Podcast
Questions and Answers
What is the primary role of the inner cell mass during development?
What is the primary role of the inner cell mass during development?
- To form the future embryo (correct)
- To organize the notochord
- To create the oral membrane
- To contribute to the placenta
What is the significance of the primitive node in embryonic development?
What is the significance of the primitive node in embryonic development?
- It acts as an organizing center for axial structure formation (correct)
- It assists in the development of the morula
- It contributes to the formation of the trophoblast
- It helps form the oropharyngeal membrane
Which structure will the oropharyngeal membrane develop into?
Which structure will the oropharyngeal membrane develop into?
- The future mouth opening (correct)
- The primitive streak
- The inner cell mass
- The trophoblast layer
What occurs during the process of compaction in the morula stage?
What occurs during the process of compaction in the morula stage?
In which stage is the structure known as the morula formed?
In which stage is the structure known as the morula formed?
What is a characteristic of the outer cell mass in the developing embryo?
What is a characteristic of the outer cell mass in the developing embryo?
What defines the region at the cranial end of the embryonic disc?
What defines the region at the cranial end of the embryonic disc?
What happens to the blastomeres during the morula stage?
What happens to the blastomeres during the morula stage?
What are blastomeres characterized by during mitotic divisions?
What are blastomeres characterized by during mitotic divisions?
What type of structures will the mesoblast formation contribute to?
What type of structures will the mesoblast formation contribute to?
What is the significance of the area located at the caudal end of the embryonic disc?
What is the significance of the area located at the caudal end of the embryonic disc?
What defines the totipotent nature of blastomeres?
What defines the totipotent nature of blastomeres?
Which of the following statements about mesoblast formation is correct?
Which of the following statements about mesoblast formation is correct?
Which process occurs first in the development of the mesodermal structures?
Which process occurs first in the development of the mesodermal structures?
Which best describes the molecular characteristics of the embryonic cells involved in mesoblast formation?
Which best describes the molecular characteristics of the embryonic cells involved in mesoblast formation?
What distinguishes the cells at the caudal end of the embryonic disc?
What distinguishes the cells at the caudal end of the embryonic disc?
Why is the concept of totipotency important in early embryonic development?
Why is the concept of totipotency important in early embryonic development?
What effect occurs to the size of cells during the cleavage stage of embryonic development?
What effect occurs to the size of cells during the cleavage stage of embryonic development?
Which structure is a derivative of the para-axial mesoderm?
Which structure is a derivative of the para-axial mesoderm?
What do lacunar spaces precede in the embryonic development?
What do lacunar spaces precede in the embryonic development?
Which of the following best describes what the hypoblast differentiates into?
Which of the following best describes what the hypoblast differentiates into?
The amnion and amniotic cavity are formed during which part of embryonic development?
The amnion and amniotic cavity are formed during which part of embryonic development?
Which structure is associated with the formation of early kidney structures?
Which structure is associated with the formation of early kidney structures?
What do the lacunar spaces eventually contribute to in the embryo?
What do the lacunar spaces eventually contribute to in the embryo?
The intraembryonic coelom is primarily responsible for the formation of which cavities?
The intraembryonic coelom is primarily responsible for the formation of which cavities?
Which of the following structures forms from the ectoderm?
Which of the following structures forms from the ectoderm?
What is considered the primary component during the development of the bilaminar embryonic disc?
What is considered the primary component during the development of the bilaminar embryonic disc?
The secondary yolk sac is developed by the end of which week?
The secondary yolk sac is developed by the end of which week?
What is the primary function of the syncytiotrophoblast during early development?
What is the primary function of the syncytiotrophoblast during early development?
Which layer is responsible for forming the gastrointestinal system?
Which layer is responsible for forming the gastrointestinal system?
From which structure does the neural plate arise?
From which structure does the neural plate arise?
What is formed as the neural plate invaginates?
What is formed as the neural plate invaginates?
Which of the following accurately describes the role of trophoblast cells?
Which of the following accurately describes the role of trophoblast cells?
What does the ectoderm differentiate into during early embryonic development?
What does the ectoderm differentiate into during early embryonic development?
Which structure is specifically created to secure anchorage in the uterus?
Which structure is specifically created to secure anchorage in the uterus?
What is the outcome of the formation of the amniotic cavity?
What is the outcome of the formation of the amniotic cavity?
What triggers the differentiation of the trophoblast into syncytiotrophoblast?
What triggers the differentiation of the trophoblast into syncytiotrophoblast?
Which layer is directly involved in erosion of the uterine wall?
Which layer is directly involved in erosion of the uterine wall?
What is the primary role of the primitive streak during gastrulation?
What is the primary role of the primitive streak during gastrulation?
Which germ layer is formed through the migration of epiblast cells during gastrulation?
Which germ layer is formed through the migration of epiblast cells during gastrulation?
