Endocrine System Overview Quiz

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Questions and Answers

Which of the following best describes the function of a gland?

  • To transport oxygen throughout the body
  • To secrete chemical substances for use in the body or for discharge (correct)
  • To provide structural support to the body
  • To filter blood and remove waste products

Which type of gland releases its products directly into the bloodstream?

  • Salivary gland
  • Endocrine gland (correct)
  • Exocrine gland
  • Heterocrine gland

Which of these is an example of a heterocrine gland?

  • Adrenal gland
  • Pancreas (correct)
  • Thyroid gland
  • Sweat gland

What is the primary function of the pineal gland?

<p>Regulating sleep cycles through melatonin production (A)</p> Signup and view all the answers

Which of the following is NOT a role of the hypothalamus?

<p>Producing digestive enzymes (D)</p> Signup and view all the answers

What is the role of Corticotropin-releasing hormone (CRH)?

<p>Signals the pituitary gland to make adrenocorticotrophic hormone (ACTH) (C)</p> Signup and view all the answers

Where are Anti-Diuretic Hormone (ADH) and Oxytocin stored before being released?

<p>In the posterior pituitary gland (B)</p> Signup and view all the answers

What is the effect of Anti-Diuretic Hormone (ADH) on the body?

<p>It narrows blood vessels and increases blood pressure (A)</p> Signup and view all the answers

What is the primary function of the antidiuretic hormone (ADH)?

<p>Conserving water by targeting the kidneys (D)</p> Signup and view all the answers

Which hormone is known for stimulating the thyroid gland to produce T3 and T4?

<p>Thyroid-stimulating hormone (TSH) (B)</p> Signup and view all the answers

Which of these hormones plays a key role in the development of the mammary gland and milk synthesis?

<p>Prolactin (A)</p> Signup and view all the answers

Which hormone stimulates the contraction of both mammary gland and the uterus?

<p>Oxytocin (B)</p> Signup and view all the answers

What is the primary function of calcitonin?

<p>Decreases blood calcium levels by inhibiting osteoclasts (C)</p> Signup and view all the answers

Which of the following is stimulated by biological stress and increases the production and release of corticosteroids such as cortisol?

<p>Adrenocorticotrophic hormone (ACTH) (B)</p> Signup and view all the answers

What can result from hyperthyroidism?

<p>Protruding eyes and nervousness (A)</p> Signup and view all the answers

Which of the following is a symptom commonly associated with hypothyroidism?

<p>Tiredness (D)</p> Signup and view all the answers

Elevated levels of CA15-3 are most commonly associated with which condition?

<p>Metastatic breast cancer (B)</p> Signup and view all the answers

Which of the following is the typical reference range for serum Ferritin levels in adult females?

<p>5-148 ng/ml (C)</p> Signup and view all the answers

During the ovulatory surge, what is the expected range for Luteinizing Hormone (LH) levels in women?

<p>25-100 mIU/mL (D)</p> Signup and view all the answers

Which of the following represents the upper limit for a normal serum level of Total Prostate-Specific Antigen (T.PSA) in men?

<p>4 ng/ml (B)</p> Signup and view all the answers

What is the normal range for serum cortisol levels in the AM?

<p>5-25 mcg/dL (C)</p> Signup and view all the answers

What is the primary function of aldosterone?

<p>To increase the reabsorption of sodium and water in the kidneys, and decrease potassium secretion. (C)</p> Signup and view all the answers

Which hormone directly stimulates the breakdown of bone matrix when blood calcium levels are low?

<p>Parathyroid hormone (PTH) (D)</p> Signup and view all the answers

What is the role of glucagon in glucose regulation?

<p>To increase blood glucose levels by breaking down glycogen (C)</p> Signup and view all the answers

Which hormone is primarily responsible for regulating the sleep/wake cycle?

<p>Cortisol (B)</p> Signup and view all the answers

What is the function of ferritin?

<p>To store iron inside cells (A)</p> Signup and view all the answers

Which vitamin is essential for the development of the brain, nerves, and blood cells?

<p>Vitamin B12 (D)</p> Signup and view all the answers

What is the main function of thymosin?

<p>To stimulate T cell production (C)</p> Signup and view all the answers

Which of the following is NOT a function of cortisol?

<p>Decreases the breakdown of fats and proteins. (D)</p> Signup and view all the answers

Which of the following is NOT a function of Vitamin D in the human body?

<p>Enhancing red blood cell production (D)</p> Signup and view all the answers

Which tumor marker is primarily associated with liver cancer?

