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Questions and Answers
What is the immediate precursor to the blastocyst that travels through the fallopian tube?
What is the immediate precursor to the blastocyst that travels through the fallopian tube?
From which embryonic layer do the primordial germ cells originate?
From which embryonic layer do the primordial germ cells originate?
Where do primordial germ cells migrate to after leaving the yolk sac?
Where do primordial germ cells migrate to after leaving the yolk sac?
What is the ploidy of the primordial germ cells once they reach the genital ridge?
What is the ploidy of the primordial germ cells once they reach the genital ridge?
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What is the term for the cells that differentiate into mature oocytes?
What is the term for the cells that differentiate into mature oocytes?
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When do the primary oocytes start prophase of meiosis I?
When do the primary oocytes start prophase of meiosis I?
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What arrests the primary oocytes in prophase-1?
What arrests the primary oocytes in prophase-1?
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What is the approximate number of primary oocytes present at birth?
What is the approximate number of primary oocytes present at birth?
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Around which day does the cranial neuropore typically close during development?
Around which day does the cranial neuropore typically close during development?
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What is the term for the developmental defect that occurs when the neural tube fails to close in the cranial region?
What is the term for the developmental defect that occurs when the neural tube fails to close in the cranial region?
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What is the most common location for spina bifida to occur?
What is the most common location for spina bifida to occur?
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What is the maternal component of the placenta called?
What is the maternal component of the placenta called?
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Which of the following is NOT considered a type of decidua?
Which of the following is NOT considered a type of decidua?
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What is the fetal portion of the placenta called?
What is the fetal portion of the placenta called?
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What role does the decidua capsularis play?
What role does the decidua capsularis play?
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Which of the following best describes the decidua parietalis?
Which of the following best describes the decidua parietalis?
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What is the primary functional unit of the placenta?
What is the primary functional unit of the placenta?
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The chorion frondosum is best described as:
The chorion frondosum is best described as:
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What is the most common type of twins, accounting for approximately 90% of twin pregnancies?
What is the most common type of twins, accounting for approximately 90% of twin pregnancies?
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Which of the following is NOT true regarding dizygotic twins?
Which of the following is NOT true regarding dizygotic twins?
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Monozygotic twins result from:
Monozygotic twins result from:
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If a zygote splits at the two-cell stage, how many placentas, chorionic sacs, and amniotic sacs are typically formed?
If a zygote splits at the two-cell stage, how many placentas, chorionic sacs, and amniotic sacs are typically formed?
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What is the primary role of the oocyte maturation inhibitor (OMI) during oogenesis?
What is the primary role of the oocyte maturation inhibitor (OMI) during oogenesis?
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Approximately how many oocytes remain in the ovaries of a female by puberty?
Approximately how many oocytes remain in the ovaries of a female by puberty?
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What is the term for a twin that dies in the first trimester and becomes compressed and mummified?
What is the term for a twin that dies in the first trimester and becomes compressed and mummified?
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Which of the following best describes the antral stage of follicle development?
Which of the following best describes the antral stage of follicle development?
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A vanishing twin is most often caused by:
A vanishing twin is most often caused by:
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What event triggers the completion of meiosis II in an oocyte?
What event triggers the completion of meiosis II in an oocyte?
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What is the main role of the gonadotropin-releasing hormone (GnRH) in the ovarian cycle?
What is the main role of the gonadotropin-releasing hormone (GnRH) in the ovarian cycle?
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How many viable mature oocytes and polar bodies are produced upon the completion of oogenesis?
How many viable mature oocytes and polar bodies are produced upon the completion of oogenesis?
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During the zygote formation process, what happens after the sperm nucleus enters the oocyte?
During the zygote formation process, what happens after the sperm nucleus enters the oocyte?
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Approximately how many hours before ovulation does an oocyte arrest in metaphase II?
Approximately how many hours before ovulation does an oocyte arrest in metaphase II?
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Which of the following is NOT a potential cause of clubfoot?
Which of the following is NOT a potential cause of clubfoot?
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What is a key characteristic that differentiates eclampsia from preeclampsia?
What is a key characteristic that differentiates eclampsia from preeclampsia?
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Amniotic bands are theorized to originate from which of the following?
Amniotic bands are theorized to originate from which of the following?
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Which of these conditions is NOT directly associated with preeclampsia?
Which of these conditions is NOT directly associated with preeclampsia?
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Preeclampsia is typically observed starting around which gestational age?
Preeclampsia is typically observed starting around which gestational age?
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Twin-to-twin transfusion syndrome is most likely to occur in which type of pregnancy?
