Chapter 17 | Hypothalamic Regulation of Hormonal
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Questions and Answers

How is thirst affected by decreases in extracellular fluid (ECF) volume?

  • Increases thirst by decreasing renin secretion
  • Stimulates thirst through a pathway independent of increased plasma osmolality (correct)
  • Inhibits thirst by decreasing renin secretion
  • Has no effect on thirst
  • What is the role of angiotensin II in the hypothalamic regulation of thirst?

  • Stimulates the release of anti-thirst hormones
  • Has no impact on the thirst regulation process
  • Inhibits neural areas concerned with thirst
  • Acts on the subfornical organ to stimulate thirst-related neural areas (correct)
  • What stimulates renin secretion and leads to an increase in angiotensin II levels?

  • Increased blood pressure
  • Hypoventilation
  • Increased plasma osmolality
  • Hypovolemia (correct)
  • Which specialized receptor area in the diencephalon is stimulated by angiotensin II to affect thirst?

    <p>Subfornical organ</p> Signup and view all the answers

    What is one factor that contributes to an increase in liquid intake during eating?

    <p>Gastrointestinal hormone action on the hypothalamus</p> Signup and view all the answers

    What happens when the sensation of thirst is obtunded?

    <p>Patients stop drinking adequate amounts of fluid</p> Signup and view all the answers

    What contributes to most cases of hypernatremia?

    <p>Simple dehydration in patients with psychoses or hypothalamic disease</p> Signup and view all the answers

    Why does high protein intake lead to large amounts of water required to maintain hydration?

    <p>Products of protein metabolism cause an osmotic diuresis</p> Signup and view all the answers

    What is the main function of vasopressin mentioned in the text?

    <p>Promoting water retention by the kidney</p> Signup and view all the answers

    Where are vasopressin-secreting neurons found, according to the text?

    <p>Hypothalamus</p> Signup and view all the answers

    What are the types of vasopressin receptors mentioned in the text?

    <p>V1A, V1B, V2</p> Signup and view all the answers

    What is the physiological consequence of vasopressin's action on the kidney according to the text?

    <p>Decreased urine volume and concentration</p> Signup and view all the answers

    Which term is commonly used to refer to the chemical agents secreted by the hypothalamus into the portal hypophysial vessels?

    <p>Hypophysiotropic hormones</p> Signup and view all the answers

    Which hormone is now generally known as gonadotropin-releasing hormone (GnRH)?

    <p>Luteinizing hormone–releasing hormone (LHRH)</p> Signup and view all the answers

    What is the modern term used for Growth hormone–inhibiting hormone (GIH)?

    <p>Somatostatin</p> Signup and view all the answers

    Which of the following polypeptides found in the hypothalamus stimulates prolactin secretion?

    <p>VIP</p> Signup and view all the answers

    Where do most of the supraoptic fibers end in the hypothalamus?

    <p>Posterior lobe</p> Signup and view all the answers

    From where do sympathetic nerve fibers reach the anterior lobe of the pituitary gland?

    <p>Capsule</p> Signup and view all the answers

    What forms a direct vascular link between the hypothalamus and the anterior pituitary?

    <p>Portal hypophysial vessels</p> Signup and view all the answers

    What is a characteristic of the circulatory system connecting the hypothalamus and anterior pituitary, as described in the text?

    <p>Bypasses the heart</p> Signup and view all the answers

    What is the primary role of the hypothalamus in regulating the endocrine system?

    <p>Regulating emotional behavior</p> Signup and view all the answers

    How does the posterior pituitary gland connect to the hypothalamus?

    <p>Through neural connections</p> Signup and view all the answers

    In embryological terms, from where does the posterior pituitary gland originate?

    <p>Wall of the third ventricle</p> Signup and view all the answers

    What is the composition of the posterior pituitary?

    <p>Mainly consists of axon endings from specific nuclei</p> Signup and view all the answers

    What is the main effect of vasopressin on the kidney, as described in the text?

