Podcast
Questions and Answers
What is the primary function of the hypothalamus within the endocrine system?
What is the primary function of the hypothalamus within the endocrine system?
- To regulate thermoregulation exclusively
- To produce all hormones in the body
- To release hormones directly into the bloodstream
- To act as a coordinating center for endocrine activity (correct)
Which glands are primarily involved in the feedback control of hormone secretion?
Which glands are primarily involved in the feedback control of hormone secretion?
- Pituitary and thyroid glands
- Hypothalamus and target organ glands (correct)
- Thyroid and adrenal glands
- Adrenal and pancreas glands
What distinguishes exocrine glands from endocrine glands?
What distinguishes exocrine glands from endocrine glands?
- Exocrine glands release hormones directly into the bloodstream
- Exocrine glands are ductless structures
- Endocrine glands secrete hormones via ducts
- Endocrine glands release hormones directly into the bloodstream (correct)
What is a key role of the anterior pituitary hormones?
What is a key role of the anterior pituitary hormones?
How do the hypophysiotropic hormones affect the anterior pituitary?
How do the hypophysiotropic hormones affect the anterior pituitary?
Which of the following systems does the hypothalamus interface with?
Which of the following systems does the hypothalamus interface with?
What mainly regulates the plasma concentrations of nutrients and electrolytes?
What mainly regulates the plasma concentrations of nutrients and electrolytes?
What is the approximate size of the hypothalamus?
What is the approximate size of the hypothalamus?
What is the primary role of the hypothalamus in the endocrine system?
What is the primary role of the hypothalamus in the endocrine system?
How does the anterior pituitary connect to the hypothalamus?
How does the anterior pituitary connect to the hypothalamus?
What embryological origin is associated with the anterior pituitary?
What embryological origin is associated with the anterior pituitary?
What type of cells primarily compose the posterior pituitary?
What type of cells primarily compose the posterior pituitary?
Which behavioral responses are linked to internal stimuli from the body?
Which behavioral responses are linked to internal stimuli from the body?
What physiological structure lies in the sella turcica?
What physiological structure lies in the sella turcica?
How does the pituitary gland release hormones from the posterior side?
How does the pituitary gland release hormones from the posterior side?
Which system regulates internal homeostatic responses?
Which system regulates internal homeostatic responses?
What is the primary role of somatostatin in the endocrine system?
What is the primary role of somatostatin in the endocrine system?
Which releasing hormone is primarily responsible for stimulating the anterior pituitary to secrete ACTH?
Which releasing hormone is primarily responsible for stimulating the anterior pituitary to secrete ACTH?
What is the effect of prolactin-inhibiting hormone (PIH) on the mammary glands?
What is the effect of prolactin-inhibiting hormone (PIH) on the mammary glands?
Which hormone is primarily responsible for promoting water reabsorption in the kidneys?
Which hormone is primarily responsible for promoting water reabsorption in the kidneys?
Where is oxytocin produced in the endocrine system?
Where is oxytocin produced in the endocrine system?
What is an effect of oxytocin on the uterus?
What is an effect of oxytocin on the uterus?
In which nucleus is antidiuretic hormone (ADH) synthesized?
In which nucleus is antidiuretic hormone (ADH) synthesized?
What is a primary effect of growth hormone in the body?
What is a primary effect of growth hormone in the body?
What is the primary function of the hypothalamic hypophysiotropic hormones?
What is the primary function of the hypothalamic hypophysiotropic hormones?
What is the effect on prolactin when the hypothalamus-anterior pituitary link is damaged?
What is the effect on prolactin when the hypothalamus-anterior pituitary link is damaged?
Which of the following correctly pairs a hypothalamic hormone with its anterior pituitary target hormone?
Which of the following correctly pairs a hypothalamic hormone with its anterior pituitary target hormone?
What characterizes the secretion of hypothalamic hypophysiotropic hormones?
What characterizes the secretion of hypothalamic hypophysiotropic hormones?
Which statement is true regarding the regulation of growth hormone (GH) secretion?
Which statement is true regarding the regulation of growth hormone (GH) secretion?
Where is oxytocin primarily formed in the body?
Where is oxytocin primarily formed in the body?
What is the role of neurophysins in the secretion of oxytocin?
What is the role of neurophysins in the secretion of oxytocin?
How is oxytocin released from the nerve endings in the posterior pituitary gland?
How is oxytocin released from the nerve endings in the posterior pituitary gland?
Which hormones are secreted by the posterior pituitary gland?