Twin-to-twin transfusion syndrome is most likely to occur in which type of pregnancy?
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The erector spinae muscles belong to which group of muscles based on developmental origin?
The erector spinae muscles belong to which group of muscles based on developmental origin?
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Which of the following best describes the muscle group that includes the rectus abdominis?
Which of the following best describes the muscle group that includes the rectus abdominis?
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What is the term for the complete absence of a limb?
What is the term for the complete absence of a limb?
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Which limb defect is characterized by abnormally short limbs, but with all segments present?
Which limb defect is characterized by abnormally short limbs, but with all segments present?
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Syndactyly is a condition involving which of the following?
Syndactyly is a condition involving which of the following?
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Polydactyly is associated with an abnormal duplication of which structure?
Polydactyly is associated with an abnormal duplication of which structure?
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Cleft hand and foot typically involve the absence of which metacarpal and phalangeal bones?
Cleft hand and foot typically involve the absence of which metacarpal and phalangeal bones?
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Flashcards
Oogenesis
Oogenesis
The process in which oogonia develop into mature oocytes. It begins before birth and involves several mitotic divisions, resulting in a large pool of oogonia.
Primordial Germ Cells (PGCs)
Primordial Germ Cells (PGCs)
Specialized cells that are destined to become germ cells. They originate in the epiblast and migrate to the yolk sac, waiting for a signal to activate.
Mitosis
Mitosis
The process of cell division that results in two identical daughter cells. It occurs in oogonia during the early stages of oogenesis.
Prophase of Meiosis I
Prophase of Meiosis I
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Follicle
Follicle
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Puberty
Puberty
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Primary Oocyte Arrest
Primary Oocyte Arrest
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Number of Primary Oocytes at Birth
Number of Primary Oocytes at Birth
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What is OMI?
What is OMI?
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What happens to most oocytes during childhood?
What happens to most oocytes during childhood?
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Describe the process of follicle maturation at puberty.
Describe the process of follicle maturation at puberty.
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What is a Graafian follicle?
What is a Graafian follicle?
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Describe the oocyte's state before ovulation.
Describe the oocyte's state before ovulation.
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When is meiosis II completed?
When is meiosis II completed?
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What is the final product of oogenesis?
What is the final product of oogenesis?
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Describe the pronuclei during fertilization.
Describe the pronuclei during fertilization.
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What is Neurulation?
What is Neurulation?
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What are Neural Tube Defects?
What are Neural Tube Defects?
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What is Anencephaly?
What is Anencephaly?
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What is Spina Bifida?
What is Spina Bifida?
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What is the Placenta?
What is the Placenta?
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What is the Decidua Basalis?
What is the Decidua Basalis?
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What is the Chorion Frondosum?
What is the Chorion Frondosum?
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What is the Decidua?
What is the Decidua?
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What is a chorionic villus in the placenta?
What is a chorionic villus in the placenta?
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What is chorion frondosum?
What is chorion frondosum?
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What is chorion laeve?
What is chorion laeve?
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What are dizygotic twins?
What are dizygotic twins?
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What are monozygotic twins?
What are monozygotic twins?
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What happens when a zygote splits during the two-cell stage?
What happens when a zygote splits during the two-cell stage?
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What happens when a zygote splits during the early blastocyst stage?
What happens when a zygote splits during the early blastocyst stage?
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What are vanishing twins?
What are vanishing twins?
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Preeclampsia
Preeclampsia
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Eclampsia
Eclampsia
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Limb Defects
Limb Defects
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Amniotic Bands
Amniotic Bands
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Arthrogryposis
Arthrogryposis
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Twin Transfusion Syndrome
Twin Transfusion Syndrome
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Developmental Origin of Muscles
Developmental Origin of Muscles
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Amelia
Amelia
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Meromelia
Meromelia
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Micromelia
Micromelia
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Brachydactyly
Brachydactyly
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Syndactyly
Syndactyly
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Polydactyly
Polydactyly
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Cleft Hand/Foot
Cleft Hand/Foot
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Study Notes
Review Block-1 Lectures
- Fall Semester 2024, taught by Dr. Ismail Memon, MBBS, PhD at Saba University School of Medicine.
Important Syndromes Due to Numerical Chromosomal Abnormalities
- Trisomy of Autosomes:
- Trisomy 21 (Down syndrome)
- Trisomy 18 (Edwards syndrome)
- Trisomy 13 (Patau syndrome)
- Trisomy of Sex Chromosomes:
- Klinefelter syndrome (47, XXY)
- Triple X syndrome (47, XXX)
- Monosomy:
- Turner syndrome (45, XO)
Klinefelter Syndrome
- A genetic condition affecting males.
