Endocrine System Quiz
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Questions and Answers

Which of the following is NOT a difference between the endocrine and nervous systems?

  • Type of chemical messengers used (correct)
  • Mode of transport
  • Target tissues
  • Speed of response
  • What type of chemical messenger acts locally on neighboring cells?

  • Autocrine
  • Paracrine (correct)
  • Neurotransmitter
  • Endocrine
  • Which of the following is an example of a hormone that regulates growth and development?

  • Epinephrine
  • Testosterone
  • Insulin
  • Growth hormone (correct)
  • Which of the following best describes the function of exocrine glands?

    <p>Secreting substances onto the surface of the skin or into cavities (D)</p> Signup and view all the answers

    Which of the following best describes the 'amplitude modulated' system of the endocrine system?

    <p>The strength of the signal depends on the concentration of the hormone. (B)</p> Signup and view all the answers

    Which of the following is NOT a physiological process regulated by the endocrine system?

    <p>Immune system function (D)</p> Signup and view all the answers

    What is the role of the hypothalamus in the endocrine system?

    <p>Regulating the activity of the pituitary gland (A)</p> Signup and view all the answers

    Which of the following is an example of a chemical messenger that can act as both a neurotransmitter and a hormone?

    <p>Epinephrine (A)</p> Signup and view all the answers

    What is the most likely cause of a sudden, irregular fluctuation in hormone levels?

    <p>Acute stimulation (D)</p> Signup and view all the answers

    Which of the following is an example of a humoral stimulus for hormone secretion?

    <p>The release of parathyroid hormone (PTH) in response to low blood calcium levels (B)</p> Signup and view all the answers

    Which of the following is a lipid-soluble hormone?

    <p>Testosterone (A)</p> Signup and view all the answers

    What is the half-life of a hormone?

    <p>The time it takes for 50% of a hormone to be removed from circulation (B)</p> Signup and view all the answers

    Which of the following is NOT a mechanism for maintaining blood hormone levels?

    <p>Hormone synthesis by the target cells (D)</p> Signup and view all the answers

    Which type of receptor is typically used by water-soluble hormones?

    <p>Membrane-bound receptors (D)</p> Signup and view all the answers

    Which of the following is NOT a mechanism used by membrane-bound receptors to initiate a cellular response?

    <p>Direct gene activation (D)</p> Signup and view all the answers

    Which of the following is a characteristic of nuclear receptors?

    <p>They directly activate gene transcription (D)</p> Signup and view all the answers

    What is the primary mechanism by which a target cell can decrease its sensitivity to a hormone?

    <p>Down-regulation of receptors (B)</p> Signup and view all the answers

    What is an agonist?

    <p>A drug that mimics the action of a hormone by binding to its receptor (D)</p> Signup and view all the answers

    Which type of interaction between hormones results in a stronger response than either hormone acting alone?

    <p>Synergistic (B)</p> Signup and view all the answers

    Which of the following is NOT a component of the pituitary gland?

    <p>Hypothalamus (B)</p> Signup and view all the answers

    Which part of the pituitary gland is considered to be nervous tissue?

    <p>Posterior pituitary (C)</p> Signup and view all the answers

    What is the primary connection between the hypothalamus and the anterior pituitary gland?

    <p>Vascular connection (D)</p> Signup and view all the answers

    What triggers the secretion of calcitonin?

    <p>High blood calcium levels (C)</p> Signup and view all the answers

    What is the primary effect of parathyroid hormone (PTH)?

    <p>Raise blood calcium and phosphate levels (D)</p> Signup and view all the answers

    Which structure is primarily responsible for the secretion of glucagon?

    <p>Alpha cells (D)</p> Signup and view all the answers

    What condition is characterized by a hypersecretion of parathyroid hormone?

    <p>Hypercalcemia (C)</p> Signup and view all the answers

    Which layer of the adrenal cortex is responsible for the secretion of aldosterone?

    <p>Zona glomerulosa (C)</p> Signup and view all the answers

    What is a common characteristic of hyperparathyroidism?

    <p>Kidney stones (B)</p> Signup and view all the answers

    Which of the following hormones acts to lower blood glucose levels after a meal?