What process occurs as the zygote travels through the fallopian tube toward the uterus?
What process occurs as the zygote travels through the fallopian tube toward the uterus?
What structure forms as a result of the thickening of the ectoderm during embryonic development?
What structure forms as a result of the thickening of the ectoderm during embryonic development?
Which two structures are involved in the formation of the intraembryonic mesoderm?
Which two structures are involved in the formation of the intraembryonic mesoderm?
What is the consequence of epiblast cells migrating through the primitive line?
What is the consequence of epiblast cells migrating through the primitive line?
During which phase does the neural groove begin to form?
During which phase does the neural groove begin to form?
What prevents premature implantation of the zygote?
What prevents premature implantation of the zygote?
What occurs approximately 24 hours post-fertilization?
What occurs approximately 24 hours post-fertilization?
Mesoblast cells differentiate into which of the following structures?
Mesoblast cells differentiate into which of the following structures?
What is the name of the process that involves merging of male and female pronuclei?
What is the name of the process that involves merging of male and female pronuclei?
What significance does the primitive line have in embryonic development?
What significance does the primitive line have in embryonic development?
Which structure provides the lining for the gastrointestinal and respiratory systems during embryonic development?
Which structure provides the lining for the gastrointestinal and respiratory systems during embryonic development?
What role does the hypoblast play during the formation of the definitive endoderm?
What role does the hypoblast play during the formation of the definitive endoderm?
What key purpose does the primary yolk sac serve during early development?
What key purpose does the primary yolk sac serve during early development?
Which type of mesoderm is responsible for the formation of the heart and blood vessels?
Which type of mesoderm is responsible for the formation of the heart and blood vessels?
What is the result of the split in extraembryonic mesoderm?
What is the result of the split in extraembryonic mesoderm?
During neural tube formation, which direction does the closure begin?
During neural tube formation, which direction does the closure begin?
What forms the exocoelomic membrane?
What forms the exocoelomic membrane?
What do the para-axial mesoderm cells give rise to?
What do the para-axial mesoderm cells give rise to?
Which cells are involved in the formation of peripheral nerves and parts of the craniofacial skeleton?
Which cells are involved in the formation of peripheral nerves and parts of the craniofacial skeleton?
What does the secondary yolk sac replace during development?
What does the secondary yolk sac replace during development?
Which mesodermal type is responsible for forming the urogenital system?
Which mesodermal type is responsible for forming the urogenital system?
What fills the lacunae formed by the syncytiotrophoblast?
What fills the lacunae formed by the syncytiotrophoblast?
What is the main role of the neural tube in development?
What is the main role of the neural tube in development?
Which structure acts as a protective layer during early embryonic development?
Which structure acts as a protective layer during early embryonic development?
The term 'Week of Twos' refers to which developmental stage?
The term 'Week of Twos' refers to which developmental stage?
What initiates the differentiation of mesoderm into three regions?
What initiates the differentiation of mesoderm into three regions?
Flashcards
Morula
Morula
The initial stage of embryonic development characterized by a solid ball of cells.
Primitive Node
Primitive Node
A small, elevated region at the cranial end of the primitive streak that serves as an organizing center for notochord and axial structure formation.
Trophoblast
Trophoblast
The outer layer of cells in the morula that contributes to the placenta.
Inner Cell Mass (Embryoblast)
Inner Cell Mass (Embryoblast)
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Compaction
Compaction
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Oropharyngeal Membrane
Oropharyngeal Membrane
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16-cell stage
16-cell stage
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Notochord
Notochord
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Cleavage
Cleavage
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Mesoblast Formation
Mesoblast Formation
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Totipotent
Totipotent
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Cloacal Membrane
Cloacal Membrane
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Blastocyst
Blastocyst
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Inner Cell Mass
Inner Cell Mass
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Embryonic Development
Embryonic Development
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Amnion
Amnion
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Gastrulation
Gastrulation
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Primitive Streak
Primitive Streak
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Cell Migration
Cell Migration
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Definitive Endoderm
Definitive Endoderm
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Intraembryonic Mesoderm
Intraembryonic Mesoderm
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Ectoderm
Ectoderm
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Primitive Line
Primitive Line
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Syngamy
Syngamy
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Zona Pellucida
Zona Pellucida
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Zygote
Zygote
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Neural Plate
Neural Plate
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Neural Groove
Neural Groove
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Definitive Endoderm Formation
Definitive Endoderm Formation
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Syncytiotrophoblast Formation
Syncytiotrophoblast Formation
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Human Chorionic Gonadotropin (hCG)
Human Chorionic Gonadotropin (hCG)
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Trophoblast Invasion
Trophoblast Invasion
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Neural Tube Formation
Neural Tube Formation
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Amniotic Cavity Formation
Amniotic Cavity Formation
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Lacunar Spaces
Lacunar Spaces
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Mesoderm
Mesoderm
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Hypoblast
Hypoblast
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Blastocoel
Blastocoel
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Nidation
Nidation
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Primary Yolk Sac
Primary Yolk Sac
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Neural Crest Cells
Neural Crest Cells
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Para-Axial Mesoderm
Para-Axial Mesoderm
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Intermediate Mesoderm
Intermediate Mesoderm
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Lateral Mesoderm
Lateral Mesoderm
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Somatic Mesoderm
Somatic Mesoderm
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Splanchnic Mesoderm
Splanchnic Mesoderm
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Chorionic Cavity
Chorionic Cavity
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Secondary Yolk Sac
Secondary Yolk Sac
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Lacunae
Lacunae
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Study Notes
Third Week of Development
- Gastrulation converts the bilaminar embryonic disc into a trilaminar disc.
