endocrine phy
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Questions and Answers

Which of the following hormones is NOT primarily associated with the digestive system?

  • Secretin
  • Adrenocorticotropic hormone (ACTH) (correct)
  • Gastric Inhibitory Peptide (GIP)
  • Cholecystokinin (CCK)

Anterior pituitary is an example of which complexity of the endocrine system?

  • One hormone may be secreted by >1 endocrine gland
  • Some may be hormones and neurotransmitters
  • One endocrine gland may secrete >1 hormone (correct)
  • One target cell may be influenced by >1 hormone

What is the primary mechanism by which negative feedback control regulates hormone secretion?

  • Promoting the accumulation of hormone receptors on endocrine cells.
  • Stimulating the release of tropic hormones from the hypothalamus.
  • Counteracting changes in inputs to turn off the output of a system. (correct)
  • Enhancing the sensitivity of target cells to the hormone.

Which factor does NOT directly influence the effective plasma concentration of a hormone?

<p>The size of the target organ (A)</p> Signup and view all the answers

Which hormone is known to be secreted by more than one endocrine gland?

<p>Somatostatin (A)</p> Signup and view all the answers

Which of the following hormones is associated with the cardiovascular system, according to the content?

<p>Adrenaline (C)</p> Signup and view all the answers

If a drug inhibits the binding of a hormone to its plasma protein, what is the most likely immediate effect on the hormone's activity?

<p>Increased availability of free hormone to target tissues (A)</p> Signup and view all the answers

If a researcher discovers a new hormone that affects multiple target cells and elicits different responses in each, which endocrine system complexity is best exemplified?

<p>One hormone may have &gt;1 target cell, thus &gt;1 type of action (A)</p> Signup and view all the answers

Which characteristic distinguishes the endocrine system from the nervous system?

<p>The endocrine system relies on ductless glands to secrete hormones into the bloodstream. (A)</p> Signup and view all the answers

What is the primary role of hormones within the endocrine system?

<p>To relay information and instructions to cells, initiating a signaling cascade. (A)</p> Signup and view all the answers

Which of the following is an example of a central endocrine gland?

<p>Pineal gland (A)</p> Signup and view all the answers

How do tropic hormones exert their effect within the endocrine system?

<p>By stimulating other endocrine glands to release hormones. (D)</p> Signup and view all the answers

A scientist is studying a newly discovered hormone. Initial analysis reveals it is derived from amino acids and is water-soluble. Which class of hormones does it most likely belong to?

<p>Peptide hormones (A)</p> Signup and view all the answers

A patient has a tumor that causes excessive secretion of a hormone from the anterior pituitary. Which of the following could be a consequence of this condition?

<p>Disruption of homeostasis due to hormonal imbalance (B)</p> Signup and view all the answers

Which of the following best explains why lipophilic hormones, such as steroid hormones, typically have a longer half-life compared to hydrophilic hormones?

<p>Lipophilic hormones bind to carrier proteins in the blood, protecting them from degradation and extending their duration of action. (D)</p> Signup and view all the answers

If the hypothalamus is damaged, which of the following is the most likely direct consequence on endocrine function?

<p>Disruption of the communication between the nervous and endocrine systems (B)</p> Signup and view all the answers

A patient exhibits reduced sensitivity to insulin after prolonged hypersecretion. Which mechanism most likely explains this phenomenon?

<p>Desensitization due to a local negative feedback loop. (D)</p> Signup and view all the answers

Which of the following best describes a permissive hormonal interaction?

<p>One hormone is required for another hormone to exert its effects. (A)</p> Signup and view all the answers

A patient's blood test reveals abnormally low levels of a particular hormone. If the problem originates in the endocrine gland that directly produces the hormone, this is an example of what?

<p>Primary hyposecretion. (A)</p> Signup and view all the answers

Thyroid hormones circulate in the bloodstream for a longer duration compared to free hormones because they are:

<p>Bound to carrier proteins in the plasma. (D)</p> Signup and view all the answers

How does the presence or absence of hormone receptors affect a target cell's response?