<p>AFP (D)</p> Signup and view all the answers

Elevated levels of Beta-human chorionic gonadotropin (ß-HCG) are typically indicative of which condition in men?

<p>Testicular cancer (D)</p> Signup and view all the answers

An increase in the levels of Calcitonin in the blood is most closely associated with which type of cancer?

<p>Medullary thyroid cancer (D)</p> Signup and view all the answers

For which condition would elevated levels of Carbohydrate Antigen 125 (CA-125) most likely be checked?

<p>Gynecologic diseases, including ovarian cancer (C)</p> Signup and view all the answers

Which tumor marker is commonly elevated in people with digestive tract cancers, particularly pancreatic cancer?

<p>CA 19-9 (A)</p> Signup and view all the answers

Which tumor marker is commonly assessed when evaluating a patient for possible prostate cancer?

<p>Prostate-specific antigen (PSA) (B)</p> Signup and view all the answers

Which tumor marker is associated with both breast cancer and is also a protein that can be measured in the blood?

<p>CA 15.3 (A)</p> Signup and view all the answers

Flashcards

Endocrine glands

Glands that secrete their products, hormones, directly into the blood.

Exocrine glands

Glands that secrete their products through ducts into specific locations.

Heterocrine glands

Glands that perform both exocrine and endocrine functions.

Pineal gland

A small gland located in the brain that regulates sleep through the production of melatonin.

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Hypothalamus

A region of the brain that controls various bodily functions like body temperature, blood pressure, and heart rate. It also plays a crucial role in releasing hormones.

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Corticotropin-releasing hormone (CRH)

A hormone released by the hypothalamus that signals the pituitary gland to produce adrenocorticotrophic hormone (ACTH).

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Thyrotropin-releasing hormone (TRH)

A hormone released by the hypothalamus that signals the pituitary gland to produce thyroid stimulating hormone (TSH).

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Growth Hormone Releasing Hormone

A hormone released by the hypothalamus that signals the pituitary gland to produce growth hormone (GH).

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What is CA15-3?

A tumor marker, elevated in most women with breast cancer that has spread to other parts of the body (metastatic breast cancer). CA15-3 levels rise when cancer cells over-produce the antigen. However, not all breast cancer types cause CA15-3 levels to rise due to variations in cancer cell behavior.

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What is CA125?

A tumor marker often elevated in women with ovarian cancer. Elevated levels of CA125 in the blood can be a sign of ovarian cancer.

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What is CA19-9?

A tumor marker found in blood that may indicate pancreatic cancer, colorectal cancer, and other cancers. Levels may also be elevated in certain non-cancerous conditions such as pancreatitis or liver disease.

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What is Alpha-fetoprotein (AFP)?

A protein found in the blood that can help detect certain types of liver cancer, known as hepatocellular carcinoma. It's also found in other medical conditions including viral hepatitis, cirrhosis, and alcoholism.

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What is Carcinoembryonic antigen (CEA)?

A protein found in the blood that can help detect colorectal cancer in some cases. The level of CEA can also be elevated in smokers and in other conditions such as ulcerative colitis and Crohn's disease.

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Parathyroid hormone (PTH)

A hormone that regulates blood calcium levels by stimulating osteoclast activity, promoting calcium reabsorption in kidneys, and decreasing calcium excretion in urine.

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Adrenal Cortex

The outer portion of the adrenal gland, responsible for producing hormones like aldosterone and cortisol.

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Aldosterone

A mineralocorticoid hormone produced by the adrenal cortex, responsible for regulating sodium and potassium levels in the body.

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Cortisol

A glucocorticoid hormone produced by the adrenal cortex, plays a crucial role in regulating blood glucose levels, managing stress responses, and controlling inflammation.

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Insulin

A hormone produced by the pancreas, plays a key role in regulating blood glucose levels by promoting glucose uptake and storage in the liver, skeletal muscles, and adipose tissue.

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Glucagon

A hormone produced by the pancreas, counteracts the effects of insulin by increasing blood glucose levels by promoting glycogen breakdown in the liver.

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Ferritin

A protein found inside cells, responsible for storing iron. Iron is essential for producing red blood cells, which carry oxygen throughout the body.

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Vitamin B12

An essential vitamin found in foods like meat, fish, and dairy products. It is crucial for the function and development of the brain, nerves, and blood cells.

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What is the pituitary gland?

The pituitary gland is a small gland located in the brain, responsible for producing and releasing various hormones that regulate many bodily functions.