Which hormones are secreted by the posterior pituitary gland?
What type of feedback mechanism does the hypothalamus utilize to maintain homeostasis?
What type of feedback mechanism does the hypothalamus utilize to maintain homeostasis?
Which hypothalamic hormone is synthesized in the pre-optic nucleus?
Which hypothalamic hormone is synthesized in the pre-optic nucleus?
What describes the ultrashort feedback loop in hormone secretion?
What describes the ultrashort feedback loop in hormone secretion?
What type of feedback loop involves hormones enhancing their own production?
What type of feedback loop involves hormones enhancing their own production?
Which hormones are primarily formed in the supraoptic nuclei?
Which hormones are primarily formed in the supraoptic nuclei?
The physiological response-driven feedback is primarily linked to which component?
The physiological response-driven feedback is primarily linked to which component?
Which of the following is NOT a type of feedback control mechanism for hormone secretion?
Which of the following is NOT a type of feedback control mechanism for hormone secretion?
Which two nuclei in the hypothalamus are known for housing neurosecretory neurons?
Which two nuclei in the hypothalamus are known for housing neurosecretory neurons?
What is the correct relationship between pituitary gland hormones and hypothalamic hormones in the short feedback loop?
What is the correct relationship between pituitary gland hormones and hypothalamic hormones in the short feedback loop?
What hormone stimulates the ovaries to induce ovulation and progesterone synthesis?
What hormone stimulates the ovaries to induce ovulation and progesterone synthesis?
Which nucleus is responsible for the secretion of Thyrotropin-Releasing Hormone (TRH)?
Which nucleus is responsible for the secretion of Thyrotropin-Releasing Hormone (TRH)?
What is the primary target organ for Adrenocorticotropic Hormone (ACTH)?
What is the primary target organ for Adrenocorticotropic Hormone (ACTH)?
Which physiological effect is directly associated with Thyroid-Stimulating Hormone (TSH)?
Which physiological effect is directly associated with Thyroid-Stimulating Hormone (TSH)?
Which of the following hormones is synthesized in response to Corticotropin-Releasing Hormone (CRH)?
Which of the following hormones is synthesized in response to Corticotropin-Releasing Hormone (CRH)?
What is the physiological role of ACTH in the body?
What is the physiological role of ACTH in the body?
Which hormone is produced by the pituitary gland to regulate the proliferation and survival of adrenal cortex cells?
Which hormone is produced by the pituitary gland to regulate the proliferation and survival of adrenal cortex cells?
Which hormone is primarily correlated with the physiological effect of inducing ovulation?
Which hormone is primarily correlated with the physiological effect of inducing ovulation?
What is the role of somatostatin (GHIH) in the endocrine system?
What is the role of somatostatin (GHIH) in the endocrine system?
Which hormone is primarily responsible for stimulating milk ejection during lactation?
Which hormone is primarily responsible for stimulating milk ejection during lactation?
What effect does the prolactin-inhibiting hormone (PIH) have on lactotropes in the anterior pituitary?
What effect does the prolactin-inhibiting hormone (PIH) have on lactotropes in the anterior pituitary?
Which hormone is secreted by the anterior pituitary to stimulate cortisol production in the adrenal glands?
Which hormone is secreted by the anterior pituitary to stimulate cortisol production in the adrenal glands?
Where is antidiuretic hormone (ADH) primarily synthesized?
Where is antidiuretic hormone (ADH) primarily synthesized?
During childbirth, which hormone facilitates uterine contractions?
During childbirth, which hormone facilitates uterine contractions?
What is the effect of antidiuretic hormone (ADH) on the kidneys?
What is the effect of antidiuretic hormone (ADH) on the kidneys?
Which nucleus in the hypothalamus is primarily associated with the production of oxytocin?
Which nucleus in the hypothalamus is primarily associated with the production of oxytocin?
What is the primary structural difference between the anterior and posterior pituitary glands?
What is the primary structural difference between the anterior and posterior pituitary glands?
Which of the following best describes the connection between the hypothalamus and the anterior pituitary?
Which of the following best describes the connection between the hypothalamus and the anterior pituitary?
What physiological role does the hypothalamus serve within the endocrine system?
What physiological role does the hypothalamus serve within the endocrine system?
Which pituitary structure primarily contains glial-type cells?
Which pituitary structure primarily contains glial-type cells?
What is the primary function of the anterior pituitary in the endocrine system?
What is the primary function of the anterior pituitary in the endocrine system?
How does the endocrine system maintain internal homeostasis?