    <p>Increasing the permeability of the collecting ducts</p> Signup and view all the answers

    Where else in the body, besides the hypothalamus, are vasopressin and oxytocin found according to the text?

    <p>Adrenal cortex</p> Signup and view all the answers

    Which receptors are involved in the actions of vasopressin, as mentioned in the text?

    <p>V1A, V1B, V2</p> Signup and view all the answers

    What is one of the roles of vasopressin-secreting neurons found in the suprachiasmatic nuclei?

    <p>Controlling cardiovascular functions</p> Signup and view all the answers

    What is the physiologic role of hCRH-RII according to the text?

    <p>It is involved in receptor internalization in corticotropes</p> Signup and view all the answers

    Which type of hormones do NOT have known binding proteins according to the text?

    <p>Vasopressin</p> Signup and view all the answers

    In most mammals, which hormones are secreted by the posterior pituitary gland?

    <p>Vasopressin and oxytocin</p> Signup and view all the answers

    What is the main physiological consequence of oxytocin's action according to the text?

    <p>Promoting lactation and uterine contractions</p> Signup and view all the answers

    What is the physiologic role of CRH-binding protein in the peripheral circulation?

    <p>Inactivating CRH</p> Signup and view all the answers

    In most mammals, what are the hormones secreted by the posterior pituitary gland?

    <p>Vasopressin and oxytocin</p> Signup and view all the answers

    Where is hCRH-RII primarily found?

    <p>Many parts of the brain</p> Signup and view all the answers

    What is the main physiological action of vasopressin?

    <p>Increasing urine concentration</p> Signup and view all the answers

    Which part of the body does oxytocin primarily act on?

    <p>Breasts and uterus</p> Signup and view all the answers

    The hypothalamus regulates emotional and instinctual behavior independently of the limbic system.

    <p>False</p> Signup and view all the answers

    The posterior pituitary arises from the floor of the fourth ventricle.

    <p>False</p> Signup and view all the answers

    Vasopressin and oxytocin primarily act on the adrenal glands.

    <p>False</p> Signup and view all the answers

    The anterior pituitary is directly connected to the hypothalamus via neural connections.

    <p>False</p> Signup and view all the answers

    Hemorrhage can lead to decreased drinking even if plasma osmolality remains unchanged.

    <p>False</p> Signup and view all the answers

    Renin secretion is decreased by hypovolemia, resulting in a decrease in circulating angiotensin II.

    <p>False</p> Signup and view all the answers

    The subfornical organ is not involved in the stimulation of neural areas related to thirst.

    <p>False</p> Signup and view all the answers

    The organum vasculosum of the lamina terminalis (OVLT) is not affected by angiotensin II according to some evidences.

    <p>False</p> Signup and view all the answers

    Thirst response to hypovolemia is completely blocked by drugs that block the action of angiotensin II.

    <p>False</p> Signup and view all the answers

    High protein intake causes a decrease in the amounts of water required to maintain hydration.

    <p>False</p> Signup and view all the answers

    Patients with psychoses or hypothalamic disease always increase their water intake when their thirst mechanism is stimulated.

    <p>False</p> Signup and view all the answers

    An increase in plasma osmolality occurs as food is absorbed, contributing to a learned response of increased liquid intake during eating.

    <p>True</p> Signup and view all the answers

    Hypophysiotropic hormones are commonly known as releasing and inhibiting factors.

    <p>False</p> Signup and view all the answers

    Prolactin-releasing hormone (PRH) has been confirmed to exist according to the text.

    <p>False</p> Signup and view all the answers

    VIP is one of the hypothalamic polypeptides that stimulate prolactin secretion.

    <p>True</p> Signup and view all the answers

    Luteinizing hormone–releasing hormone (LHRH) is generally known as corticotropin-releasing hormone (CRH).

    <p>False</p> Signup and view all the answers

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