aldosterone plays a crucial role in regulating blood volume and blood pressure by promoting sodium reabsorption and potassium secretion in the kidneys.

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    Where does aldosterone act?

    Aldosterone primarily impacts the principal cells of the distal tubules and collecting duct in the kidneys. It increases sodium reabsorption and water reabsorption while promoting potassium secretion.

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    What stimulates aldosterone release?

    Aldosterone secretion is triggered by a decline in blood volume or blood pressure, often due to events like severe hemorrhage. This mechanism helps restore blood pressure and volume to normal levels.

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    How does aldosterone exert its effects?

    Aldosterone combines with a cytoplasmic receptor within the target cells. This hormone-receptor complex initiates transcription in the nucleus, leading to the production of new proteins responsible for sodium and potassium transport.

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    What is the overall impact of aldosterone?

    The net effect of aldosterone action is to retain sodium and water in the body while excreting potassium. This helps maintain blood pressure and volume by adjusting electrolyte balance.

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    What is parathyroid hormone (PTH) and where is it produced?

    Parathyroid hormone (PTH) is a vital hormone that plays a key role in regulating calcium levels in the body. It is secreted by the parathyroid glands, four tiny glands located near the thyroid gland.

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    How does PTH regulate calcium levels?

    PTH increases calcium levels in the blood by stimulating the release of calcium from bones, increasing calcium absorption in the intestines, and reducing calcium excretion in the kidneys.

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    How does PTH compare to calcitonin?

    PTH has the opposite effect on calcium compared to calcitonin, which lowers calcium levels in the blood. They work in a balanced way to ensure proper calcium homeostasis.

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    Study Notes

    The Endocrine System

    • The endocrine system is a system of ductless glands that secrete hormones directly into the bloodstream.
    • It includes organs and tissues that produce and release hormones.
    • Hormones act as chemical messengers, controlling a vast array of physiological processes.
    • Endocrine glands are ductless, comprised of endocrine cells.
    • These glands do not have ducts that lead to the outside of the body.
    • They secrete hormones directly into the bloodstream.
    • Hormones can also act as paracrine or autocrine regulators, affecting nearby or the same cells directly, rather than traveling through the blood.
    • Target cells are cells that contain specific receptors (binding sites) for a particular hormone, allowing the hormone to trigger specific effects.
    • Hormone receptors can be found on the cell's surface, cytoplasm, or nucleus.
    • Hormonal actions are dependent on the programmed response of the target cells.
    • Hormones can affect: fetal development and differentiation; cell growth and cancer; metabolism; cardiovascular function; renal function; skeletal function; reproductive function; immune function; central nervous system function.

    Hormone Classification

    • Hormones are classified into three main categories:
      • Peptide hormones: chains of amino acids, synthesized in ribosomes and stored in vesicles; water-soluble and cannot readily pass through cell membranes.
      • Amino acid derivatives: derived from tyrosine or tryptophan; water-soluble and often controlled by other hormones in the pathway
      • Steroid hormones: derived from cholesterol, lipid-soluble and bind to intracellular receptors.
    • Lipophilic hormones (fat-soluble) include steroid and thyroid hormones, binding to intracellular receptors.
    • Hydrophilic hormones (water-soluble) include peptide and most amino acid-derived hormones, binding to extracellular receptors.

    Types of Hormones

    • Peptide Hormones
      • Composed of chains of amino acids
      • Synthesized in ribosomes; stored in vesicles
      • Not lipid-soluble; receptor located on the cell surface
    • Amino Acid Derivatives
      • Derived from tyrosine or tryptophan
      • Often controlled by other hormones
      • Mostly water-soluble (except thyroid hormones)
    • Steroid Hormones
      • Derived from cholesterol
      • Lipid-soluble; receptors inside the target cell.