    <p>Insulin (A)</p> Signup and view all the answers

    What is one of the effects of adrenal medulla hormones during physical activity?

    <p>Increase breakdown of liver glycogen (A)</p> Signup and view all the answers

    Which type of tissues do catecholamines bind to for their effects?

    <p>Adrenergic receptor sites (B)</p> Signup and view all the answers

    What is a potential symptom of hypoparathyroidism?

    <p>Diarrhea (A)</p> Signup and view all the answers

    Which of the following is NOT a hormone produced by the anterior pituitary gland?

    <p>Antidiuretic hormone (ADH) (C)</p> Signup and view all the answers

    Which hormone is responsible for stimulating the release of cortisol from the adrenal cortex?

    <p>Adrenocorticotropic hormone (ACTH) (C)</p> Signup and view all the answers

    What is the primary function of the hypothalamohypophysial portal system?

    <p>To transport hormones from the hypothalamus to the anterior pituitary gland (B)</p> Signup and view all the answers

    Which of the following hormones is responsible for stimulating the production of milk in the mammary glands?

    <p>Prolactin (D)</p> Signup and view all the answers

    Which hormone is released from the posterior pituitary gland and helps regulate blood pressure by constricting blood vessels?

    <p>Antidiuretic hormone (ADH) (D)</p> Signup and view all the answers

    Which of the following statements is TRUE regarding the synthesis and secretion of thyroid hormones?

    <p>Thyroid hormones (T3 and T4) require iodine and tyrosine for their synthesis. (B)</p> Signup and view all the answers

    Which of the following conditions results from chronic hyposecretion of growth hormone during childhood?

    <p>Pituitary dwarfism (D)</p> Signup and view all the answers

    What is the main function of the thyroid hormone?

    <p>Increasing basal metabolic rate (B)</p> Signup and view all the answers

    Which hormone is involved in stimulating uterine contractions during labor?

    <p>Oxytocin (B)</p> Signup and view all the answers

    Which of the following hormones is considered a tropic hormone?

    <p>Thyroid-stimulating hormone (TSH) (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the stress response?

    <p>Increased secretion of insulin (D)</p> Signup and view all the answers

    Which of the following is an example of a negative feedback loop in hormone regulation?

    <p>The release of thyroid hormone in response to TSH (A)</p> Signup and view all the answers

    Which of the following hormones is responsible for regulating blood calcium levels?

    <p>Parathyroid hormone (PTH) (A)</p> Signup and view all the answers

    What is the main difference between short-term and long-term stress responses?

    <p>Short-term stress responses are mediated by the sympathetic nervous system, while long-term stress responses are mediated by the endocrine system. (B)</p> Signup and view all the answers

    Which of the following is a characteristic of a goiter?

    <p>Enlargement of the thyroid gland (D)</p> Signup and view all the answers

    What is the structural type of the hormone GnRH?

    <p>Small peptide (B)</p> Signup and view all the answers

    What type of receptor do TSH receptors use?

    <p>G protein-coupled receptors (D)</p> Signup and view all the answers

    Flashcards

    Hormone

    Chemical messengers secreted by endocrine organs into the blood.

    Target Tissue

    Tissues that hormones affect to elicit a change.

    Endocrine Glands

    Glands that secrete substances into the bloodstream.

    Exocrine Glands

    Glands that secrete substances onto surfaces rather than into blood.

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    Nervous System

    A system that transmits signals quickly using neurons.

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    Endocrine System

    A system that uses hormones to regulate processes over time.

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    Autocrine Messengers

    Substances secreted by a cell that affect the same cell.

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    Paracrine Messengers

    Substances secreted into the extracellular fluid affecting nearby cells.

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    Chronic Stimulation

    Constant hormone concentration over a long period.

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    Acute Stimulation

    Sudden and irregular changes in hormone levels.

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    Episodic Stimulation

    Hormones secreted in predictable patterns.

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    Humoral Stimuli

    Hormone release triggered by changes in blood chemical levels.

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    Neural Stimuli

    Hormone release initiated by neurotransmitters from neurons.

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    Hormonal Stimuli

    Hormones secreted in response to other hormones.