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How is the pituitary gland structured?

The pituitary gland is divided into two main sections: the anterior lobe and the posterior lobe, each responsible for producing and releasing different hormones.

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What hormones are produced by the anterior lobe?

The anterior lobe of the pituitary gland produces and releases growth hormone (GH), prolactin, thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), and adrenocorticotropic hormone (ACTH).

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What is the function of growth hormone (GH)?

Growth hormone (GH) stimulates the growth of bones, cartilage, and connective tissues, contributing to overall body development.

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What is the function of prolactin?

Prolactin plays a crucial role in the development of the mammary glands and the production of milk.

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What is the function of thyroid-stimulating hormone (TSH)?

Thyroid-stimulating hormone (TSH) stimulates the thyroid gland to produce thyroid hormones, which regulate metabolism.

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What hormones are released by the posterior lobe?

The posterior lobe of the pituitary gland releases anti-diuretic hormone (ADH) and oxytocin.

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What is the function of anti-diuretic hormone (ADH)?

Anti-diuretic hormone (ADH) helps conserve water by regulating its reabsorption in the kidneys.

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What is the function of oxytocin?

Oxytocin, often called the "love hormone", stimulates uterine contractions during childbirth and milk ejection from the mammary glands.

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What are the roles of vitamin D in the body?

Vitamin D is essential for strong bones and teeth, supports the immune system, brain, and nervous system, regulates insulin levels, aids in diabetes management, supports lung function and cardiovascular health, and plays a role in gene expression related to cancer development.

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What are tumor markers?

Tumor markers are substances, often proteins, produced in higher amounts by cancer cells compared to normal cells. They can be found in various bodily fluids like blood, urine, and stool, and may be used to detect cancer or monitor its progression.

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What is Alpha-fetoprotein (AFP) and how is it related to cancer?

Alpha-fetoprotein (AFP) is a protein elevated in the blood of individuals with liver cancer (hepatocellular carcinoma), and may also be elevated in certain ovarian or testicular cancers.

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What is Beta-human chorionic gonadotropin (ß-HCG) and how is it related to cancer?

Beta-human chorionic gonadotropin (ß-HCG) is a hormone primarily produced during pregnancy. However, elevated levels can also indicate cancers originating in the placenta (women) or testicular cancer (men).

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What is Beta2 (ß2)-microglobulin and how is it related to cancer?

Beta2 (ß2)-microglobulin is a protein that can be elevated in individuals with multiple myeloma or certain lymphomas.

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What is Calcitonin and how is it related to cancer?

Calcitonin is a hormone produced by C cells in the thyroid gland. Elevated levels in the blood can indicate medullary thyroid cancer.

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What is Carbohydrate antigen 125 (CA-125) and how is it related to cancer?

Carbohydrate antigen 125 (CA-125) is a protein that can be elevated in women with various gynecologic conditions, including ovarian cancer, but also some benign conditions.

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What is Carbohydrate antigen 19-9 (CA 19-9) and how is it related to cancer?

Carbohydrate antigen 19-9 (CA 19-9) is a protein often elevated in people with cancers of the digestive tract, particularly pancreatic cancer.

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Study Notes

Glands

  • A gland is an organ that secretes specific chemical substances for use within the body or for release into the surrounding area.
  • Three types of glands exist: endocrine, exocrine, and heterocrine.

Exocrine Glands

  • Exocrine glands secrete their products into ducts.
  • Examples include sweat glands, salivary glands, mammary glands, stomach, and liver (the largest gland).

Endocrine Glands

  • Endocrine glands secrete their products (hormones) directly into the bloodstream.
  • Examples include the pituitary gland, thyroid gland, and adrenal gland.

Heterocrine Glands

  • Heterocrine glands perform both exocrine and endocrine functions.
  • The pancreas is an example.

Endocrine System

  • The endocrine system is a complex network of glands and organs that produce and release hormones into the bloodstream to regulate various bodily functions.

Pineal Gland

  • The smallest gland.
  • Produces melatonin.
  • Regulates sleep.

Hypothalamus

  • A small region of the brain.
  • Controls body temperature, blood pressure, and heart rate.
  • Releases hormones that control other glands.