    Control of Hormone Release & Homeostasis

    • Homeostasis maintains internal balance and is regulated by constant adjustments in neural and endocrine control (fine regulation).
    • Negative feedback mechanisms turn off a signal to maintain balance in response to changes in body systems.
    • Positive feedback mechanisms amplify a signal in a cycle. Child birth is an example of positive feedback.
    • Hormonal release is controlled by both positive and negative feedback.
    • Humoral stimuli involve changing blood ion levels or nutrients.
    • Neural stimuli involve stimulation by nerves.
    • Hormonal stimuli involve stimulation by other hormones.

    Hypothalamus–Pituitary Axis

    • The hypothalamus and pituitary gland work together as the 'main regulators' of the endocrine system.
    • The hypothalamus releases hormones that either trigger or inhibit the pituitary gland's release of hormones.
    • For example, release of hormones to stimulate the synthesis and secretion of hormones at the anterior pituitary
    • The hypothalamus is part of the brain, controls anterior pituitary activity, and secretes releasing and inhibiting hormones.

    The Pituitary Gland

    • The pituitary gland is pea-sized and sits in a bony hollow below the brain.
    • Called the "master gland," it regulates other endocrine glands via tropic hormones (those that regulate other hormone functions).
    • It is divided into the anterior and posterior pituitary.
    • The anterior pituitary is a true endocrine gland.
    • The posterior pituitary is connected to the hypothalamus and releases hormones produced by the hypothalamus itself.

    The Anterior Pituitary

    • The anterior pituitary contains six major types of endocrine cells.
    • These cells produce and release hormones under the control of hypothalamic hormones. The Hypophyseal Portal System is a communication network connecting the hypothalamus and the anterior pituitary.
    • Examples of anterior pituitary hormones are TSH, ACTH, FSH, LH, PRL, GH.

    The Posterior Pituitary

    • The posterior pituitary is an extension of the hypothalamus.
    • It stores and releases oxytocin and ADH, which are hormones produced by the hypothalamus.
    • Oxytocin is involved in uterine contractions and breast feeding, while ADH regulates water retention.

    The Thyroid Gland

    • Located in the anterior neck, on the trachea
    • The thyroid consists of two lobes, connected by an isthmus.
    • The thyroid produces T3 and T4 (from iodine molecules and tyrosine).
    • Calcitonin regulates calcium and phosphorus metabolism.

    Actions of T3 & T4 and Pathology

    • T3 and T4 are essential for body metabolism (BMR).
    • They increase energy consumption and oxygen.
    • Crucial for fetal (physical and brain) development and skeletal growth.
    • Imbalances, such as hyperthyroidism or hypothyroidism, involve various symptoms and imbalances.

    The Parathyroid Glands

    • Located on the posterior surface of the thyroid gland
    • Contains two types of cells: chief (produce PTH or parathyroid hormone) and oxyphil (function unknown).
    • The parathyroid hormone is essential for regulating calcium levels in the blood and plays a role in calcium homeostasis (opposite to calcitonin).

    The Adrenal Glands

    • Situated on top of the kidneys.
    • Consist of two parts: the outer cortex, which produces a variety of steroid hormones, and the inner medulla, which releases catecholamines (stress hormones such as adrenaline).
    • Mineralcorticoids regulate mineral balance.
    • In the adrenal cortex, glucocorticoids regulate glucose metabolism.

    Cortisol

    • Part of a system crucial for dealing with stress (physical, psychological, or physiological)
    • It keeps blood glucose high enough for brain activity and other body functions.
    • Maintains blood pressure
    • Influences immune responses and inflammatory responses.
    • Cortisol imbalance can lead to Cushing's syndrome or Addison's disease.

    Other important details

    • Neurohormones are neurotransmitters released into the bloodstream to control other organs.

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    Description

    Test your knowledge on the endocrine system and its hormones with this quiz. Explore the functions and mechanisms of various hormones, including their release and regulatory actions. Challenge yourself with questions about hormone feedback and the gland interactions in the body.

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