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    Lipid Soluble Hormones

    Hormones that require binding proteins to transport in blood.

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    Water Soluble Hormones

    Polar hormones that need assistance to enter cells.

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    Half-life

    Time it takes for 50% of a hormone to be removed from circulation.

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    Membrane Bound Receptors

    Receptors for water soluble hormones located on cell membranes.

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    Nuclear Receptors

    Receptors for lipid soluble hormones that activate transcription.

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    Up Regulation

    Increasing receptor numbers to enhance sensitivity to a hormone.

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    Down Regulation

    Decreasing receptor numbers, leading to reduced sensitivity.

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    Permissive Interactions

    One hormone enhances the effect of another for a stronger reaction.

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    Antagonistic Interactions

    Hormones that work against each other to regulate responses.

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    Hypothalamus-Pituitary Connection

    The hypothalamus and pituitary gland are connected via the infundibulum.

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    Hypothalamic Hormones

    Hormones produced in hypothalamic neurons, stored in the posterior pituitary.

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    GHRH

    Growth hormone-releasing hormone; a peptide that stimulates GH secretion from anterior pituitary.

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    GHIH

    Growth hormone-inhibiting hormone; small peptide that decreases GH secretion.

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    TRH

    Thyrotropin-releasing hormone; a small peptide that increases TSH secretion.

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    ACTH

    Adrenocorticotropic hormone; stimulates cortisol release to regulate stress.

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    ADH

    Antidiuretic hormone; conserves water in body by acting on kidneys.

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    Oxytocin

    Hormone stimulating uterine contractions; important in childbirth.

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    Tropic Hormones

    Hormones that influence the release of other hormones.

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    GH Effects

    Growth hormone promotes tissue growth, amino acid uptake, and protein synthesis.

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    Thyroid Gland Structure

    Composed of follicular and parafollicular cells, highly vascular.

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    T3 and T4 Synthesis

    Produced in follicular cells using iodine and tyrosine.

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    T3 and T4 Regulation

    Secretion regulated by TSH and TRH, with negative feedback from T3 and T4.

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    Thyroid Hormone Effects

    Increases basal metabolic rate, activity of NaK pumps, and ATP production.

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    Hypothyroidism

    A condition characterized by low levels of thyroid hormones (T3 and T4), leading to elevated TSH and potential goiter.

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    Hyperthyroidism

    A condition with excessive thyroid hormones, often due to autoimmune diseases like Graves Disease, leading to hypersecretion of TSH.

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    Calcitonin

    A hormone produced by parafollicular cells that lowers blood calcium levels by reducing osteoclast activity and promoting bone deposition.

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    Parathyroid Glands

    Four glands located at the posterior of the thyroid, consisting mainly of chief cells that secrete parathyroid hormone (PTH).

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    Parathyroid Hormone (PTH)

    Hormone released when blood calcium is low, raises levels through bone resorption and kidney calcium reabsorption.

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    Hypoparathyroidism Symptoms

    Results in low calcium levels (hypocalcemia), leading to neuromuscular excitation, including tetany and cardiac arrhythmia.

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    Hyperparathyroidism Symptoms

    Elevated calcium (hypercalcemia) leads to muscle weakness, osteoporosis, and increased risk of kidney stones.

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    Adrenal Medulla Hormones

    Secretes epinephrine (80%) and norepinephrine (20%) to prepare the body for physical activity by increasing glucose and heart rate.

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    Adrenal Cortex Zones

    Three layers: Zona glomerulosa (mineralocorticoids), Zona fasciculata (glucocorticoids), Zona reticularis (androgens), each secreting specific hormones.

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    Pancreatic Islet Hormones

    Insulin lowers blood glucose; glucagon raises it, secreted by alpha and beta cells in the pancreatic islets.

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    Study Notes

    Endocrine System Study Notes

    • Hormones are chemical messengers secreted into the bloodstream by endocrine organs, targeting effector cells (target tissues) to elicit responses.
    • Endocrine glands secrete hormones into the bloodstream or locally, while exocrine glands secrete substances onto body surfaces.