How does the endocrine system maintain internal homeostasis?
What type of stimuli does the hypothalamus integrate to regulate hormone release?
What type of stimuli does the hypothalamus integrate to regulate hormone release?
Which of the following statements about the embryology of the pituitary gland is true?
Which of the following statements about the embryology of the pituitary gland is true?
What is the primary mechanism by which hypothalamic hormones reach the anterior pituitary?
What is the primary mechanism by which hypothalamic hormones reach the anterior pituitary?
Which of the following correctly explains the secretion pattern of hypothalamic hormones?
Which of the following correctly explains the secretion pattern of hypothalamic hormones?
Which hormone is known to have an inhibitory effect on prolactin secretion?
Which hormone is known to have an inhibitory effect on prolactin secretion?
What occurs to anterior pituitary hormone production when the link between the hypothalamus and the anterior pituitary is disrupted?
What occurs to anterior pituitary hormone production when the link between the hypothalamus and the anterior pituitary is disrupted?
How is the secretion of growth hormone regulated?
How is the secretion of growth hormone regulated?
Which feedback mechanism implies that a hormone can inhibit its own secretion?
Which feedback mechanism implies that a hormone can inhibit its own secretion?
Which hormone is primarily synthesized in the paraventricular nucleus of the hypothalamus?
Which hormone is primarily synthesized in the paraventricular nucleus of the hypothalamus?
What is the main characteristic of a long feedback loop in hormone secretion?
What is the main characteristic of a long feedback loop in hormone secretion?
Which hormone, when secreted during the female reproductive cycle, typically operates under a positive feedback mechanism?
Which hormone, when secreted during the female reproductive cycle, typically operates under a positive feedback mechanism?
Which cluster of neurons in the hypothalamus is primarily associated with the synthesis of oxytoxin?
Which cluster of neurons in the hypothalamus is primarily associated with the synthesis of oxytoxin?
What physiological response is primarily linked to negative feedback control mechanisms?
What physiological response is primarily linked to negative feedback control mechanisms?
What type of neurosecretory neurons predominately lie in the supraoptic nuclei?
What type of neurosecretory neurons predominately lie in the supraoptic nuclei?
Which physiological response is characterized by short feedback loops inhibiting hypothalamic hormone release?
Which physiological response is characterized by short feedback loops inhibiting hypothalamic hormone release?
Which hormone is solely responsible for stimulating milk production?
Which hormone is solely responsible for stimulating milk production?
Which anterior pituitary hormone does NOT stimulate the secretion of another hormone?
Which anterior pituitary hormone does NOT stimulate the secretion of another hormone?
What is the primary role of Thyrotropin (TSH) in the endocrine system?
What is the primary role of Thyrotropin (TSH) in the endocrine system?
What function do the gonadotropins, LH and FSH, serve in males?
What function do the gonadotropins, LH and FSH, serve in males?
Which cell type is responsible for synthesizing Adrenocorticotropin (ACTH)?
Which cell type is responsible for synthesizing Adrenocorticotropin (ACTH)?
Which hormone primarily regulates the metabolism of carbohydrates and lipids in the body?
Which hormone primarily regulates the metabolism of carbohydrates and lipids in the body?
What are the two main factors that regulate anterior pituitary hormone secretion?
What are the two main factors that regulate anterior pituitary hormone secretion?
Which hormone is responsible for regulating the proliferation and survival of thyroid cells?
Which hormone is responsible for regulating the proliferation and survival of thyroid cells?
Flashcards
Endocrine System
Endocrine System
A major regulatory system that coordinates life-sustaining responses. It is made up of several hormone-producing "endocrine glands" (e.g. pituitary and thyroid glands). These glands are ductless and release hormones directly into the bloodstream. They are found in various locations within the body.
Endocrine Glands
Endocrine Glands
Specialized cells that produce and secrete hormones directly into the bloodstream. Examples include the pituitary and thyroid glands.
Hormonal Action and Regulation
Hormonal Action and Regulation
Hormones act on target cells to regulate the concentration of substances in the blood, such as nutrients, water, salt, and electrolytes.