- The primitive streak appears, establishing the embryo's axis and symmetry.
- Epiblast cells migrate, forming definitive endoderm (gastrointestinal and respiratory lining) and intraembryonic mesoderm (muscles, bones, blood).
- Ectoderm thickens into the neural plate, precursor to the central nervous system.
- The neural plate folds to form the neural groove.
Primitive Streak
- The primitive line is the initial phase of the primitive streak.
- Migratory epiblast cells through the primitive line form the definitive endoderm.
- Cells migrating between ectoderm and endoderm create the mesoblast for connective tissues, cardiovascular structures.
- The cloacal membrane, without mesoderm, will form the future anal membrane.
- The primitive node (Hensen's node) is at the cranial end, organizing notochord and axial formation.
- The oropharyngeal membrane, without mesoderm, will develop into the mouth opening.
Primitive Node and Oropharyngeal Membrane
- Mesodermal cells from the primitive streak form the cardiogenic zone.
- The heart primordium develops in the cardiogenic zone.
- The primitive node extends the chordal process cranially.
- The chordal process develops into the notochord, vital for neural tube and surrounding tissue differentiation.
- The chordal canal forms within the chordal process and facilitates amniotic/yolk sac communication.
- The neurenteric duct is a temporary connection between these cavities.
Dorsal Chord and Trilaminar Disc Formation
- The dorsal chord is a rod-like structure along the midline.
- This structure acts as a signaling center to guide neural tube and somite development.
- The embryo transforms into a trilaminar disc with ectoderm, mesoderm, and endoderm.
Neural Plate and Neuroectoderm
- The neural plate originates from thickened ectoderm cranial to the primitive node.
- Neural plate cells become neuroectoderm, forming the brain, spinal cord, and peripheral nervous system.
- The neural groove forms as the neural plate invaginates.
Neural Groove and Neural Crests
- Neural crest cells, at the neural plate edges, migrate to form peripheral nerves, melanocytes, and craniofacial structures.
Neural Tube Formation
- Neural plate edges elevate and fuse, forming the neural tube.
- Closure starts mid-embryo and progresses cranially and caudally.
Para-Axial Mesoderm
- Forms somites, which develop into vertebrae, skeletal muscles, and dermis.
First Week of Development
- Zygote formation from fertilization (single diploid cell).
- Cleavage begins with mitotic divisions.
- Blastomeres are totipotent (potential for complete embryo development).
- Morula forms at day 3 (16-cell stage).
- Blastocyst formation (day 4-5) occurs with a central blastocoel and inner/outer cell masses (embryoblast/trophoblast).
Second Week of Development
- Implantation begins during days 6-7 and completes by day 12.
- Trophoblast differentiates into cytotrophoblast (cellular layer) and syncytiotrophoblast (multinucleate layer invading the uterine wall).
- Syncytiotrophoblast secretes hCG and establishes maternal blood supply.
- Lacunae (spaces filled with maternal blood) form in the syncytiotrophoblast, preluding the uteroplacental circulation.
- Amniotic cavity appears within the epiblast.
- Amnion forms around the embryo.
- Hypoblast forms the exocoelomic membrane, lining the blastocoel.
- The blastocoel transforms into the primary yolk sac.
- Extraembryonic mesoderm forms, splitting into somatic and splanchnic layers.
- Chorionic cavity (extraembryonic coelom) separates the embryo from the trophoblast.
- Primary yolk sac transforms into the secondary yolk sac.
- A bilaminar embryonic disc, comprised of epiblast and hypoblast, forms.
Mesoderm Differentiation
- Differentiates into intermediate, lateral, and para-axial mesoderm.
- Intermediate mesoderm forms the urogenital system (kidneys, gonads).
- Lateral mesoderm forms heart, blood vessels, and body cavities.
- Para-axial mesoderm forms somites, crucial for skeletal muscle and vertebrae.
- Nephrogenic cord forms part of the intermediate mesoderm, leading to early kidney development.
- Intraembryonic coelom develops into pericardial, pleural, and peritoneal cavities.
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