    Nervous vs. Endocrine Systems

    • Similarities:
      • Share some brain structures (e.g., hypothalamus)
      • Utilize some chemical messengers—neurotransmitters and hormones (e.g., epinephrine has both nervous system and endocrine functions)
      • Both utilize G protein-coupled receptors for water-soluble hormones.
    • Differences:
      • Mode of transport:
        • Nervous: releases neurotransmitters directly onto target cells via axons.
        • Endocrine: releases hormones into the bloodstream for distant target tissues.
      • Speed of response:
        • Nervous: fast (milliseconds), frequency-modulated (action potential frequency determines signal strength).
        • Endocrine: slower (minutes to days), amplitude-modulated (hormone concentration determines signal strength).
      • Signal strength:
        • Nervous: all action potentials are the same size; signal strength depends solely on frequency.
        • Endocrine: signal strength varies with hormone concentration.

    Physiological Processes Regulated by Endocrine System

    • Growth and Development: Growth hormone influences nerve, bone and muscle growth.
    • Metabolism: Regulates nutrient uptake/release (e.g. heart rate, respiration).
    • Blood Composition: Regulates blood cell production.
    • Reproduction: Influences sexual development and reproductive function.

    Chemical Messengers

    • Autocrine: Affects the same cell that secreted it. Example eicosanoids
    • Paracrine: Affects nearby cells. Examples: somatostatin, histamines (common in digestive and urinary systems).
    • Neurotransmitter: Affects post-synaptic cells after traveling short distances. Examples: acetylcholine, epinephrine.
    • Endocrine: Secreted into the bloodstream to affect distant targets. Examples: thyroid hormones, growth hormone, insulin, epinephrine, estrogen, progesterone, and testosterone.

    Stimulatory Influences on Hormone Secretion

    • Chronic: Constant low-amplitude secretion over long periods. Example: Thyroid hormone.
    • Acute: Sudden and irregular changes in concentration. Example: Epinephrine (stress response).
    • Episodic (cyclic): Predictable patterns of hormone secretion. Example: Female reproductive hormones (menstrual cycle).

    Patterns of Hormone Secretion

    • Humoral stimuli: Release triggered by changes in blood plasma levels of certain substances (e.g., calcium). PTH and calcitonin regulate blood calcium levels
    • Neural stimuli: Initiated by neuron stimulation; neurotransmitters affect endocrine cells to elicit a hormonal response. Examples include epinephrine and norepinephrine.
    • Hormonal stimuli: Hormones released in response to other hormones (often tropic hormones). Anterior pituitary hormones frequently regulate other hormones in a cascading effect

    Hormone Classes

    • Lipid-soluble hormones: (Steroid, some amino acid derivatives, fatty acid derivatives).
      • Travels with carrier proteins in blood.
      • Enters target cells directly.
      • Examples include testosterone, aldosterone, T4 (thyroid hormone).
    • Water-soluble hormones: (Proteins, peptides, amino-acid-based hormones)
      • Travels freely in blood.
      • Binds to membrane receptors, initiating a second messenger system.
      • Examples include TSH, GH, insulin, epinephrine, norepinephrine.

    Hormone Stability and Transport

    • Chemical nature strongly influences a hormone's half-life and transport method (lipid-soluble vs. water-soluble). Larger, more complex hormones are more stable and degraded more slowly, in large part due to binding proteins.

    Maintaining Blood Hormone Levels

    • Degradation: Hormones are broken down in circulation and by enzymes
      • Lipid-soluble hormones can diffuse from capillaries, degrade through liver/lung enzymes, or be filtered by the kidneys.
      • Water-soluble hormones are broken down by blood proteases, and eliminated by the kidneys.
    • Half-life: The time it takes for 50% of hormone to be removed from the blood.

    Hormone Receptor Mechanisms

    • Membrane-bound receptors: Used by water-soluble hormones.
      • Activation results in cellular response via second messenger system (e.g., cAMP, calcium).
      • Types include ligand-gated ion channels; G-protein-coupled receptors and enzymatic receptors.
    • Nuclear receptors: Used by lipid-soluble hormones for direct gene activation.