Diffuse Endocrine System
Diffuse Endocrine System
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Hypothalamus: Control Center of the Endocrine System
Hypothalamus: Control Center of the Endocrine System
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Connections of the Hypothalamus
Connections of the Hypothalamus
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Hypothalamus: Interface Between Internal and External Environments
Hypothalamus: Interface Between Internal and External Environments
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Hypothalamus: Functions and Regulation
Hypothalamus: Functions and Regulation
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Hypothalamic Hypophysiotropic Hormones
Hypothalamic Hypophysiotropic Hormones
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Hypothalamic-Hypophyseal Portal System
Hypothalamic-Hypophyseal Portal System
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Prolactin
Prolactin
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Hypothalamic Hormone Naming
Hypothalamic Hormone Naming
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Prolactin Inhibiting Hormone (PIH)
Prolactin Inhibiting Hormone (PIH)
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What is the pituitary gland?
What is the pituitary gland?
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What is the anterior pituitary?
What is the anterior pituitary?
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What is the posterior pituitary?
What is the posterior pituitary?
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What is the hypothalamus?
What is the hypothalamus?
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What is the hypothalamic-pituitary axis?
What is the hypothalamic-pituitary axis?
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How does the hypothalamus control the anterior pituitary?
How does the hypothalamus control the anterior pituitary?
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How does the hypothalamus control the posterior pituitary?
How does the hypothalamus control the posterior pituitary?
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How do the hypothalamus and pituitary gland work together?
How do the hypothalamus and pituitary gland work together?
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What is Oxytocin?
What is Oxytocin?
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What is the role of the hypothalamus in the endocrine system?
What is the role of the hypothalamus in the endocrine system?
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What is the main function of the anterior pituitary gland?
What is the main function of the anterior pituitary gland?
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What are the main hormones secreted by the posterior pituitary gland?
What are the main hormones secreted by the posterior pituitary gland?
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How does negative feedback work in the endocrine system?
How does negative feedback work in the endocrine system?
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Growth Hormone-Releasing Hormone (GHRH)
Growth Hormone-Releasing Hormone (GHRH)
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Somatostatin (GHIH)
Somatostatin (GHIH)
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Prolactin-Releasing Hormone (PRH)
Prolactin-Releasing Hormone (PRH)
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Prolactin-Inhibiting Hormone (PIH)/Dopamine
Prolactin-Inhibiting Hormone (PIH)/Dopamine
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Corticotropin-Releasing Hormone (CRH)
Corticotropin-Releasing Hormone (CRH)
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Gonadotropin Releasing Hormone (GnRH)
Gonadotropin Releasing Hormone (GnRH)
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Oxytocin
Oxytocin
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Antidiuretic Hormone (ADH) / Vasopressin
Antidiuretic Hormone (ADH) / Vasopressin
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Where are Hypothalamic Hypophysiotropic Hormones synthesized?
Where are Hypothalamic Hypophysiotropic Hormones synthesized?
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Negative Feedback in Hormone Secretion
Negative Feedback in Hormone Secretion
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Positive Feedback in Hormone Secretion
Positive Feedback in Hormone Secretion
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Hypothalamus & Posterior Pituitary
Hypothalamus & Posterior Pituitary
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Vasopressin (AVP) or Antidiuretic Hormone (ADH)
Vasopressin (AVP) or Antidiuretic Hormone (ADH)
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Releasing Hormones
Releasing Hormones
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Study Notes
Hypothalamus-Pituitary Target Organ Axes: Feedback Control 1
- The hypothalamus and pituitary gland are crucial parts of the endocrine system
- The hypothalamus is the central hub of the endocrine system
- It consolidates signals from various brain regions, autonomic functions, environmental cues, and other endocrine systems
- The hypothalamus sends precise signals to the pituitary gland.
- The pituitary gland then releases hormones that affect various endocrine systems.
- Hormones act on target cells to regulate nutrient levels, water, salts, and electrolytes.
- Hormones are crucial for metabolism, controlling growth and development, reproduction, and stress adaptation.
Learning Outcomes
- Outline the role of the hypothalamus and pituitary gland in the endocrine system
- Describe the functions of anterior pituitary hormones
- Describe the functions of posterior pituitary hormones
- Differentiate between the vascular and neural connections of the hypothalamus to the pituitary gland
- Understand how hypothalamic hypophysiotropic hormones regulate anterior pituitary hormone secretion
- Understand the role of feedback from target gland hormones in regulating anterior pituitary hormone secretion
Endocrine System and Hormones
- The endocrine system is a major regulatory system coordinating life-sustaining responses
- It consists of hormone-producing endocrine glands (e.g., pituitary, thyroid)
- Endocrine glands are ductless, releasing hormones directly into the bloodstream
- Endocrine cells are also found in other tissues, such as the stomach's G cells that secrete gastrin
- This is called the diffuse endocrine system.