<p>It dictates the cell's sensitivity to the hormone. (D)</p> Signup and view all the answers

What is the expected result of a hormone's binding to its receptor on a target cell?

<p>Initiation of downstream signaling events. (D)</p> Signup and view all the answers

Which of the following is an example of a stimulus that could trigger hormone release?

<p>The arrival of neurotransmitters at a cell. (C)</p> Signup and view all the answers

Compared to hormones that circulate freely, steroid hormones generally:

<p>Are involved in long-term developmental changes. (A)</p> Signup and view all the answers

Which of the following is NOT a function of the hypothalamus?

<p>Directly secreting hormones into the general circulation to affect distant target cells. (A)</p> Signup and view all the answers

Vasopressin and oxytocin are synthesized in the hypothalamus and released from the posterior pituitary. What cellular structure facilitates the transport of these hormones from the site of synthesis to the site of release?

<p>Axons (D)</p> Signup and view all the answers

Which anterior pituitary hormone does NOT have a tropic function?

<p>Prolactin (PRL) (A)</p> Signup and view all the answers

A patient is experiencing difficulty with milk production after childbirth. Which of the following hormones is MOST likely deficient?

<p>Prolactin (PRL) (A)</p> Signup and view all the answers

If the hypophyseal portal system is damaged, which of the following would be the MOST immediate and direct consequence?

<p>Disrupted communication between the hypothalamus and anterior pituitary. (C)</p> Signup and view all the answers

In a negative feedback loop involving cortisol, which hormone(s) would be expected to decrease when cortisol levels are high?

<p>Both ACTH and CRH (B)</p> Signup and view all the answers

Which of the following is a direct effect of growth hormone (GH)?

<p>Mobilization of fats from adipose tissue (A)</p> Signup and view all the answers

Dwarfism can result from hyposecretion of Growth Hormone. Which of the following could be a cause of hypersecretion of Growth Hormone?

<p>Tumors (A)</p> Signup and view all the answers

Besides growth hormone, which of the following hormones is MOST crucial for normal skeletal growth in children?

<p>Thyroid Hormone (D)</p> Signup and view all the answers

What is the primary function of the pineal gland?

<p>Secreting melatonin to regulate circadian rhythms (C)</p> Signup and view all the answers

A researcher is investigating the effects of a new drug on the endocrine system. They observe that the drug significantly reduces the secretion of FSH and LH. Which hypothalamic hormone is MOST likely being targeted by this drug?

<p>Gonadotropin-Releasing Hormone (GnRH) (C)</p> Signup and view all the answers

How do the roles of Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) differ in females?

<p>FSH stimulates gamete (ova) production; LH regulates sex hormone secretion, ovulation, and luteinization. (B)</p> Signup and view all the answers

Which of the following describes the mechanism of action of hypothalamic hormones on the anterior pituitary gland?

<p>Secretion into the hypophyseal portal system for targeted delivery to anterior pituitary cells. (B)</p> Signup and view all the answers

Given the functions of ADH (vasopressin) and oxytocin, predict the physiological response to dehydration and social interaction, respectively.

<p>Increased water reabsorption in the kidneys; enhancement of social bonding. (D)</p> Signup and view all the answers

How does somatostatin, released by the hypothalamus, affect the anterior pituitary gland?

<p>Inhibits the release of growth hormone (GH) and thyroid-stimulating hormone (TSH). (D)</p> Signup and view all the answers

A patient presents with symptoms of increased metabolic rate, weight loss despite increased appetite, and a rapid heartbeat. If these symptoms are caused by a hormonal imbalance, which peripheral endocrine gland is MOST likely involved?

<p>Thyroid gland (D)</p> Signup and view all the answers

A person experiencing chronic stress exhibits elevated levels of cortisol. Which of the following is a likely long-term effect of this hormonal imbalance on a peripheral endocrine gland?

<p>Decreased bone density due to altered calcium metabolism. (D)</p> Signup and view all the answers

Which of the following scenarios BEST illustrates the interplay between a central endocrine gland and a peripheral endocrine gland?