    Target Cell Sensitivity

    • Concentration, receptor number and affinity, and hormone-receptor complex all determine the target cell's response to a hormone.
    • Downregulation: Decreasing receptor numbers (less sensitive)
    • Upregulation: Increasing receptor numbers (more sensitive)

    Hormone Interactions

    • Permissive: One hormone enhances the effect of another (i.e. one hormone is needed to allow the other to work).
    • Synergistic: Multiple hormones act together to produce a result greater than the sum of their individual effects.
    • Antagonistic: Hormones have opposing effects on the same target cell.

    Second Messenger Systems

    • Utilize membrane bound receptors to alter a target cell's activities. The binding of a hormone to a surface receptor activates a cascade of intracellular second messengers within the cell, eliciting a response.

    Pituitary Gland

    • Located in sella turcica of the sphenoid bone.
    • Composed of posterior (neurohypophysis), and anterior (adenohypophysis) lobes.
    • Connected to hypothalamus via infundibulum, with physical, neural, and vascular connections.

    Hypothalamic Regulation of Pituitary Hormone Secretion

    • Hypothalamus regulates anterior pituitary via releasing and inhibiting hormones.
    • Hormones from the posterior pituitary are made and stored in the hypothalamus in nerve cells and then released via axons.

    Hypothalamic Hormones

    (Note: structural type, target tissues, and actions are highly detailed and are summarized here):

    • Vary in structure (peptides, amino acid derivatives).
    • Target anterior pituitary cells to influence release of anterior pituitary hormones.

    Anterior Pituitary Hormones

    (Note: structural type, target tissues, and actions are highly detailed and are summarized here):

    • GH, Prolactin, TSH, ACTH, Lipotropins, Gonadotropins (LH, FSH).
    • Various structures (peptides, proteins).
    • Target various tissues.
      • Have effects on metabolism, growth, stress response, and reproduction, and include feedback mechanisms.

    Posterior Pituitary Hormones

    • ADH (vasopressin), Oxytocin.
      • Both act in response to specific stimuli to control fluid balance, contractions during childbirth, and milk ejection. Both derived in the hypothalamus

    Tropic Hormones

    • Hormones that regulate the release of other hormones.

    Pituitary Hormone Disorders

    • Over or under-secretion of pituitary hormones can result in disorders (e.g., dwarfism, gigantism, acromegaly).

    Stress Hormones

    Thyroid Gland

    • Consists of follicular and parafollicular cells.
    • Stores high concentrations of hormones (thyroglobulin).

    Thyroid Hormone Synthesis and Secretion

    • Involves iodine uptake, coupling of iodinated tyrosine molecules.
    • Negative feedback loop regulating thyroid hormone production
      • TSH and TRH regulated by negative feedback from T3 and T4
    • Synthesized from amino acids.

    Thyroid Hormone Action and Effects

    • Primary purpose is to increase basal metabolic rate (BMR).
    • Key effects include increased body temperature, sodium-potassium pump activity, and mitochondrial activity.

    Adrenal Glands

    • Composed of medulla and cortex.

    Adrenal Medulla Hormones

    • Primarily epinephrine and norepinephrine.
    • Actions include preparing the body for "fight or flight" response (e.g., increased heart rate, blood pressure).
    • Related to the sympathetic nervous system.

    Adrenal Cortex Layers and Hormones

    • Zona glomerulosa: Mineralocorticoids (aldosterone): regulates electrolytes and blood pressure
    • Zona fasciculata: Glucocorticoids (cortisol): regulates metabolism and immune response, stress response
    • Zona reticularis: Androgens: affect sexual development and function.

    Pancreas

    • Pancreatic islets (islets of Langerhans) contain endocrine cells (alpha, beta, delta).

    Pancreatic Hormones

    • Insulin: Lowers blood glucose levels
    • Glucagon: Raises blood glucose levels
    • Somatostatin: Inhibits secretion of other pancreatic hormones.

    Diabetes Mellitus

    • Type 1: Autoimmune destruction of beta cells, requiring insulin injections.
    • Type 2: Insulin resistance, often due to lifestyle factors, often managed with diet and exercise.

    Exercise and Energy Regulation

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    Description

    Test your knowledge of the endocrine system with this quiz. It covers topics such as hormone functions, types of chemical messengers, and the role of glands. Perfect for students looking to deepen their understanding of human physiology.

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