- Results from an extra X chromosome.
- Usually diagnosed in adulthood.
- Characterized by:
- Sterility
- Testicular atrophy
- Hyalinization of seminiferous tubules
- Longer limbs
- Gynecomastia
Triple X Syndrome
- Affects approximately 1 in 1,000 females.
- Caused by an extra X chromosome.
- Often asymptomatic or has mild symptoms.
- Associated with:
- Infantile features
- Scanty menses
- Some degree of mental retardation
Turner Syndrome
- A monosomy condition affecting females.
- Results from a missing X chromosome.
- The only monosomy compatible with life.
- High spontaneous abortion rate (98%).
- Characterized by:
- Female phenotype
- Absence of ovaries
- Short stature
- Other associated abnormalities (webbed neck, lymphedema)
Cri-du-chat Syndrome
- Caused by a partial deletion of the short arm of chromosome 5.
- Affected children exhibit:
- A cat-like cry
- Microcephaly
- Mental retardation
- Congenital heart disease
Microdeletion Syndrome
- Angelman Syndrome (maternal chromosome 15):
- Mental retardation
- Inability to speak
- Poor motor development
- Unprovoked laughter
- Prader-Willi Syndrome (paternal chromosome 15):
- Hypotonia
- Obesity
- Mental retardation
Fragile X Syndrome
- Caused by a mutation in the FMR1 gene (fragile X mental retardation 1).
- Characterized by:
- Mental retardation
- Large ears
- Prominent jaw
- Pale blue irises
Primordial Germ Cells (PGCs)
- Precursors of sperm and eggs.
- Generate new generations through germ cells.
- Migrate and differentiate to form male and female gametes.
Gametogenesis
- Process of gamete development.
- Sperm fertilizes ovum to form zygote in fallopian tube.
- Zygote develops into blastocyst.
- Blastocyst implants in endometrium.
- Upper layer is called epiblast, lower layer is called hypoblast.
Oogenesis
- Process of ovum production.
- Oocytes begin maturing before birth.
- PGCs differentiate into oogonia.
- After reaching the gonad, oogonia undergo mitotic divisions.
- Majority of oogonia in prophase of meiosis I until puberty.
- Most oogonia degenerate but some survive.
- Primary oocytes remain arrested until puberty.
Ovulation
- Monthly cycles at puberty.
- Controlled by GnRH from the hypothalamus.
- Secretion of FSH and LH stimulates ovarian cycle.
- Several primary follicles stimulated to grow under influence of FSH.
Zygote Formation
- Definitive oocyte contains female pronucleus with 23 chromosomes.
- Sperm tail detaches, its nucleus enters oocyte as male pronucleus.
- Both pronuclei unite, restoring diploid number.
Cleavage and Blastocyst Formation
- Zygote divides to form two cells, then morula (16 cells).
- Morula differentiates into outer and inner cell masses.
- Blastocyst forms a cavity within the morula.
- Blastocyst enters the uterine cavity.
- Blastocyst digests zona pellucida (hatching).
Blastocyst Formation
- Embryonic pole—side of blastocyst to which inner cell mass is attached.
- Opposite side—abembryonic pole.
At the End of the 1st Week
- Embryo has inner cell mass (embryoblast) and outer cell mass (trophoblast).
- Embryoblast forms embryo proper.
- Trophoblast contributes to placenta formation.
Further Development of Embryoblast
- Epiblast cells adjacent to cytotrophoblast become amnioblasts.
- Hypoblast forms exocoelomic membrane.
- Blastocyst cavity becomes exocoelomic cavity or primary yolk sac.
- Epiblast and hypoblast form bilaminar disc.
Week 2 Summary
- Key structures and processes of week 2 development.
- Important concepts like deep implantation, hCG synthesis, formation of chorionic villi, and the development of the embryo proper.
Human Chorionic Gonadotropin (hCG)
- Glycoprotein produced by syncytiotrophoblast.
- Stimulates progesterone production by corpus luteum.
- Basis for pregnancy testing.
- Low hCG level can indicate potential spontaneous abortion or ectopic pregnancy.
- High hCG level can indicate multiple pregnancy, hydatidiform mole, or gestational trophoblastic neoplasia.
Gestational Trophoblastic Disease
- Hydatidiform mole—benign, enlarged chorionic villi, grape-like vesicles.