<p>The adrenal gland releasing cortisol in response to ACTH from the anterior pituitary. (A)</p> Signup and view all the answers

A researcher is studying the effect of a new drug on glucose metabolism. The drug increases insulin secretion but simultaneously reduces the sensitivity of target cells to insulin. Which peripheral endocrine gland is the primary target of this drug's action?

<p>Pancreas (C)</p> Signup and view all the answers

A woman is experiencing irregular menstrual cycles and difficulty conceiving. Blood tests reveal an imbalance in estrogen and progesterone levels. Which peripheral endocrine glands are MOST likely involved in these hormone imbalances?

<p>Ovaries (C)</p> Signup and view all the answers

Which condition is characterized by excessive cortisol secretion from the adrenal cortex?

<p>Cushing's syndrome (D)</p> Signup and view all the answers

What is the expected outcome when the two amino acid chains that compose insulin are separated?

<p>Insulin's functional activity is lost. (A)</p> Signup and view all the answers

Which of the following is a hormone secreted by the endocrine pancreas that inhibits growth hormone secretion?

<p>Somatostatin (D)</p> Signup and view all the answers

If a patient is diagnosed with Conn's syndrome, which hormone is most likely being hypersecreted?

<p>Aldosterone (B)</p> Signup and view all the answers

What structural feature is essential for the functional activity of normal human insulin?

<p>Two amino acid chains connected by disulfide linkages (C)</p> Signup and view all the answers

Which pancreatic hormone is primarily responsible for increasing blood glucose levels during periods of fasting or exercise?

<p>Glucagon (B)</p> Signup and view all the answers

A patient presents with symptoms suggestive of adrenocortical insufficiency. Which of the following conditions is most likely responsible for these symptoms?

<p>Addison's disease (C)</p> Signup and view all the answers

In the context of fuel metabolism, how do insulin and glucagon interact to maintain glucose homeostasis?

<p>They are secreted by the pancreas and have opposing effects on blood glucose levels. (B)</p> Signup and view all the answers

A patient is experiencing prolonged stress. Which hormonal change would MOST likely be observed?

<p>Increased cortisol secretion resulting in elevated blood glucose levels (B)</p> Signup and view all the answers

A researcher is studying the impact of hormone imbalances on blood pressure regulation. Which scenario would MOST directly involve the adrenal cortex?

<p>Sodium retention leading to increased blood volume due to increased aldosterone secretion from the adrenal cortex (C)</p> Signup and view all the answers

A patient presents with symptoms suggesting an adrenal gland disorder. If tests reveal that the zona reticularis is primarily affected, which hormonal imbalance is MOST likely contributing to these symptoms?

<p>Disrupted early development of sex organs due to abnormal DHEA production (D)</p> Signup and view all the answers

A patient's blood work indicates elevated levels of adrenaline and noradrenaline. Considering the source of these hormones, which physiological response would be the MOST expected?

<p>Increased heart rate and reinforcement of the sympathetic nervous system (D)</p> Signup and view all the answers

If a drug selectively inhibits the enzyme responsible for the synthesis of cortisol in the adrenal cortex, but does not affect the other zones, what is the MOST likely outcome?

<p>Reduced capacity to adapt to stress due to decreased cortisol levels (D)</p> Signup and view all the answers

Which of the following scenarios would MOST likely result in the formation of a goiter?

<p>Autoimmune disease where thyroid-stimulating immunoglobulin (TSI) is produced. (D)</p> Signup and view all the answers

How does increased thyroid hormone in the body affect the secretion of TSH (thyroid-stimulating hormone) by the anterior pituitary?

<p>It decreases TSH secretion through negative feedback, reducing further thyroid stimulation. (A)</p> Signup and view all the answers

The sympathomimetic effect of thyroid hormones primarily results in which of the following physiological changes?

<p>Increased heart rate, force of contraction, and cardiac output. (B)</p> Signup and view all the answers

If a patient presents with an abnormally high metabolic rate, increased body temperature, and elevated heart rate, which hormonal imbalance is the MOST likely cause?

