Endocrine System Disorders

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Questions and Answers

Which diagnostic test is most effective in distinguishing between the various underlying causes of hyperthyroidism?

  • Fasting blood glucose test
  • Electrocardiogram (ECG)
  • Radioactive iodine uptake (RAIU) test (correct)
  • 24-hour urine cortisol test

In industrialized nations, what is the predominant cause of primary adrenocortical insufficiency (Addison’s disease)?

  • Autoimmune destruction of the adrenal cortex (correct)
  • Pituitary adenoma
  • Fungal infections
  • Tuberculosis

Which electrolyte imbalance is most likely to be observed in a patient diagnosed with Cushing’s syndrome?

  • Hyperkalemia and hyponatremia
  • Hypoglycemia and hyperkalemia
  • Hypokalemia and hypernatremia (correct)
  • Hypercalcemia and hyperglycemia

Why do patients with Cushing’s syndrome typically exhibit truncal obesity alongside thin extremities?

<p>Protein catabolism leading to muscle wasting in the extremities while fat accumulates centrally (D)</p> Signup and view all the answers

Which hormone is primarily responsible for the body's regulation of sodium and water retention?

<p>Aldosterone (A)</p> Signup and view all the answers

What is a key clinical characteristic frequently observed in patients with hyperthyroidism?

<p>Exophthalmos and tachycardia (A)</p> Signup and view all the answers

Which electrolyte imbalance is typically associated with Addison’s disease?

<p>Hyponatremia and hyperkalemia (B)</p> Signup and view all the answers

Which of the following factors poses a significant risk for the development of Cushing’s syndrome?

<p>Long-term corticosteroid therapy (A)</p> Signup and view all the answers

What is the primary therapeutic objective when managing Cushing’s syndrome?

<p>Normalizing hormone secretion by addressing the underlying cause (B)</p> Signup and view all the answers

If left unmanaged, which of the following represents a potential complication of hypothyroidism?

<p>Myxedema coma (C)</p> Signup and view all the answers

Which diagnostic test is utilized to confirm a diagnosis of Addison’s disease?

<p>ACTH stimulation test (B)</p> Signup and view all the answers

What immediate intervention is most critical for a patient undergoing an Addisonian crisis?

<p>Providing corticosteroid replacement therapy (D)</p> Signup and view all the answers

Which clinical manifestation is commonly observed in patients with Cushing’s syndrome?

<p>Moon face and truncal obesity (D)</p> Signup and view all the answers

What dietary recommendation is most suitable for a patient diagnosed with hyperthyroidism?

<p>High-calorie, high-protein diet (B)</p> Signup and view all the answers

Which statement accurately describes radioactive iodine therapy as a treatment for hyperthyroidism?

<p>It destroys thyroid tissue to reduce hormone secretion (C)</p> Signup and view all the answers

Flashcards

RAIU Test

Differentiates causes of hyperthyroidism by measuring how much iodine the thyroid absorbs.

Addison's Disease Cause

Autoimmune destruction of the adrenal cortex is the most common cause of primary adrenocortical insufficiency in industrialized nations

Cushing’s Electrolytes

Patients with Cushing’s syndrome are most likely to have hypokalemia and hypernatremia.

Hypothyroidism Cause

Hypothyroidism is most commonly caused by iodine deficiency worldwide, but in developed countries, it is most commonly due to atrophy of the thyroid gland.

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Cushing's Fat Distribution

In Cushing’s syndrome, protein catabolism leads to muscle wasting in the extremities while fat accumulates centrally.

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Aldosterone Function

Aldosterone is responsible for sodium and water retention in the body.

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Hyperthyroidism Signs

Key characteristics of hyperthyroidism include exophthalmos and tachycardia.

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Addison’s Electrolytes

Electrolyte imbalance commonly seen in Addison’s disease is hyponatremia and hyperkalemia.

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Cushing’s Risk Factor

A major risk factor for developing Cushing’s syndrome is long-term corticosteroid therapy.

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Cushing’s Goal

The primary goal of treatment for Cushing’s syndrome is normalizing hormone secretion by addressing the underlying cause.

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Hypothyroidism Risk

A potential complication of hypothyroidism if left untreated is myxedema coma.

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Addison’s Diagnosis

ACTH stimulation test is used to confirm the diagnosis of Addison’s disease.

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Addisonian Crisis

Crucial intervention for a patient experiencing an Addisonian crisis is providing corticosteroid replacement therapy.

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Cushing’s Features

A common clinical feature of Cushing’s syndrome is moon face and truncal obesity.

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Hyperthyroidism Diet

Appropriate dietary recommendation for a patient with hyperthyroidism is high-calorie, high-protein diet.

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Study Notes

  • The radioactive iodine uptake (RAIU) test differentiates between the causes of hyperthyroidism.
  • Autoimmune destruction of the adrenal cortex is the most common cause of primary adrenocortical insufficiency (Addison’s disease) in industrialized nations.
  • A patient with Cushing’s syndrome is most likely to have hypokalemia and hypernatremia.
  • Hypothyroidism is most commonly caused by iodine deficiency worldwide, but in developed countries, it is most commonly due to atrophy of the thyroid gland.
  • Patients with Cushing’s syndrome often present with truncal obesity but have thin extremities due to protein catabolism leading to muscle wasting in the extremities while fat accumulates centrally.
  • Aldosterone is primarily responsible for sodium and water retention in the body.
  • A key characteristic of hyperthyroidism is exophthalmos and tachycardia.
  • An electrolyte imbalance commonly seen in Addison’s disease is hyponatremia and hyperkalemia.
  • A major risk factor for developing Cushing’s syndrome is long-term corticosteroid therapy.
  • The primary goal of treatment for Cushing’s syndrome is normalizing hormone secretion by addressing the underlying cause.
  • A potential complication of untreated hypothyroidism is myxedema coma.
  • The ACTH stimulation test is used to confirm the diagnosis of Addison’s disease.
  • Providing corticosteroid replacement therapy is crucial for a patient experiencing an Addisonian crisis.
  • A common clinical feature of Cushing’s syndrome is moon face and truncal obesity.
  • A dietary recommendation appropriate for a patient with hyperthyroidism is a high-calorie, high-protein diet.
  • Radioactive iodine therapy for hyperthyroidism works by destroying thyroid tissue to reduce hormone secretion.
  • The primary treatment for a patient with myxedema coma is IV levothyroxine and supportive care.
  • A symptom expected in a patient with untreated hypothyroidism is fatigue and weight gain.
  • Graves’ disease is caused by an autoimmune process leading to excessive thyroid hormone production.
  • Administering thyroid hormone replacement therapy is most important for a patient with hypothyroidism.
  • Increased secretion of parathyroid hormone is responsible for hyperparathyroidism.
  • Pituitary gland dysfunction is the most common cause of secondary hypothyroidism.
  • Hyperpigmentation is a distinguishing feature of Addison’s disease that is not typically seen in secondary adrenal insufficiency.
  • A common treatment for a patient with hypoparathyroidism is calcium and vitamin D supplementation.
  • A symptom that suggests a patient with hyperthyroidism is experiencing thyrotoxic crisis (thyroid storm) is severe tachycardia and hyperthermia.

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