- Choriocarcinoma—malignant tumor of trophoblast, often following pregnancy.
Oncofetal Antigens
- Cell surface proteins present during fetal development.
- Can re-express in malignant cells.
- Used as tumor markers for diagnosis and prognosis (e.g., alpha-fetoprotein, carcinoembryonic antigen).
Gastrulation, Formation of the Trilaminar Embryonic Disc
- Conversion of bilaminar disc to a trilaminar embryonic disc (ectoderm, mesoderm, and endoderm).
- Formation of primitive streak initiates gastrulation.
- Epiblast cells differentiate into endoderm and mesoderm.
Formation of Primitive Streak
- Thickened epiblast band migrating inwards.
- FGF8 controls cell migration, invagination, and specification.
- Primitive node forms at the cranial end of the streak.
- Primitive streak becomes primitive groove and pit, signaling the start of gastrulation.
Functions of the Primitive Streak
- Determines the site of gastrulation.
- Initiates the formation of germ layers.
- Defines major body axes.
- Primitive streak fades away by the 4th week.
Tumors Associated with Gastrulation
- Sacrococcygeal teratomas: arise from remnants of the primitive streak, containing tissues from all three germ layers.
Teratogenesis Associated with Gastrulation
- Third week is a highly sensitive period for teratogenic insults.
- Teratogens can damage developing organ systems.
- Examples include alcohol (affecting forebrain and eyes) and leading to holoprosencephaly.
Neural Tube Formation
- Neural plate develops into neural tube.
- Neural folds approach, fuse, and form neural tube.
- Closure occurs in the cervical region, then cranially and caudally.
- Cranial and caudal neuropores close at specific times.
Neural Tube Defects
- Defects may occur if closure of neural tube fails.
- Anencephaly—failure to close in the cranial region.
- Spina bifida—closure failure in the cervical region or below.
Placenta
- Temporary organ during pregnancy.
- Attaches to uterine wall, provides nutrients and oxygen to baby.
- Two parts: maternal part (decidua basalis) and fetal part (chorion frondosum).
Maternal Part of Placenta - Decidua
- Uterine endometrium after implantation.
- Three types—decidua basalis, capsularis, and parietalis.
Fetal Part of Placenta - Chorion Frondosum
- Functional unit is chorionic villi.
- Villi grow from trophoblast surface.
- Villi in contact with decidua basalis develop into chorion frondosum.
- Villi in contact with decidua capsularis degenerate to chorion laeve.
Twinning
- Dizygotic (fraternal):
- Fertilization of two different oocytes by different sperms.
- Most common type of twins(90%)
- Each has its own placenta, amnion, and chorion.
- Genetics different.
- Incidence increases with maternal age.
- Monozygotic (identical):
- Result from embryonic zygote splitting.
- 10% of twin cases
- Identical genetics
- Differentiation times for developing splits dictate the formation of chorion and placenta in monozygotic twins. Different times result in different placentation structures.
Vanishing Twins
- One twin dies early during pregnancy and is resorbed or mummified (fetus papyraceus).
- Twin transfusion syndrome is one of the possible contributing factors.
Twin Transfusion Syndrome
- Usually in monozygotic twins sharing a placenta.
- Abnormal vascular connections, one twin receives more blood than the other.
- One twin may receive too little blood.
Striated Skeletal Muscle
- Cells from VLL region migrate to lateral plate mesoderm to form infrahyoid(neck), abdominal, and limb muscles.
- Remaining myotome cells form back, shoulder, and intercostal muscles.
Limb Defects
- Amelia - Complete absence of one or more limbs.
- Meromelia - Partial absence of one or more limbs.
- Micromelia - Abnormally short limbs.
- Brachydactyly - Shortened digits.
- Syndactyly - Fused digits.
- Cleft hand and foot - Abnormal cleft between bones in the hand or foot.
- Arthrogryposis- Congenital joint contractures.
Limb Defects - Amniotic Bands
- Can constrict limbs or digits in the womb.
- Not precisely understood how these bands develop.
Preeclampsia
- Maternal hypertension and proteinuria during pregnancy.
- Usually during second trimester(20 week mark)
- Can result in fetal growth retardation or death; leading to maternal complications.
- Can worsen to eclampsia, characterized by seizures.
Polydactyly
- Condition where babies have extra fingers.
- Caused by duplication of zone of polarizing activity (ZPA).
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Description
Test your knowledge on the development of germ cells and the blastocyst. This quiz covers topics such as the origin of primordial germ cells, their migration, and common developmental defects. Perfect for students studying embryology and human development.