<p>Hypersecretion of thyroid hormones. (C)</p> Signup and view all the answers

If a researcher is studying the mechanism by which thyroid hormones affect growth, which other hormone's secretion would be MOST relevant to monitor?

<p>Growth Hormone (GH). (B)</p> Signup and view all the answers

Considering TSH's regulatory mechanism, what immediate effect would separation of the anterior pituitary from the hypothalamus have on the feedback control of thyroid hormone secretion?

<p>The feedback depressant effect on TSH would still occur. (B)</p> Signup and view all the answers

In a patient experiencing chronic stress, which hormone(s) released from the adrenal glands would be MOST directly involved in helping the body adapt to the stress?

<p>Cortisol, primarily, by modulating glucose metabolism and immune response. (D)</p> Signup and view all the answers

Which adrenal hormone directly influences blood pressure by increasing sodium reabsorption in the kidneys?

<p>Aldosterone. (D)</p> Signup and view all the answers

How does insulin facilitate glucose uptake in muscle cells?

<p>By binding with and activating the insulin receptor protein. (C)</p> Signup and view all the answers

What physiological effect does glucagon have on blood glucose levels?

<p>Opposes the actions of insulin, generally increasing blood glucose. (C)</p> Signup and view all the answers

During the postabsorptive state (fasting), what hormonal change would you expect to observe?

<p>Decreased insulin and increased glucagon secretion. (C)</p> Signup and view all the answers

What is the expected hormonal response to elevated blood glucose levels?

<p>Inhibited glucagon secretion and stimulated insulin secretion. (A)</p> Signup and view all the answers

Which of the following best describes the interplay between insulin and glucagon in maintaining blood glucose levels?

<p>They work as a team; insulin lowers blood glucose, while glucagon raises it. (B)</p> Signup and view all the answers

In addition to its role in the hypothalamus, where else is somatostatin produced, and what function does it serve in that location?

<p>Pancreas, inhibiting the secretion of insulin and glucagon. (A)</p> Signup and view all the answers

How does the absence of insulin affect glucose concentration inside muscle cells?

<p>It decreases glucose concentration because glucose entry into the cells is reduced. (D)</p> Signup and view all the answers

What is the primary reason for glucose appearing in the urine of individuals with untreated diabetes mellitus?

<p>High glucose levels in the blood overwhelm reabsorption capabilities of the kidneys. (A)</p> Signup and view all the answers

If a patient has a condition that impairs the function of osteoblasts, which of the following is the most likely direct consequence?

<p>Decreased bone deposition (B)</p> Signup and view all the answers

Which statement best describes how calcium and phosphate are distributed within the body?

<p>Both calcium and phosphate are predominantly stored in bones. (B)</p> Signup and view all the answers

What is the role of osteoclasts in bone remodeling?

<p>Resorbing bone where they are active (C)</p> Signup and view all the answers

How do osteoblasts influence osteoclast development?

<p>They produce chemicals that govern osteoclast development. (D)</p> Signup and view all the answers

Considering the distribution of calcium in the body, a sudden drop in extracellular calcium levels would likely be compensated by which mechanism?

<p>Release of calcium from bone stores (B)</p> Signup and view all the answers

If a researcher aims to study the immediate effects of a drug on bone resorption, which cell type should be the primary focus of their investigation?

<p>Osteoclasts (C)</p> Signup and view all the answers

If a patient is diagnosed with hyperparathyroidism (overactive parathyroid glands), which of the following scenarios is most likely to occur, considering the interrelation between calcium and phosphate homeostasis?

<p>Increased blood calcium and decreased blood phosphate levels (B)</p> Signup and view all the answers

What is the most likely origin of osteoclasts?

<p>Macrophages (A)</p> Signup and view all the answers

Flashcards

Endocrine Glands

Ductless glands secreting messengers into the bloodstream to act on distant target cells.

Hormones

Chemical messengers relaying information and instructions to cells.