Hypothalamus
- The hypothalamus is a coordinating center of the endocrine system
- Its size is less than 1% of the brain
- It is located below the thalamus and above the pituitary on either side of the third ventricle
- It's connected to numerous brain and spinal cord areas, particularly the limbic system and autonomic brainstem areas.
- It acts as an interface between the internal and external environments, receiving sensory information and responding internally
- It performs internal homeostatic responses using the autonomic nervous system and endocrine system
Pituitary Gland/Hypophysis
- The pituitary gland (hypophysis) is a small gland (1cm in diameter and weighing 0.5-1g)
- Located in the sella turcica (a bony cavity in the base of the brain)
- Physiologically divided into anterior pituitary (adenohypophysis) and posterior pituitary (neurohypophysis)
- Embryologically, these two portions originate from different sources
Pituitary Gland/Hypophysis-Embryology
- The anterior pituitary arises from an upward and outward pouching of the pharynx's epithelium (Rathke's pouch), explaining its epithelial nature
- The posterior pituitary originates from neural tissue outgrowth from the hypothalamus
- It contains a large number of glial-type cells
Hypothalamus & Pituitary Gland Relation
- The pituitary gland is connected to the hypothalamus via the pituitary stalk (connecting stalk)
- The hypothalamus communicates and regulates anterior pituitary function via the hypothalamic-hypophyseal portal system, a special vascular link
- The posterior pituitary is connected to the hypothalamus by a neural pathway
Hypothalamus & Pituitary Gland
- The hypothalamus is a central regulator.
- It releases releasing hormones
- Anterior pituitary releases tropic hormones (GH, TSH, ACTH).
- Posterior pituitary secretes ADH and oxytocin.
- Negative feedback maintains homeostasis by inhibiting upstream hormones and positive feedback increases secretion in specific cases (e.g., ovulation)
- These control growth, metabolism, stress responses, reproduction, and fluid balance
Hypothalamic Hypophysiotropic Hormones
- These are small peptide hormones, often named according to the target effect (e.g., TRH).
- Synthesized in the hypothalamus, packaged and transported down axons
- Sorted and released from terminals into the hypothalamic-hypophyseal portal system.
- Bind to receptors on cells in the anterior pituitary to modify hormone secretion.
Hypothalamic Hypophyseal Portal System
- A vascular link between the hypothalamus and anterior pituitary
- Hypophysiotropic hormones travel from hypothalamus to anterior pituitary via this system
- It controls anterior pituitary hormone release.
Anterior Pituitary Cell Types & Hormones
- The anterior pituitary consists of different cell types that synthesize and secrete hormones.
- Some examples of the different cell types include somatotropes, thyrotropes, lactotropes, gonadotropes, and corticotropes.
- Tropic hormones (or tropins) typically regulate the secretion and activity of other hormones within the endocrine system
- PRL is an exception, as it does not stimulate other hormones.
Functions of Anterior Pituitary Hormones
- GH: Stimulates secretion of IGF-1 from liver, impacting anabolic effects and metabolism.
- TSH: Regulates thyroid hormone synthesis and secretion, and impacts thyroid cell proliferation and survival
- ACTH: Stimulates adrenal cortex steroid and proliferation/survival of adrenal cells
- PRL: Stimulates milk production.
- LH and FSH: Affect reproductive function (ovulation and progesterone synthesis in females, testosterone production in males)
Feedback by Target Gland Hormones and Physiological Effects/Responses
- Hormones from peripheral endocrine glands play a crucial role influencing hypothalamic and pituitary hormone release. This is called feedback.
- The response to a hormone and negative feedback mechanisms help maintain homeostasis.
Hypothalamic-Posterior Pituitary
- A neuroendocrine system consisting of neurosecretory neurons with cell bodies in the hypothalamus (supraoptic and paraventricular nuclei)
- Hormones (vasopressin and oxytocin) are synthesized and transported to the posterior pituitary, stored in secretory vesicles, and released into systemic blood upon stimulation
- Vasopressin (ADH) and oxytocin are released from these neurons to control bodily functions.
Vasopressin & Oxytocin
- Vasopressin is synthesized in the supraoptic nuclei
- Oxytocin is synthesized in the paraventricular nuclei
- They are transported along axons to nerve endings in the posterior pituitary (as prohormones)
- Hormone release is triggered by nerve impulses and involves exocytosis, with neurophysins acting as carriers.
Multiple Choice Questions
- Questions related to the function of the hypothalamus, types of pituitary hormones and their secretion processes are provided.
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