Endocrine System Disorders: SIADH

The frequent causes of SIADH are the secretion of ectopic ADH by malignant neoplasms (particularly small-cell carcinoma of the lung), drugs that increase ADH secretion, and a variety of central nervous system disorders, including infections and trauma.

The clinical manifestations of SIADH are dominated by hyponatremia, cerebral edema, and resultant neurologic dysfunction.

The most commonly implicated tumors are gliomas (sometimes arising in the chiasm; Chapter 28) and craniopharyngiomas.

<p>A bimodal age distribution is observed, with one peak in childhood (5 to 15 years) and a second peak in adults 65 years or older.</p> Signup and view all the answers

<p>Patients usually come to attention because of headaches and visual disturbances, while children sometimes present with growth retardation due to pituitary hypofunction and GH deficiency.</p> Signup and view all the answers