Endocrine System Function

Maintaining stable internal conditions and regulating long-term processes.

Central Endocrine Glands

The hypothalamus, anterior pituitary, posterior pituitary, and pineal gland.

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Hydrophilic Hormones

Hormones that are attracted to water.

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Lipophilic Hormones

Hormones that are attracted to lipids (fats).

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Examples of Hydrophilic Hormones

Peptide hormones, catecholamines.

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Examples of Lipophilic Hormones

Steroid hormones, thyroid hormones.

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Indoleamines

A class of neurotransmitters and hormones derived from tryptophan, including serotonin and melatonin. Serotonin is the most abundant.

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Multiple Secretion

A hormone can be secreted from more than one endocrine gland.

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Multiple Target Actions

A hormone can influence multiple types of target cells and therefore have multiple types of actions.

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Hormonal Influence

A target cell can be influenced by more than one hormone at a time.

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Endocrine vs. Multi-Functional Glands

Some glands solely produce hormones; others perform additional non-endocrine functions.

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Cyclic Hormone Secretion

Hormone secretion rates can fluctuate predictably over time.

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Hormones & Neurotransmitters

Some substances act as both hormones (in the bloodstream) and neurotransmitters (in the nervous system).

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Effective Plasma Concentration

The concentration of a hormone is affected by its secretion rate, activation, transport and removal.

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"Fight or Flight" Response

Rapid physiological response to perceived danger or stress.

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Circadian/Diurnal Rhythm

Cycles that repeat approximately every 24 hours.

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Hormone Distribution

Hormones circulate freely or bind to carrier proteins in plasma.

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Hormone Receptors

Protein molecules on target cells that bind to a specific hormone.

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Upregulation

Increasing the number of receptors on a target cell.

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Downregulation

Decreasing the number of receptors on a target cell.

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Permissive Hormone Interaction

One hormone is needed for another to produce an effect.

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Antagonistic Hormone Interaction

Opposite hormonal effects when two hormone act on a target cell at the same time.

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Pituitary Gland

Often called the "master gland," it controls other endocrine glands.

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Hypothalamus Role

These work together to secrete vasopressin and oxytocin and to secrete hypothalamic releasing or inhibiting hormones.

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ADH & Oxytocin Functions

Vasopressin (ADH) regulates water conservation, while oxytocin regulates love and bonding.

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Anterior Pituitary Hormones

Growth Hormone (GH) affects body growth, Thyroid Stimulating Hormone (TSH) affects thyroid function, and Adrenocorticotropic Hormone (ACTH) affects adrenal cortex function.

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GH Function

Growth hormone promotes overall body growth by binding to adipose tissue, skeletal muscles & liver.

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TSH Function

Stimulates secretion of thyroid hormone & growth of thyroid gland.

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FSH, LH

Follicle-stimulating hormone (FSH) and Luteinizing hormone (LH) work together to regulate gonads function.

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FSH Function

Gametes production (ova, sperm).

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LH Function

Regulate secretion of sex hormones, ovulation, luteinization.

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PRL

Prolactin (PRL) promotes lactation.

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Hypothalamic Hormones

Growth Hormone-Releasing Hormone (GHRH), Thyrotropin-Releasing Hormone (TRH), Corticotropin-Releasing Hormone (CRH), Gonadotropin-Releasing Hormone (GnRH).

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Hypothalamic-Hypophyseal Portal System

It connects the hypothalamus to the anterior pituitary via a unique vascular link.

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Cortisol Secretion Example

Cortisol secretion, begins with CRH from the hypothalamus, then ACTH from the anterior pituitary, and cortisol from the adrenal cortex.

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Abnormal GH Secretion

GH deficiency leads to dwarfism, while GH excess results in gigantism or acromegaly.

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Pineal Gland

Secretes melatonin.

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Peripheral Endocrine Glands

Glands located outside the brain, including the thyroid, adrenal glands, pancreas, and gonads.

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Endocrine System

The body system using hormones to regulate various bodily functions.

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Intracellular Communication (Endocrine)

Chemical signaling where cells communicate through the bloodstream.