Hypothalamus Hormones

  • Corticotropin-releasing hormone (CRH) signals the pituitary gland to produce adrenocorticotropic hormone (ACTH).
  • Thyrotropin-releasing hormone (TRH) signals the pituitary to make thyroid-stimulating hormone (TSH).
  • Gonadotropin-releasing hormone (GnRH) signals the pituitary to produce follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
  • Growth hormone-releasing hormone signals the pituitary to produce growth hormone (GH).
  • Somatostatin signals the pituitary to produce less growth hormone (GH).
  • Anti-diuretic hormone (ADH) signals the kidneys to conserve water and constricts blood vessels, increasing blood pressure.
  • Oxytocin helps the uterus contract and is important for breastfeeding.

Pituitary Gland

  • A small gland in the brain controlled by the hypothalamus.
  • Divided into anterior and posterior lobes.
  • Secretes at least six hormones.

Pituitary Gland Hormones (Anterior Lobe)

  • Growth hormone (GH): Stimulates growth of bones, cartilage, and connective tissue.
  • Prolactin: Important for mammary gland development and milk production.
  • Thyroid-stimulating hormone (TSH): Stimulates the thyroid gland to produce T3 and T4 hormones.
  • Follicle-stimulating hormone (FSH): Stimulates the development and maturation of reproductive processes.
  • Luteinizing hormone (LH): Stimulates the production of androgens in the gonads (testes and ovaries).
  • Adrenocorticotropic hormone (ACTH): Stimulates the adrenal cortex to produce corticosteroids.

Pituitary Gland Hormones (Posterior Lobe)

  • Antidiuretic hormone (ADH): Conserves water in the kidneys.
  • Oxytocin: Stimulates uterine contractions and milk production.

Thyroid Gland

  • One of the largest glands in the body.
  • Requires iodine to function.
  • Produces thyroid hormones T4 and T3, which regulate metabolic rates.

Thyroid Disorders

  • Hyperthyroidism: Can lead to Graves' disease with symptoms like sweating, rapid heartbeat, weight loss, and nervousness.
  • Hypothyroidism: Symptoms include tiredness, weight gain, and slow metabolism.
  • Hashimoto's Thyroiditis: An autoimmune disorder causing inflammation of the thyroid gland.
  • Thyroid Tumors: Can cause an overproduction of thyroid hormones.

Thyroid Hormones

  • Calcitonin: Produced by C-cells in the thyroid gland; regulates calcium levels in the blood by inhibiting osteoclast activity and decreasing calcium absorption in the kidneys.
  • Inhibitory feedback mechanisms regulate the production of thyroid hormones.

Parathyroid Gland

  • The parathyroid hormone (PTH) regulates blood calcium levels.
  • If calcium levels are low, osteoclasts break down bone to release calcium and reduce calcium loss in urine.

Adrenal Gland

  • Located on the kidneys.
  • Composed of two regions: medulla and cortex.

Adrenal Medulla

  • Releases epinephrine and norepinephrine (adrenaline and noradrenaline) in response to stress and physical activity.
  • Increases heart rate, blood pressure, and metabolic rate in skeletal muscles.

Adrenal Cortex

  • Releases aldosterone, a mineralocorticoid regulating sodium and potassium levels, indirectly influencing blood pressure and blood volume.
  • Releases cortisol, a glucocorticoid increasing blood sugar, regulating the sleep-wake cycle, and influencing inflammatory and immune responses.

Pancreas

  • An organ in the abdomen.
  • Insulin regulates blood glucose levels after meals by storing extra glucose as glycogen.
  • Glucagon regulates blood glucose levels between meals by breaking down glycogen into glucose.

Thymus Gland

  • Produces thymosin, a hormone stimulating T cell production.

Anemia Profile

  • Ferritin: A protein that stores iron for use in red blood cells production.
  • Vitamin B12: Essential for the production of healthy red blood cells and the functioning of the brain, nerves, and other organs.
  • Folate: A B-vitamin important for cell division and the formation of red blood cells.

Vitamin D

  • Fat-soluble vitamin produced in the skin when exposed to sunlight.
  • Important for bone health, immune function, and other bodily processes.

Tumor Markers

  • Substances like proteins produced in higher amounts by cancer cells compared to normal cells.
  • Used in diagnosing and monitoring cancer.
  • examples like alpha-fetoprotein (AFP), beta-human chorionic gonadotropin (B-HCG), betaâ‚‚-microglobulin, calcitonin, carbohydrate antigen 125 (CA-125), and carbohydrate antigen 19-9 (CA 19-9). Also Carcinoembryonic antigen (CEA) and Prostate-specific antigen (PSA) and thyroglobulin and CA-15-3

Normal Range of Hormones

  • Ranges of various hormones to be used for analysis and comparison of data for testing purposes.

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