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Hormone Functions

Chemicals produced by endocrine glands that travel through the bloodstream to target cells.

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Hormone-Producing Organ Systems

Organ systems involved in hormone production, such as the reproductive system, adrenal glands, and pancreas.

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Thyroid Hormone's Effect on GH

Stimulates GH secretion and increases IGF-I production by the liver.

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Sympathomimetic Effect

Mimics the effects of the sympathetic nervous system.

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Thyroid Hormone's Effect on Heart

Increases heart rate, force of contraction, and cardiac output.

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Calorigenic Effect

Increases metabolic rate and heat production.

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Goiter Development

Enlargement of the thyroid gland due to overstimulation or lack of stimulation.

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Adrenal Cortex Hormones

Secretes aldosterone, cortisol and adrenal androgens (DHEA).

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Adrenal medulla

Secretes adrenaline/noradrenaline for fight or flight.

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Aldosterone Action

Regulates sodium and potassium balance.

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Adrenal Glands

Gland located on top of the kidneys, consisting of the cortex and medulla.

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Adrenal Cortex

The outer layer of the adrenal gland, has three distinct layers.

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Aldosterone

A hormone secreted by the adrenal cortex (zona glomerulosa) that regulates sodium, potassium balance, and blood pressure.

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Cortisol

A hormone secreted by the adrenal cortex (zona fasciculata) that aids in adaptation to stress, metabolic regulation and anti-inflammatory effects.

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Adrenal Androgens (DHEA)

Hormones secreted by the adrenal cortex (zona reticularis) that contribute to early development of sex organs.

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Hyperglycemia

Abnormally high glucose levels in the blood.

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Diabetes Mellitus

A disease characterized by high glucose concentrations that overwhelm kidney reabsorption, leading to glucose in urine and excessive urine volume.

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Polyuria

The condition where urine volume becomes excessive.

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Glucagon

A hormone that generally opposes the actions of insulin.

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Hypoglycemia

Low blood glucose levels, often caused by excess insulin, starving the brain of energy.

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Glycogenolysis

The process of breaking down glycogen into glucose.

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Somatostatin

A hormone that inhibits the secretion of growth hormone (GH) and thyroid stimulating hormone (TSH) from the pituitary gland.

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Somatostatin

A hormone that inhibits the secretion of insulin and glucagon from the pancreas.

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Cortisol Hypersecretion

Excessive secretion of cortisol by the adrenal cortex.

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Aldosterone Hypersecretion

Excessive secretion of aldosterone.

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Adrenocortical Insufficiency

Insufficient secretion of hormones from the adrenal cortex.

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Vasopressin

Also known as antidiuretic hormone (ADH), regulates water reabsorption in the kidneys.

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Insulin

Hormone secreted by the pancreas that lowers blood glucose levels.

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Nutrient Utilization Decrease

Decreases how well tissues use absorbed nutrients.

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Calcium & Phosphate Homeostasis

Close relationship between maintaining proper phosphate and calcium levels.

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Parathyroid Glands

Regulates calcium levels through hormone secretion.

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Bone Remodeling

The continuous process of bone breakdown and rebuilding.

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Osteoblasts

Cells that build new bone.

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Osteoclasts

Cells that break down bone.

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Osteoblast Origin

Derived from bone marrow precursor cells.

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Osteoclast Origin

Differentiate from macrophages.

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Study Notes

Endocrine System

  • Examples of intercellular communication: ions, small solutes, lipid-soluble materials via gap junctions, and neurotransmitters across synapses.

Hormone Action and Control

  • Effective hormone plasma concentration is expressed through hormone availability and magnitude.

Central Endocrine Glands Detailed

  • Hypothalamic hormones secreted to control anterior pituitary stimulation ACTH, TSH, PRL FSH, LH and GH secretion, or inhibit GH and PRL.

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Description

Test your knowledge of endocrine system hormones. This quiz covers hormone production, secretion, and their diverse effects on the body. Learn about feedback mechanisms and hormone interactions.

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